Abstract:
: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) < 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Shang H,Hao Y,Hu W,Hu X,Jin Qdoi
10.1042/BSR20182023subject
Has Abstractpub_date
2019-02-27 00:00:00issue
2eissn
0144-8463issn
1573-4935pii
BSR20182023journal_volume
39pub_type
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