Inhibition of microRNA-299-5p sensitizes glioblastoma cells to temozolomide via the MAPK/ERK signaling pathway.

abstract：:Matrix-bound monoclonal antibodies against urokinase have been used to purify this enzyme by affinity chromatography. In a single-step procedure, urokinase can be isolated from crude preparations with high yield and high purity, and without loss of enzymatic activity. ...

journal_title：Bioscience reports

authors： Hérion P,Bollen A

更新日期：1983-04-01 00:00:00

abstract：:The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...

journal_title：Bioscience reports

authors： Cohen C,Lanar DE,Parry DA

更新日期：1987-01-01 00:00:00

abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...

journal_title：Bioscience reports

authors： Wenger SL,Senft JR,Sargent LM,Bamezai R,Bairwa N,Grant SG

更新日期：2004-12-01 00:00:00

abstract：:The response to D-glucose (0-21 mM) was studied in neutrophil granulocytes from obese, hyperglycemic and hyperinsulinemic Umeå ob/ob mice and their lean, littermate controls in order to further elucidate the effects of in vivo and in vitro hyperglycemia on neutrophil function. Neutrophil random locomotion on glass and...

journal_title：Bioscience reports

authors： Oldenborg PA,Sehlin J

更新日期：1997-10-01 00:00:00

abstract：:Fatty-acid synthesis has been measured in vivo with 3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also ...

journal_title：Bioscience reports

authors： Rothwell NJ,Stock MJ,Trayhurn P

更新日期：1983-03-01 00:00:00

abstract：:Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...

journal_title：Bioscience reports

authors： Yang ML,Huang Z,Wu LN,Wu R,Ding HX,Wang BG

更新日期：2019-07-12 00:00:00

abstract：:Safflower (Carthamus tinctorius L.) serves as a reference dicot for investigation of defence mechanisms in Asteraceae due to abundant secondary metabolites and high resistance/tolerance to environmental stresses. In plants, phenylpropanoid and flavonoid pathways are considered as two central defence signalling cascade...

journal_title：Bioscience reports

authors： Dehghan S,Sadeghi M,Pöppel A,Fischer R,Lakes-Harlan R,Kavousi HR,Vilcinskas A,Rahnamaeian M

更新日期：2014-06-25 00:00:00

abstract：:Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

journal_title：Bioscience reports

authors： Zhao H,Liu M,Liu H,Suo R,Lu C

更新日期：2020-03-27 00:00:00

abstract：:Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...

journal_title：Bioscience reports

authors： Huang Y,Fan G,Yang F

更新日期：1994-08-01 00:00:00

abstract：:A range of different types of interactions at biological membrane surfaces have been studied using various different spin label electron spin resonance (ESR) techniques. These include: (1) the interfacial ionization of local anaesthetics, (2) the binding of peripheral membrane proteins, (3) the membrane insertion of t...

journal_title：Bioscience reports

authors： Marsh D

更新日期：1999-08-01 00:00:00

abstract：:Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...

journal_title：Bioscience reports

authors： Warrier VU,Makandar AI,Garg M,Sethi G,Kant R,Pal JK,Yuba E,Gupta RK

更新日期：2019-10-30 00:00:00

abstract：:The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...

journal_title：Bioscience reports

authors： Burgoyne RD

更新日期：1984-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in ca...

journal_title：Bioscience reports

authors： Ding B,Lou W,Xu L,Fan W

更新日期：2018-10-09 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...

journal_title：Bioscience reports

authors： Ma Y,Chen SS,Feng YY,Wang HL

更新日期：2020-09-30 00:00:00

abstract：:Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...

journal_title：Bioscience reports

authors： Sim E,Palmer MS,Puklavec M,Sim RB

更新日期：1983-12-01 00:00:00

abstract：:The physiological role of an alternative oxidase and an uncoupling protein in plant and protists is discussed in terms of thermogenesis and energy metabolism balance in the cell. It is concluded that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitocho...

journal_title：Bioscience reports

authors： Jarmuszkiewicz W,Sluse-Goffart CM,Vercesi AE,Sluse FE

更新日期：2001-04-01 00:00:00

abstract：:Western blotting was used as a powerful alternative to immunoprecipitation for the detection of the simian virus 40 (SV40) large tumor (T) antigen. After resolution by electrophoresis on a SDS-polyacrylamide gel of a [35S]methionine labeled crude extract from SV40 infected monkey kidney cells, the separated proteins w...

journal_title：Bioscience reports

authors： Dietrich JB

更新日期：1985-02-01 00:00:00

abstract：:Sendai virus envelopes (SVE) were isolated from Sendai virus particles by Triton X-100 solubilization and ultracentrifugation. The envelopes were reconstituted in the presence of the fluorescent dye calcein by gradual removal of the detergent with Bio-beads SM-2. The internal volume of reconstituted Sendai virus envel...

journal_title：Bioscience reports

authors： Bartzatt RL,Volsky DJ

更新日期：1984-07-01 00:00:00

abstract：:Recent experimental evidence increasingly shows that the dysregulation of cellular bioenergetics is associated with a wide array of common human diseases, including cancer, neurological diseases and diabetes. Respiration provides a vital source of cellular energy for most eukaryotic cells, particularly high energy dem...

journal_title：Bioscience reports

authors： Lal S,Alam MM,Hooda J,Shah A,Cao TM,Xuan Z,Zhang L

更新日期：2016-06-30 00:00:00

abstract：:Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the uncoupling protein yielded five positive clones, pUCPr...

journal_title：Bioscience reports

authors： Ridley RG,Patel HV,Parfett CL,Olynyk KA,Reichling S,Freeman KB

更新日期：1986-01-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...

journal_title：Bioscience reports

authors： Mao Z,Li H,Du B,Cui K,Xing Y,Zhao X,Zai S

更新日期：2017-11-06 00:00:00

abstract：:Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus--a tissue culture-adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insu...

journal_title：Bioscience reports

authors： Szopa TM,Gamble DR,Taylor KW

更新日期：1985-01-01 00:00:00

abstract：:Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters in a Chinese MHD cohort. Accordingly, we re...

journal_title：Bioscience reports

authors： Wang T,Li Y,Wu H,Chen H,Zhang Y,Zhou H,Li H

更新日期：2020-08-28 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...

journal_title：Bioscience reports

authors： Bai R,Chi S,Li X,Dai X,Ji Z,Jian M,Bi Y,Wang F,Ding Z,Luo L,Chen T,Liu A,Bao F

更新日期：2019-05-31 00:00:00

abstract：:The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...

journal_title：Bioscience reports

authors： Gomperts BD,Cockcroft S,Howell TW,Nüsse O,Tatham PE

更新日期：1987-05-01 00:00:00

abstract：:We aimed to determine the effect of 'Xiaozeng No. 1' (XZ-1) on cellular apoptosis changes of gastric epithelial dysplasia (GED) and to explore the underlying mechanism. Specimens taken from the pyloric area of the stomachs from rats in each group were subjected to Hematoxylin and Eosin (H&E) staining for pathological ...

journal_title：Bioscience reports

authors： Xu B,Zhang AM,Li F,Cui M,Han J,Cao Q

更新日期：2018-06-12 00:00:00

abstract：:In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...

journal_title：Bioscience reports

authors： Bokka CS,Veeramachaneni GK,Thunuguntla VBSC,Manda NK,Bondili JS

更新日期：2019-11-29 00:00:00

abstract：:We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...

journal_title：Bioscience reports

authors： Jia Y,Zhao LM,Bai HY,Zhang C,Dai SL,Lv HL,Shan BE

更新日期：2019-01-08 00:00:00

abstract：:Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...

journal_title：Bioscience reports

authors： Du Y,Sun D,Li Y

更新日期：2020-12-23 00:00:00

abstract：:Peptide sequencing of the complement system regulatory protein, factor H, permitted the synthesis of a mixed sequence oligonucleotide probe. Human liver cDNA libraries were screened and factor H-specific clones selected. No full-length clone was obtained, but the largest available clone, R2a, was found to encode the C...

journal_title：Bioscience reports

authors： Day AJ,Ripoche J,Lyons A,McIntosh B,Harris TJ,Sim RB

更新日期：1987-03-01 00:00:00