Abstract:
:Perfusion of Langendorff rat hearts with [14C]adenosine yields an acid-insoluble, radioactive product whose concentration falls during ischaemia. The properties of the substance show that it is a polyribonucleotide. It is suggested that it may be mitochondrial poly A acting as a storage form of adenine nucleotides.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Fitt PS,Korecky B,Sharma Ndoi
10.1007/BF01117435subject
Has Abstractpub_date
1985-01-01 00:00:00pages
7-12issue
1eissn
0144-8463issn
1573-4935journal_volume
5pub_type
杂志文章abstract::Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202346
更新日期:2020-09-30 00:00:00
abstract::Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1010425932561
更新日期:2001-02-01 00:00:00
abstract::The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170186
更新日期:2017-06-27 00:00:00
abstract::The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181857
更新日期:2018-12-11 00:00:00
abstract::Using both immunohistological study and photoaffinity labelling with radioactive azido-ATP, evidence is presented that the mitochondrial membranes of the brown adipose tissue of the human adult contain a 32 000-Mr uncoupling protein, which is probably similar to the uncoupling protein of BAT of rodents. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01120989
更新日期:1983-08-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in ca...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20180915
更新日期:2018-10-09 00:00:00
abstract::Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20180323
更新日期:2018-08-29 00:00:00
abstract::In the present study, we investigated the role of lncRNA SAMMSON in hepatocellular carcinoma (HCC). We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. miR-9-3p was down-regulated in HCC tiss...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190615
更新日期:2019-07-05 00:00:00
abstract::The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171056
更新日期:2017-11-17 00:00:00
abstract::Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180243
更新日期:2018-12-07 00:00:00
abstract::Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01204353
更新日期:1995-12-01 00:00:00
abstract::The first demonstration of a method to incorporate radiolabeled methyl groups from [14C]formaldehyde into membrane proteins in human erythrocytes by reductive methylation in the presence of NaCNBH3 is described. This method is based on the work of Jentoft and Dearborn [(1979) J. Biol. Chem. 254, 4359-4365], who demons...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01136722
更新日期:1982-04-01 00:00:00
abstract::In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01128818
更新日期:1984-09-01 00:00:00
abstract::The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01199053
更新日期:1994-12-01 00:00:00
abstract::Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200799
更新日期:2020-06-26 00:00:00
abstract::Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01140499
更新日期:1984-04-01 00:00:00
abstract::Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181176
更新日期:2018-10-09 00:00:00
abstract::Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20193220
更新日期:2019-10-30 00:00:00
abstract::In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integr...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-007-9036-1
更新日期:2007-06-01 00:00:00
abstract::The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were allocated into three groups with three replicates. Group (1) kep...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20194296
更新日期:2020-03-27 00:00:00
abstract:BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200767
更新日期:2021-01-04 00:00:00
abstract::High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of th...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160174
更新日期:2016-09-16 00:00:00
abstract::Background: Many epidemiologic studies have explored the association between age at last birth (ALB) and the risk of epithelial ovarian cancer, but the results remain controversial. Methods: A literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and WanFang Med Onli...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20182035
更新日期:2019-09-13 00:00:00
abstract::Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116851
更新日期:1990-02-01 00:00:00
abstract::The cytosolic Ca2+ activity of insulin-releasing clonal cells (RINm5F) was studied with the intracellular fluorescent indicator quin-2. When the extracellular Ca2+ concentration was 1 mM, the basal cytosolic Ca2+ activity was 101 +/- 5 nM. Depolarization with 25 mM K+ increased this Ca2+ activity to at least 318 nM, a...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01140663
更新日期:1983-10-01 00:00:00
abstract::Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180411
更新日期:2018-10-17 00:00:00
abstract::Bifunctional dihaem cytochrome c thiosulfate dehydrogenases/tetrathionate reductases (TsdA) exhibit different catalytic properties depending on the source organism. In the human food-borne intestinal pathogen Campylobacter jejuni, TsdA functions as a tetrathionate reductase enabling respiration with tetrathionate as a...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160457
更新日期:2016-12-09 00:00:00
abstract::Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180914
更新日期:2018-10-31 00:00:00
abstract::In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191835
更新日期:2019-11-29 00:00:00
abstract::One of the major obstacles to obtaining human cells of a defined and reproducible standard suitable for use as medical therapies is the necessity for FCS (fetal calf serum) media augmentation in routine cell culture applications. FCS has become the supplement of choice for cell culture research, as it contains an arra...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20100064
更新日期:2011-06-01 00:00:00