Abstract:
:Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC. In this review, we first overviewed up-to-date findings regarding miRNA and lncRNA in drug resistance of HCC, then summarized specific mechanisms that they modulate chemoresistance of HCC, and finally discussed their potential clinical application in overcoming the obstacle of HCC chemoresistance in the future.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Ding B,Lou W,Xu L,Fan Wdoi
10.1042/BSR20180915subject
Has Abstractpub_date
2018-10-09 00:00:00issue
5eissn
0144-8463issn
1573-4935pii
BSR20180915journal_volume
38pub_type
杂志文章,评审abstract::Amphiphilic anionic peptides have been used to enhance the efficiency of transfection by helping plasmids to escape from endosomes to the cytosol. It has been shown that efficiency of an eicosamers containing five glutamyl residues (E5), can be considerably enhanced either by transforming it into a dimer or by adding ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1010382001654
更新日期:2000-10-01 00:00:00
abstract::Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116998
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abstract::The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170186
更新日期:2017-06-27 00:00:00
abstract::The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190091
更新日期:2019-04-16 00:00:00
abstract::Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA), play a unique role in modulating the apoptotic threshold in cells. The mechanism is thought to involve, in part, inhibition of translocation for Bax from the cytosol to mitochondria. Here, we attempted to use the native fluoresce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/s10540-006-9019-7
更新日期:2006-06-01 00:00:00
abstract::Phagocytosis by neutrophils, macrophages, and other professional phagocytes requires rapid remodeling of actin. Early phagosomes are surrounded by a rim of F-actin that is disassembled during phagosomoal maturation. Breakdown of periphagosomal F-actin and phagolysosome fusion are calcium dependent processes in neutrop...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1022025903688
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20191519
更新日期:2019-11-29 00:00:00
abstract::The nature of certain forms of memory is discussed in relation to neural networks and REM sleep. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117331
更新日期:1988-12-01 00:00:00
abstract::Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200784
更新日期:2020-09-30 00:00:00
abstract::Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20080032
更新日期:2008-12-01 00:00:00
abstract::An antibody was raised to the synthetic pentapeptide pGluHisProGlyLys which, in radioimmunoassay (RIA), could detect the pentapeptide at a level of 10 fmole per tube and exhibited less than 0.5 per cent cross reactivity with a series of related peptides. The RIA was used to demonstrate the presence of C-terminally ext...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114948
更新日期:1986-06-01 00:00:00
abstract::In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01128818
更新日期:1984-09-01 00:00:00
abstract::The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01788360
更新日期:1995-10-01 00:00:00
abstract::Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20193220
更新日期:2019-10-30 00:00:00
abstract::HIV-1 infects host cells by sequential interactions of its fusion protein (gp120-gp41) with receptors CD4, CXCR4 and/or CCR5 followed by fusion of viral and host membranes. Studies indicate that additional factors such as receptor density and composition of viral and cellular lipids can dramatically modulate the fusio...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2894-5
更新日期:2005-10-01 00:00:00
abstract::To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PB...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201573
更新日期:2020-11-27 00:00:00
abstract::Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA. When p53 falls, other members of its family may become targets to attack tumoural cells. p73 has shown c...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150039
更新日期:2015-04-28 00:00:00
abstract::A range of different types of interactions at biological membrane surfaces have been studied using various different spin label electron spin resonance (ESR) techniques. These include: (1) the interfacial ionization of local anaesthetics, (2) the binding of peripheral membrane proteins, (3) the membrane insertion of t...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020590122846
更新日期:1999-08-01 00:00:00
abstract::eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2-3 phosphates per eNOS monomer. Phosphorylation decreases NO synthesis...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140015
更新日期:2014-09-17 00:00:00
abstract::The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM)....
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117437
更新日期:1985-01-01 00:00:00
abstract::Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed (EECLS) in Wistar rats to measure its safety profile. The single do...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202345
更新日期:2021-01-29 00:00:00
abstract::In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids. Mutants unable to form HMP can be rescued by exogenous HMP, implying the presence of HMP transporters in the plasma membrane and plastids. Analysis of bacterial genomes reve...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180048
更新日期:2018-03-29 00:00:00
abstract::Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180005
更新日期:2018-07-02 00:00:00
abstract::Tuberculosis (TB) is a chronic infectious disease that has been threatening public health for many years. Several studies have shown the relationship between the macrophage migration inhibitory factor (MIF)-794 CATT (MIF-794 CATT) microsatellite polymorphism and susceptibility to TB. However, the results remain inconc...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20171626
更新日期:2018-07-06 00:00:00
abstract::LGMD (limb-girdle muscular dystrophy) and CMD (congenital muscular dystrophy) are two common forms of neuromuscular disorders which are distinguishable by their age of onset but with probably a similar underlying pathway. In the present study, we report immunohistochemical, Western-blot and genetic analyses in a large...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20100026
更新日期:2011-04-01 00:00:00
abstract::We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1027364308147
更新日期:1997-12-01 00:00:00
abstract::Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180731
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:MicroRNA-135 (miR-135) is a well-known non-coding RNA that has been demonstrated to participate in tumorigenesis and cancer development; however, the clinical prognostic value of miR-135 in digestive system cancers remains controversial. This meta-analysis aims to explore the potential value of miR-135 as a ...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20190845
更新日期:2019-12-20 00:00:00
abstract::Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180367
更新日期:2018-05-22 00:00:00
abstract::The existence of cancer stem cells (CSCs) is considered as a direct reason for the failure of clinic treatment in hepatocellular carcinoma (HCC). Growing evidences have demonstrated that miRNAs play an important role in regulation of stem cell proliferation, differentiation and self-renewal and their aberrances cause ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150084
更新日期:2015-05-22 00:00:00