Abstract:
:Heparin causes lysis of the multilamellar liposomes of all three charges, positive, neutral, and negative, and thus releases the entrapped [3H]glucose or chromate. The lytic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with the phospholipid bilayers, which suggests that the reported lytic effect of heparin on the red blood cells may be mediated through the membrane phospholipid components of these cells.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Patel HM,Parvez N,Field J,Ryman BEdoi
10.1007/BF01121569subject
Has Abstractpub_date
1983-01-01 00:00:00pages
39-46issue
1eissn
0144-8463issn
1573-4935journal_volume
3pub_type
杂志文章abstract::Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200799
更新日期:2020-06-26 00:00:00
abstract::Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have reviewed association of CTGF in the development and progression ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20191374
更新日期:2019-07-18 00:00:00
abstract::Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116377
更新日期:1982-03-01 00:00:00
abstract::Gamma- and delta-isomers of hexachlorocyclohexane caused marked decreases in the levels of radioactive phospholipids, and increases in the levels of [3H]arachidonate incorporated into free fatty acids in rat renal tubular cells. The increased radioactivity of free fatty acids arises from the decrease of [3H]arachidona...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01540453
更新日期:1995-08-01 00:00:00
abstract::We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
更新日期:1996-02-01 00:00:00
abstract::Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180731
更新日期:2018-10-22 00:00:00
abstract::Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01120205
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:The present study aimed to construct a diagnosis model for the early differentiation of acute radiation pneumonitis (ARP) and infectious pneumonitis based on multiple parameters. METHODS:The present study included data of 152 patients admitted to the Department of Radiochemotherapy, Tangshan People's Hospita...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200299
更新日期:2020-04-30 00:00:00
abstract::Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114972
更新日期:1986-11-01 00:00:00
abstract::PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1+/- mice, Sirt1 mRNA expression was not changed but Sirt1 protein ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170926
更新日期:2017-12-12 00:00:00
abstract::In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115230
更新日期:1988-08-01 00:00:00
abstract::Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181891
更新日期:2019-01-22 00:00:00
abstract::Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four s...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181696
更新日期:2018-11-28 00:00:00
abstract::The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121918
更新日期:1984-07-01 00:00:00
abstract::Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170772
更新日期:2017-12-05 00:00:00
abstract::The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180793
更新日期:2019-01-08 00:00:00
abstract::Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01140499
更新日期:1984-04-01 00:00:00
abstract::Tuberculosis (TB), a leading infectious disease caused by Mycobacterium tuberculosis strain, takes four human lives every minute globally. Paucity of knowledge on M. tuberculosis virulence and antibiotic resistance is the major challenge for tuberculosis control. We have identified 47 acetyltransferases in the M. tube...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191661
更新日期:2019-12-20 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity, which accounts for >90% of all diagnosed oral cancers. 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200079
更新日期:2020-03-27 00:00:00
abstract::Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/s10540-005-2797-5
更新日期:2004-12-01 00:00:00
abstract::Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181271
更新日期:2018-11-20 00:00:00
abstract::Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170105
更新日期:2017-05-17 00:00:00
abstract::Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181776
更新日期:2019-02-26 00:00:00
abstract::Transfer of Bomirski amelanotic melanoma cells from in vivo to in vitro growth conditions results in occurrence of rapid melanization in their cytoplasm. The melanized cells from primary cell culture initiate tumours in hamsters, which do not contain traces of melanin and resemble typical amelanotic melanoma. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121951
更新日期:1983-02-01 00:00:00
abstract::High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01182482
更新日期:1991-06-01 00:00:00
abstract::Diabetic neuropathy (DNP) is the most common complication of diabetes mellitus affecting approximately 50% of diabetes patients. Studying the effect of potential drugs with antioxidant properties and minimal toxicities on neural cells may lead to the development of new and safe pharmacotherapy. Dexmedetomidine (DEX), ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200394
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200824
更新日期:2020-06-26 00:00:00
abstract::Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI congruent to 10(-6) M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116242
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200767
更新日期:2021-01-04 00:00:00
abstract::Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20080158
更新日期:2009-10-06 00:00:00