Abstract:
:Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proinsulin conversion. The incorporation of L-[4-3H]phenylalanine into islet peptides, the ratio of hormonal to total tritiated peptides and the insulin content of the islets failed to be affected by either of these methyl esters. It is proposed that transglutaminase participates in the control of motile events involved in both the transfer of proinsulin from its site of synthesis to its site of conversion, and the translocation of insulin from its site of storage to its site of release.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Alarcon C,Valverde I,Malaisse WJdoi
10.1007/BF01117071subject
Has Abstractpub_date
1985-07-01 00:00:00pages
581-7issue
7eissn
0144-8463issn
1573-4935journal_volume
5pub_type
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