Spacer length dependence on the efficiency of dimeric anionic peptides in gene transfer by glycosylated polylysine/plasmid complexes.

abstract：:Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...

journal_title：Bioscience reports

authors： Li B,Yuan Z,Jiang J,Rao Y

更新日期：2018-12-11 00:00:00

abstract：:Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expres...

journal_title：Bioscience reports

authors： Jing Y,Yang Y,Hao F,Song Y,Zhang X,Zhang Y,Huang X,Hu Q,Ni Y

更新日期：2018-11-20 00:00:00

abstract：:Rabbit reticulocyte lysates, gel filtered on Sephadex G-25 with or without ATP (or its analogs), were preincubated at 37 degrees C and their subsequent binding to p3A4,3'-[32P]pCp was studied. Lysates filtered without ATP or in the presence of 0.1 mM 8-bromo-ATP, 1,N6-etheno-ATP, or ITP showed a time-dependent decreas...

journal_title：Bioscience reports

authors： Wu JM,Wertheimer SJ,Eslami B,Figuereido JC,Goswami BB

更新日期：1985-12-01 00:00:00

abstract：:Accumulating evidence demonstrates that long non-coding RNAs (LncRNAs) play important roles in regulating gene expression and are involved in various cancers, including colorectal cancer (CRC). However, LncRNA profiles in CRC remain largely unknown. The present study aims to find the key LncRNA associated with CRC and...

journal_title：Bioscience reports

authors： Sun L,Xue H,Jiang C,Zhou H,Gu L,Liu Y,Xu C,Xu Q

更新日期：2016-05-06 00:00:00

abstract：:Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...

journal_title：Bioscience reports

authors： Cherubin P,Guyette J,Taylor M,O'Donnell M,Herndon L,Burress H,Riad A,Tatulian SA,Teter K

更新日期：2018-09-07 00:00:00

abstract：:The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...

journal_title：Bioscience reports

authors： Sha HH,Wang Z,Dong SC,Hu TM,Liu SW,Zhang JY,Wu Y,Ma R,Wu JZ,Chen D,Feng JF

更新日期：2018-02-13 00:00:00

abstract：:Tuberculosis (TB) is a chronic infectious disease that has been threatening public health for many years. Several studies have shown the relationship between the macrophage migration inhibitory factor (MIF)-794 CATT (MIF-794 CATT) microsatellite polymorphism and susceptibility to TB. However, the results remain inconc...

journal_title：Bioscience reports

authors： Ma M,Tao L,Liu A,Liang Z,Yang J,Peng Y,Dai X,Bai R,Ji Z,Jian M,Bao F

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. MATERIALS AND METHODS:The data used in this research were collected from Google Scholar, Web of Science, CNKI, and ...

journal_title：Bioscience reports

authors： Wang BJ,Chen JY,Guan Y,Liu DC,Cao ZC,Kong J,Wu ZS,Wu WY

更新日期：2021-01-27 00:00:00

abstract：:To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PB...

journal_title：Bioscience reports

authors： Li N,Zhu L,Zhou H,Zheng D,Xu G,Sun L,Gao J,Shao G

更新日期：2020-11-27 00:00:00

abstract：:In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...

journal_title：Bioscience reports

authors： Sun H,Zhang J,Ma Y,Liu J

更新日期：2020-09-30 00:00:00

abstract：:Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...

journal_title：Bioscience reports

authors： Yang ML,Huang Z,Wu LN,Wu R,Ding HX,Wang BG

更新日期：2019-07-12 00:00:00

abstract：:Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remark...

journal_title：Bioscience reports

authors： Sun B,Ding Y,Jin X,Xu S,Zhang H

更新日期：2019-05-02 00:00:00

abstract：:Since the Protein Data Bank (PDB) was founded in 1971, there are now over 120,000 depositions, the majority of which are from X-ray crystallography and 90% of those made use of synchrotron beamlines. At the Cambridge Structure Database (CSD), founded in 1965, there are more than 800,000 'small molecule' crystal struct...

journal_title：Bioscience reports

authors： Helliwell JR

更新日期：2017-07-04 00:00:00

abstract：:In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids. Mutants unable to form HMP can be rescued by exogenous HMP, implying the presence of HMP transporters in the plasma membrane and plastids. Analysis of bacterial genomes reve...

journal_title：Bioscience reports

authors： Beaudoin GAW,Johnson TS,Hanson AD

更新日期：2018-03-29 00:00:00

abstract：:Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...

journal_title：Bioscience reports

authors： Sim E,Palmer MS,Puklavec M,Sim RB

更新日期：1983-12-01 00:00:00

abstract：:Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in assoc...

journal_title：Bioscience reports

authors： Kikuchi A,Kamo I,Fujisawa K,Nonaka I

更新日期：1989-10-01 00:00:00

abstract：:Ric c1, an allergenic protein from Ricinus communis , is an insect α-amylase inhibitor that has become an occupational allergen. Ric c1 can cross-react with allergens from wheat, soybean, peanut, shrimp, fish, gluten, house dust, tobacco, and air fungus, thereby amplifying the concern and risks caused by Ricinus aller...

journal_title：Bioscience reports

authors： Pacheco-Soares T,de Oliveira Carvalho A,da Silva Araújo J,de Souza GDS,Machado OLT

更新日期：2018-02-14 00:00:00

abstract：:Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...

journal_title：Bioscience reports

authors： Franchi J,Marteau C,Crola da Silva C,Mitterrand M,André P,Kieda C

更新日期：2008-02-01 00:00:00

abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...

journal_title：Bioscience reports

authors： Abate F,Malito E,Cozzi R,Lo Surdo P,Maione D,Bottomley MJ

更新日期：2014-11-24 00:00:00

abstract：:The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membran...

journal_title：Bioscience reports

authors： Senar S,Gutierrez-Ocaña MT,Perez-Albarsanz MA,Recio MN

更新日期：1991-04-01 00:00:00

abstract：:In a study of Necturus gallbladder epithelium Benzel et al. (Benzel et al., 1980) found that low (0.2-1.2 microM) and higher concentrations (1.5 microM and more) of cytochalasin B (CB) caused an increase and decrease in the transepithelial electrical resistance (TER), respectively. Moreover, there were slight changes ...

journal_title：Bioscience reports

authors： Nybom P,Magnusson KE

更新日期：1996-08-01 00:00:00

abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

journal_title：Bioscience reports

authors： Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

更新日期：2018-02-12 00:00:00

abstract：:Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...

journal_title：Bioscience reports

authors： Peng C,Zou X,Xia W,Gao H,Li Z,Liu N,Xu Z,Gao C,He Z,Niu W,Fang R,Biswas S,Agrez M,Zhi X,Niu J

更新日期：2018-12-07 00:00:00

abstract：:The kinetics of the fusion process between erythrocyte ghosts, as induced by Sendai virus, were readily revealed by a simple fluorescence procedure previously employed to characterize the fusion of viruses with biological membranes. The method relies on the relief of fluorescence selfquenching of the membrane-inserted...

journal_title：Bioscience reports

authors： Hoekstra D,Klappe K

更新日期：1986-11-01 00:00:00

abstract：:Cathepsin D occurs in two forms, a single polypeptide chain (Mr 44 000) and a non-covalent complex of two peptides of Mr 14 000 and 30 000 that is derived by proteolytic processing of the 44 000 polypeptide. The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid env...

journal_title：Bioscience reports

authors： Pain RH,Lah T,Turk V

更新日期：1985-10-01 00:00:00

abstract：:The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active subst...

journal_title：Bioscience reports

authors： Feizi T,Gooi HC,Loomes LM,Suzuki Y,Suzuki T,Matsumoto M

更新日期：1984-09-01 00:00:00

abstract：:The concentration of Na+ and K+ and the pH in the cytoplasm of Lettré cells was measured by monitoring the net flux of H+, Na+, or K+ across the plasma membrane which had been rendered permeable to these ions by the action of Sendai virus. Ion flux was measured directly by analysis of cell composition, or indirectly b...

journal_title：Bioscience reports

authors： Bashford CL,Alder G,Micklem KJ,Pasternak CA

更新日期：1983-07-01 00:00:00

abstract：:Blood platelets have the capacity to participate in a number of physiological as well as pathological processes within the circulation. In order to evaluate their cellular reactivity a number of platelet function tests have been developed. The main in vitro function tests are assessment of aggregation and adhesion, se...

journal_title：Bioscience reports

authors： Spangenberg P,Till U

更新日期：1989-06-01 00:00:00

abstract：:The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of...

journal_title：Bioscience reports

authors： Cai F,Zhang Y,Li J,Huang S,Gao R

更新日期：2020-03-27 00:00:00

abstract：:Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...

journal_title：Bioscience reports

authors： Liu X,Gao H,Zhang J,Xue D

更新日期：2019-05-07 00:00:00