Prefoldin subunits (PFDN1-6) serve as poor prognostic markers in gastric cancer.

abstract：:Rat ventral prostate incorporated (1-14C)acetate, (1-14C)palmitate and (1-14C)linoleate into different phospholipids in a time-dependent process. The rate of incorporation into total phospholipids was higher with linoleate (10.0 nmol/g) than with either palmitate (5.8 nmol/g) or acetate (4.7 nmol/g). Predominant label...

journal_title：Bioscience reports

authors： del Hoyo N,Pulido JA,Carretero MT,Pérez-Albarsanz MA

更新日期：1990-02-01 00:00:00

abstract：:Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we assessed mitochondri...

journal_title：Bioscience reports

authors： Bird MJ,Wijeyeratne XW,Komen JC,Laskowski A,Ryan MT,Thorburn DR,Frazier AE

更新日期：2014-11-21 00:00:00

abstract：:We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca(2+)-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The RO...

journal_title：Bioscience reports

authors： Vercesi AE,Kowaltowski AJ,Grijalba MT,Meinicke AR,Castilho RF

更新日期：1997-02-01 00:00:00

abstract：:Human endothelial cells from the umbilical vein and skin fibroblasts can be separated by means of centrifugation in a density gradient of Percoll. Cells show a good recovery in culture. Viability is not impaired. ...

journal_title：Bioscience reports

authors： Sbarbati R

更新日期：1985-06-01 00:00:00

abstract：:Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...

journal_title：Bioscience reports

authors： Liu G,Zhou J,Dong M

更新日期：2019-03-22 00:00:00

abstract：:The role of the topoisomerase enzyme in DNA recombination was investigated by extracting chromosomal deoxyribonucleoproteins from a variety of cultured mammalian cells and assaying for the formation of recombinant DNA structures. Although each of the crude deoxyribonucleoprotein preparations contained topoisomerase ac...

journal_title：Bioscience reports

authors： Hamelin C,Alain R,Houde D,Berthiaume L

更新日期：1982-07-01 00:00:00

abstract：:Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...

journal_title：Bioscience reports

authors： Dan H,Li T,Lei X,Huang X,Xing Y,Shen Y

更新日期：2020-05-29 00:00:00

abstract：:Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia ...

journal_title：Bioscience reports

authors： Akter S,Jahan I,Khatun MR,Khan MF,Arshad L,Jakaria M,Haque MA

更新日期：2021-01-29 00:00:00

abstract：:Glioblastomas (GBMs) are a lethal class of brain cancer, with a median survival <15 months in spite of therapeutic advances. The poor prognosis of GBM is largely attributed to acquired chemotherapy resistance, and new strategies are urgently needed to target resistant glioma cells. Here we report a role for miR-299-5p...

journal_title：Bioscience reports

authors： Peng Y,He X,Chen H,Duan H,Shao B,Yang F,Li H,Yang P,Zeng Y,Zheng J,Li Y,Hu J,Lin L,Teng L

更新日期：2018-09-12 00:00:00

abstract：:The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...

journal_title：Bioscience reports

authors： Joensuu T,Mester J

更新日期：1994-12-01 00:00:00

abstract：:We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...

journal_title：Bioscience reports

authors： Bonincontro A,Iacoangeli A,Melucci-Vigo G,Risuleo G

更新日期：1997-12-01 00:00:00

abstract：:Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new system to study PCD in plants; namely, leaf epidermal peels. The peel represents a monolayer consisting of cells of two types: phototrophi...

journal_title：Bioscience reports

authors： Samuilov VD,Lagunova EM,Kiselevsky DB,Dzyubinskaya EV,Makarova YV,Gusev MV

更新日期：2003-04-01 00:00:00

abstract：:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...

journal_title：Bioscience reports

authors： Rothwell NJ,Saville ME,Stock MJ

更新日期：1984-04-01 00:00:00

abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...

journal_title：Bioscience reports

authors： Kim J,Barsoum IB,Loh H,Paré JF,Siemens DR,Graham CH

更新日期：2020-01-31 00:00:00

abstract：:MicroRNA-326 (miR-326) was reported to be dysregulated and involved in the progression of multiple cancers. However, the clinical significance, biological role and underlying mechanism of miR-326 in the carcinogenesis of breast cancer are still unclear. In the present study, we showed that miR-326 was down-regulated i...

journal_title：Bioscience reports

authors： Du Y,Shen L,Zhang W,Ding R,Li Q,Li S,Zhang H

更新日期：2019-07-29 00:00:00

abstract：:The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

journal_title：Bioscience reports

authors： Ondarroa M,Sharma SK,Quinn PJ

更新日期：1986-09-01 00:00:00

abstract：:We aimed to determine the effect of 'Xiaozeng No. 1' (XZ-1) on cellular apoptosis changes of gastric epithelial dysplasia (GED) and to explore the underlying mechanism. Specimens taken from the pyloric area of the stomachs from rats in each group were subjected to Hematoxylin and Eosin (H&E) staining for pathological ...

journal_title：Bioscience reports

authors： Xu B,Zhang AM,Li F,Cui M,Han J,Cao Q

更新日期：2018-06-12 00:00:00

abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our s...

journal_title：Bioscience reports

authors： Ma F,Li W,Li X,Tran BH,Suguro R,Guan R,Hou C,Wang H,Zhang A,Zhu Y,Zhu Y

更新日期：2016-12-05 00:00:00

abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...

journal_title：Bioscience reports

authors： Connelly LW,Keller RK

更新日期：1984-09-01 00:00:00

abstract：:Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [35S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) increased their rate of protein synthesis, and the maxima...

journal_title：Bioscience reports

authors： Hughes V,Humphreys JM,Edwards SW

更新日期：1987-11-01 00:00:00

abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...

journal_title：Bioscience reports

authors： Xie ZY,Liu MS,Zhang C,Cai PC,Xiao ZH,Wang FF

更新日期：2018-11-09 00:00:00

abstract：:The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...

journal_title：Bioscience reports

authors： Wang Y,Wu S,Yang X,Li X,Chen R

更新日期：2019-04-16 00:00:00

abstract：:Safflower (Carthamus tinctorius L.) serves as a reference dicot for investigation of defence mechanisms in Asteraceae due to abundant secondary metabolites and high resistance/tolerance to environmental stresses. In plants, phenylpropanoid and flavonoid pathways are considered as two central defence signalling cascade...

journal_title：Bioscience reports

authors： Dehghan S,Sadeghi M,Pöppel A,Fischer R,Lakes-Harlan R,Kavousi HR,Vilcinskas A,Rahnamaeian M

更新日期：2014-06-25 00:00:00

abstract：:Although radioactive iodine (131I) treatment (RIT) is recommended as the preferred option for patients with Graves' disease (GD), the predictive factors for its clinical outcomes are still unclear. In the present study, we aim to investigate the factors influencing the success rate of RIT treatment on primary GD with ...

journal_title：Bioscience reports

authors： Xing YZ,Zhang K,Jin G

更新日期：2020-01-31 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00

abstract：:Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...

journal_title：Bioscience reports

authors： Alarcon C,Valverde I,Malaisse WJ

更新日期：1985-07-01 00:00:00

abstract：:Identified and cloned in 1996 for the first time, G protein-coupled oestrogen receptor (ER) 30 (GPR30/GPER) has been a hot spot in the field of sex hormone research till now. In the present study, we examined the effects of low-dose oestradiol (E2) combined with G15, a specific antagonist of GPR30 on ovariectomy (OVX)...

journal_title：Bioscience reports

authors： Kang WB,Cong Y,Ru JY,Ying SQ,Zhu T,Wang DS,Liu XW,Liu G,Zhao JN

更新日期：2015-07-03 00:00:00

abstract：:The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...

journal_title：Bioscience reports

authors： Nawaz MH,Ferreira JC,Nedyalkova L,Zhu H,Carrasco-López C,Kirmizialtin S,Rabeh WM

更新日期：2018-02-21 00:00:00

abstract：:Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cell...

journal_title：Bioscience reports

authors： Diao X,Yang D,Chen Y,Liu W

更新日期：2019-04-09 00:00:00

abstract：:A non-ionic detergent such as Lubrol-PX extracts in soluble form the VIP-binding structures of rat liver plasma membranes. Detergent-solubilized proteins bind specifically [125I]VIP and the complex tracer-protein is identified by the use of Sepharose 6B columns. The interaction is only possible in the absence of deter...

journal_title：Bioscience reports

authors： Guerrero JM,Calvo JR,Garrido MR,Molinero P,Osuna C,Jiménez J,Goberna R

更新日期：1986-01-01 00:00:00