Abstract：
:Oral vaccination requires an antigen delivery vehicle to protect the antigen and to enhance translocation of the antigen to the mucosa-associated lymphoid tissue. A variety of antigen delivery vehicles including liposomes have been studied for mucosal immunization. The advantages of liposome formulations are their particulate form and the ability to accommodate immunomodulators and targeting molecules in the same package. Many conventional liposomes are variably unstable in acids, pancreatic juice and bile. Nevertheless, carefully designed liposomes have demonstrated an impressive efficacy in inducing mucosal IgA responses, compared to free antigens and other delivery vehicles. However, liposomes as an oral vaccine vehicle are not yet optimized. To design liposomes that are stable in the harsh intestinal environment and are efficiently taken up by the M cells remains a challenge. This review summarizes recent research efforts using liposomes as an antigen carrier for oral vaccines with practical attention to liposome designs and interaction with the M cells.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Zho F,Neutra MRdoi
10.1023/a:1020103109483keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
355-69issue
2eissn
0144-8463issn
1573-4935journal_volume
22pub_type
杂志文章,评审abstract：BACKGROUND:Breast cancer (BC) is the most common malignancy among females worldwide. The tumor microenvironment usually prevents effective lymphocyte activation and infiltration, and suppresses infiltrating effector cells, leading to a failure of the host to reject the tumor. CC chemokines play a significant role in in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20202042
更新日期：2020-11-27 00:00:00
abstract：:Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20171234
更新日期：2018-04-13 00:00:00
abstract：:Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114972
更新日期：1986-11-01 00:00:00
abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181794
更新日期：2019-07-25 00:00:00
abstract：:Fungal endophytes are known to secrete a large array of secondary metabolites (phenols, flavonoids, indole acetic acid (IAA) etc.) that facilitate crops under stress conditions. Considering this, a potent plant growth promoting endophyte (SXSp1) from the spines and leaves of Solanum xanthocarpum L. has been isolated. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190290
更新日期：2019-10-30 00:00:00
abstract：:The large size of a 1.5-MDa ice-binding adhesin [MpAFP (Marinomonas primoryensis antifreeze protein)] from an Antarctic Gram-negative bacterium, M. primoryensis, is mainly due to its highly repetitive RII (Region II). MpAFP_RII contains roughly 120 tandem copies of an identical 104-residue repeat. We have previously d...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140083
更新日期：2014-07-04 00:00:00
abstract：:Trypsin-releasable glycosaminoglycans from the luminal surface of intact pig aorta were measured following metabolic labelling with [35S]sulphate. Chondroitin sulphate was found to be present at a surface density equal to that already established for heparan sulphate (5 X 10(11) chains per cm2). This result was confir...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01124788
更新日期：1987-03-01 00:00:00
abstract：:Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181722
更新日期：2019-07-15 00:00:00
abstract：:The discovery of genes that control cell division in yeast, and their relation to cancer, is reviewed. ...
journal_title：Bioscience reports
pub_type： 传,历史文章
doi：10.1023/a:1020918107706
更新日期：2002-06-01 00:00:00
abstract：:N-(2-Hydroxypropyl)methacrylamide copolymers bearing oligopeptide side-chains terminating in p-nitroaniline (NAp) were incubated with rat liver lysosomal enzymes in the presence of the thiol glutathione, and the rate of p-nitroaniline release was measured. Twelve of the 16 side-chains investigated were hydrolysed to r...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01122173
更新日期：1982-12-01 00:00:00
abstract：:Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in assoc...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01119804
更新日期：1989-10-01 00:00:00
abstract：:Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion pr...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1010454803579
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. METHODS:The robust rank aggregation method was used to mine differentially expressed genes...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203973
更新日期：2021-01-29 00:00:00
abstract：:The present study was designed to investigate the protective effect of moracin on primary culture of nucleus pulposus cells in intervertebral disc and explore the underlying mechanism. Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1β, IL-6 and TNF-α) in nucleus pulpos...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191673
更新日期：2019-12-20 00:00:00
abstract：:Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20080158
更新日期：2009-10-06 00:00:00
abstract：:ATP-dependent chromatin remodeling proteins use the energy released from ATP hydrolysis to reposition nucleosomes in DNA-dependent processes. These proteins are classified as SF2 helicases. SMARCAL1, a member of this protein family, is known to modulate both DNA repair and transcription by specifically recognizing DNA...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180568
更新日期：2018-06-27 00:00:00
abstract：:The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01122722
更新日期：1987-01-01 00:00:00
abstract：:Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170768
更新日期：2017-10-11 00:00:00
abstract：:Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190100
更新日期：2019-05-02 00:00:00
abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/s10540-005-2797-5
更新日期：2004-12-01 00:00:00
abstract：:Calmodulin (CaM)-like activity was detected in human serum and foetal calf serum, with an activity 10 times more than that detectable in plasma. Serum CaM was largely accounted for by release from human platelets as confirmed by both radioimmunoassay and sodium-dodecyl-sulphate/polyacrylamide-gel electrophoresis of Ca...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01121017
更新日期：1984-08-01 00:00:00
abstract：:Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191831
更新日期：2019-08-23 00:00:00
abstract：:Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01120205
更新日期：1983-12-01 00:00:00
abstract：:The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01199053
更新日期：1994-12-01 00:00:00
abstract：:Bifunctional dihaem cytochrome c thiosulfate dehydrogenases/tetrathionate reductases (TsdA) exhibit different catalytic properties depending on the source organism. In the human food-borne intestinal pathogen Campylobacter jejuni, TsdA functions as a tetrathionate reductase enabling respiration with tetrathionate as a...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160457
更新日期：2016-12-09 00:00:00
abstract：:MicroRNA-326 (miR-326) was reported to be dysregulated and involved in the progression of multiple cancers. However, the clinical significance, biological role and underlying mechanism of miR-326 in the carcinogenesis of breast cancer are still unclear. In the present study, we showed that miR-326 was down-regulated i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190787
更新日期：2019-07-29 00:00:00
abstract：:Perfusion of Langendorff rat hearts with [14C]adenosine yields an acid-insoluble, radioactive product whose concentration falls during ischaemia. The properties of the substance show that it is a polyribonucleotide. It is suggested that it may be mitochondrial poly A acting as a storage form of adenine nucleotides. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117435
更新日期：1985-01-01 00:00:00
abstract：:31P NMR studies on microorganisms have been carried out with the cells embedded in agarose gel. The novel use of the gel for the NMR studies has advantages over the usual liquid suspensions in terms of improved reproducibility of data and cell viability, with no net loss of spectral quality. Polyphosphate formation in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117011
更新日期：1981-02-01 00:00:00
abstract：:Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170105
更新日期：2017-05-17 00:00:00
abstract：:We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01201001
更新日期：1996-02-01 00:00:00
