Abstract:
:Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biological connection between p53 and miR34b/c, in the present study, we investigated the association between polymorphisms in these two molecules and Wilms tumor susceptibility through genotyping two important functional polymorphisms (miR34b/c rs4938723 T>C and TP53 rs1042522 C>G) in 183 cases and 603 controls. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from the logistic regression analysis were used to assess the correlation of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor risk. Our results indicated that the association of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor susceptibility was not statistically significant. Stratified analysis by age, gender, and clinical stage, as well as combined effect analysis were also performed, yet, no significant association was found. In conclusion, our study indicated a lack of association between the two selected polymorphisms and Wilms tumor susceptibility. Our findings need to be verified in studies with larger sample size in the future.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Wang J,Lou S,Huang X,Mo Y,Wang Z,Zhu J,Tian X,Shi J,Zhou H,He J,Ruan Jdoi
10.1042/BSR20194202subject
Has Abstractpub_date
2020-02-28 00:00:00issue
2eissn
0144-8463issn
1573-4935pii
222181journal_volume
40pub_type
杂志文章abstract::The relative proportions of immunoregulatory T-cell subpopulations defined by OKT monoclonal antibodies are disturbed in chronic lymphocytic leukaemia (CLL) patients (even early mild cases) compared with normal subjects in the same age range. The mean ratio OKT4+:OKT8+ (helper:suppressor/cytotoxic) is reversed from th...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01314213
更新日期:1982-08-01 00:00:00
abstract::Growing evidence has uncovered that SLC34A2 plays an evident role in the progression in several types of tumors. However, the biological function and underlying molecular mechanisms of SLC34A2 remain largely unknown. Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells co...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180268
更新日期:2019-05-21 00:00:00
abstract::Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20203022
更新日期:2021-01-29 00:00:00
abstract::Myocardial ischemia/reperfusion (MI/R) triggers a complicated chain of inflammatory reactions. Dexmedetomidine (Dex) has been reported to be important in myocardial disorders. We evaluated the role of Dex in MI/R injury via the silent information regulator factor 2-related enzyme 1 (SIRT1)/mammalian target of rapamyci...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20194030
更新日期:2020-05-29 00:00:00
abstract::miR-155 has multiple functions in many physiological and pathological processes. However, little is known about the expression characteristics of avian miR-155. In the present study, partial pri-miR-155 sequences were cloned from AA+ broiler, Sanhuang broiler and Hy-Line Brown layer, respectively. Stem-loop qRT-PCR wa...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193796
更新日期:2020-06-26 00:00:00
abstract::Recent experimental evidence increasingly shows that the dysregulation of cellular bioenergetics is associated with a wide array of common human diseases, including cancer, neurological diseases and diabetes. Respiration provides a vital source of cellular energy for most eukaryotic cells, particularly high energy dem...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160083
更新日期:2016-06-30 00:00:00
abstract::The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181857
更新日期:2018-12-11 00:00:00
abstract::ATP-dependent chromatin remodeling proteins use the energy released from ATP hydrolysis to reposition nucleosomes in DNA-dependent processes. These proteins are classified as SF2 helicases. SMARCAL1, a member of this protein family, is known to modulate both DNA repair and transcription by specifically recognizing DNA...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180568
更新日期:2018-06-27 00:00:00
abstract::Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181320
更新日期:2018-09-07 00:00:00
abstract::Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1026493024066
更新日期:2000-08-01 00:00:00
abstract::This paper presents a short review of our contribution to the knowledge of the structure and function of human C1r, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of C1r, a model accounting for its autolytic activation mechanism is proposed. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119894
更新日期:1985-10-01 00:00:00
abstract::Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180411
更新日期:2018-10-17 00:00:00
abstract::Cervical cancer (CC) is ranked as the fourth most common cancer that occurs in women universally, which normally causes pain in the lower belly. Plenty of studies have stated that the expression of long non-coding RNAs (lncRNAs) is linked to the cellular development of many kinds of cancers. DSCAM-AS1 has been reporte...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192061
更新日期:2020-01-31 00:00:00
abstract::The ways in which certain inorganic elements are used in essential roles within biological systems generally are described. The two roles stressed are (1) electrolytic charge movements and (2) electronic charge movement. The value of helical proteins inside and outside membranes as mechanical coupling devices is analy...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117344
更新日期:1988-12-01 00:00:00
abstract::Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2848-y
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Our aim was to investigate the effect of emodin on intestinal and lung injury induced by acute intestinal injury in rats and explore potential molecular mechanisms. METHODS:Healthy male Sprague-Dawley (SD) rats were randomly divided into five groups (n=10, each group): normal group; saline group; acute intes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201605
更新日期:2020-09-30 00:00:00
abstract::This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatil...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020182404940
更新日期:2002-04-01 00:00:00
abstract::Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in assoc...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119804
更新日期:1989-10-01 00:00:00
abstract::Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116851
更新日期:1990-02-01 00:00:00
abstract::Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192712
更新日期:2020-02-28 00:00:00
abstract::Intracellular lipid-binding proteins (iLBPs) of the fatty acid-binding protein (FABP) family of animals transport, mainly fatty acids or retinoids, are confined to the cytosol and have highly similar 3D structures. In contrast, nematodes possess fatty acid-binding proteins (nemFABPs) that are secreted into the perivit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191292
更新日期:2019-07-23 00:00:00
abstract::The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122722
更新日期:1987-01-01 00:00:00
abstract::Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer. Methods We conducted a group of overall and subgroup pooli...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20192452
更新日期:2019-12-20 00:00:00
abstract::Safflower (Carthamus tinctorius L.) serves as a reference dicot for investigation of defence mechanisms in Asteraceae due to abundant secondary metabolites and high resistance/tolerance to environmental stresses. In plants, phenylpropanoid and flavonoid pathways are considered as two central defence signalling cascade...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140026
更新日期:2014-06-25 00:00:00
abstract::Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180854
更新日期:2018-11-09 00:00:00
abstract::We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
更新日期:1996-02-01 00:00:00
abstract::Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193094
更新日期:2019-12-20 00:00:00
abstract::We aimed to determine the effect of 'Xiaozeng No. 1' (XZ-1) on cellular apoptosis changes of gastric epithelial dysplasia (GED) and to explore the underlying mechanism. Specimens taken from the pyloric area of the stomachs from rats in each group were subjected to Hematoxylin and Eosin (H&E) staining for pathological ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171529
更新日期:2018-06-12 00:00:00
abstract::CXCL8, a member of CXC chemokines, was constitutively expressed in many types of human cancers, and its overexpression has been shown to play a critical role in promoting tumorigenesis. The purpose of the present study was to determine CXCL8 expression in a commercial human liver tissue microarray, and elucidate the e...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201169
更新日期:2020-08-28 00:00:00
abstract::The first demonstration of a method to incorporate radiolabeled methyl groups from [14C]formaldehyde into membrane proteins in human erythrocytes by reductive methylation in the presence of NaCNBH3 is described. This method is based on the work of Jentoft and Dearborn [(1979) J. Biol. Chem. 254, 4359-4365], who demons...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01136722
更新日期:1982-04-01 00:00:00