Abstract：
:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and IL-1β. The results showed that caspase-1 and IL-1β expression levels were significantly upregulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the downregulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Ydoi
10.1042/BSR20171438subject
Has Abstractpub_date
2018-02-12 00:00:00eissn
0144-8463issn
1573-4935pii
BSR20171438pub_type
杂志文章abstract：:Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1026493024066
更新日期：2000-08-01 00:00:00
abstract：:Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expres...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181271
更新日期：2018-11-20 00:00:00
abstract：:Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190562
更新日期：2019-07-08 00:00:00
abstract：: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182023
更新日期：2019-02-27 00:00:00
abstract：:In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191835
更新日期：2019-11-29 00:00:00
abstract：:Fatty-acid synthesis has been measured in vivo with 3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01122453
更新日期：1983-03-01 00:00:00
abstract：OBJECTIVE:To observe the restraining effect of IL-38 on inflammatory response in collagen-induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α signaling pathway. METHODS:40 SD rats were randomly divided into Control group, CIA group, CLL group and CLH group, with 10 rats in each group;...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182431
更新日期：2020-05-29 00:00:00
abstract：:Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20080158
更新日期：2009-10-06 00:00:00
abstract：:The nature of certain forms of memory is discussed in relation to neural networks and REM sleep. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117331
更新日期：1988-12-01 00:00:00
abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160265
更新日期：2017-01-17 00:00:00
abstract：:Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa. In the present study, we investigated the possible role of a novel autoph...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170770
更新日期：2019-08-23 00:00:00
abstract：:Background: Many epidemiologic studies have explored the association between age at last birth (ALB) and the risk of epithelial ovarian cancer, but the results remain controversial. Methods: A literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and WanFang Med Onli...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20182035
更新日期：2019-09-13 00:00:00
abstract：:The condensing component of chicken liver fatty acid synthetase is inhibited by a sulfhydryl reagent, iodoacetamide, with a second-order rate constant of 0.23 M-1 sec-1 at pH 7.0 and 0 degrees. Complete inactivation requires the modification of approximately 8 -SH groups per dimer of the enzyme. Quantitation of the ex...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116383
更新日期：1982-03-01 00:00:00
abstract：:Common colds were shortened by 7 days in a 1984 clinical trial using zinc gluconate throat lozenges each 2 h. Between then and 2004, 10 other double-blind, placebo-controlled clinical trials showed widely varying results. This re-analysis of these trials presents solution chemistry methods to elucidate differences in ...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1023/b:bire.0000037754.71063.41
更新日期：2004-02-01 00:00:00
abstract：:Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion pr...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1010454803579
更新日期：2000-12-01 00:00:00
abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117013
更新日期：1981-02-01 00:00:00
abstract：:Superoxide dismutase (SOD), a metal containing enzyme is present in parasite Leishmania donovani as well as in host macrophages both resident and activated in a detectable amount, although the level is much higher in the latter case. It is observed that at any particular protein concentration, the SOD activity is high...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116457
更新日期：1988-04-01 00:00:00
abstract：:Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (RRBP1) has been shown to participate in various aspects of malignancies. The clinical significance of RRBP1 and its involvement in the epithelial ovarian cancer have yet to be studied. The aim of the present study was to investigate the ...
journal_title：Bioscience reports
pub_type： 临床试验,杂志文章
doi：10.1042/BSR20190656
更新日期：2019-07-23 00:00:00
abstract：:Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/s10540-005-2848-y
更新日期：2005-02-01 00:00:00
abstract：:This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...
journal_title：Bioscience reports
pub_type： 评论,信件
doi：10.1042/BSR20180505
更新日期：2018-10-31 00:00:00
abstract：:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20194431
更新日期：2020-03-27 00:00:00
abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180854
更新日期：2018-11-09 00:00:00
abstract：:Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170105
更新日期：2017-05-17 00:00:00
abstract：OBJECTIVE:Our aim was to investigate the effect of emodin on intestinal and lung injury induced by acute intestinal injury in rats and explore potential molecular mechanisms. METHODS:Healthy male Sprague-Dawley (SD) rats were randomly divided into five groups (n=10, each group): normal group; saline group; acute intes...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201605
更新日期：2020-09-30 00:00:00
abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116866
更新日期：1987-09-01 00:00:00
abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...
journal_title：Bioscience reports
pub_type： 杂志文章,收录出版
doi：10.1042/BSR20171070
更新日期：2017-11-06 00:00:00
abstract：:The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117101
更新日期：1986-09-01 00:00:00
abstract：:Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181176
更新日期：2018-10-09 00:00:00
abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182458
更新日期：2020-04-30 00:00:00
abstract：:Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20180161
更新日期：2018-07-06 00:00:00
