Evidence on the conformation of HeLa-cell 5.8 S rRNA during interaction with 28 S rRNA.

Abstract:

:The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter alia those within the 5'- and 3'-terminal sequences, differs in the two forms of 5.8 S rRNA. We therefore conclude that the sequences comprising stem 'a' of the isolated 5.8 S rRNA are involved in hydrogen-bonding to 28 S rRNA in the 60 S ribosomal subunit, but that the interactions are more subtle and complex than those proposed in earlier models.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Kelly JM,Goddard JP

doi

10.1007/BF01116191

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

413-22

issue

5

eissn

0144-8463

issn

1573-4935

journal_volume

1

pub_type

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