Abstract：
:Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the number of water molecules that come out of the channel in transitions between various "open" to "closed" states. The loss of osmotic activity, due to the partial or completely unrestricted admission of small polymers becomes a measure of the transfer probabilities of polymers from solution to small cavities; it provides an opportunity to study polymer conformation in a perfectly sieved preparation. Current fluctuations due to the partial blockage by a transient polymer are converted into estimates of times of passage and diffusion constants of polymers in channels. These estimates show how a channel whose functional states last for milliseconds is able to average over the interactions with polymers, interactions that last only microseconds. One sees clearly that in this averaging, the macromolecular channel is large enough to react like a macroscopic object to the chemical potentials of the species that modulate its activity.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Parsegian VA,Bezrukov SM,Vodyanoy Idoi
10.1007/BF01204353subject
Has Abstractpub_date
1995-12-01 00:00:00pages
503-14issue
6eissn
0144-8463issn
1573-4935journal_volume
15pub_type
杂志文章abstract：:Bladder cancer is a common malignant tumour worldwide. Epithelial-mesenchymal transition (EMT)-related biomarkers can be used for early diagnosis and prognosis of cancer patients. To explore, accurate prediction models are essential to the diagnosis and treatment for bladder cancer. In the present study, an EMT-relate...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203944
更新日期：2021-01-29 00:00:00
abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201199
更新日期：2020-06-26 00:00:00
abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. METHODS:The robust rank aggregation method was used to mine differentially expressed genes...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203973
更新日期：2021-01-29 00:00:00
abstract：:To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160104
更新日期：2016-09-16 00:00:00
abstract：OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20191519
更新日期：2019-11-29 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181304
更新日期：2018-12-21 00:00:00
abstract：:Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190562
更新日期：2019-07-08 00:00:00
abstract：:MicroRNAs (miRNAs) have been frequently identified as key mediators in almost all developmental and pathological processes, including those in the liver. The present study was conducted with aims of investigating the role of microRNA-138 (miR-138) in acute liver failure (ALF) via a mechanism involving p53 and liver ma...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190763
更新日期：2019-07-18 00:00:00
abstract：:Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (RRBP1) has been shown to participate in various aspects of malignancies. The clinical significance of RRBP1 and its involvement in the epithelial ovarian cancer have yet to be studied. The aim of the present study was to investigate the ...
journal_title：Bioscience reports
pub_type： 临床试验,杂志文章
doi：10.1042/BSR20190656
更新日期：2019-07-23 00:00:00
abstract：:Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114759
更新日期：1986-07-01 00:00:00
abstract：:Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus--a tissue culture-adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117442
更新日期：1985-01-01 00:00:00
abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200041
更新日期：2020-02-28 00:00:00
abstract：:Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01200213
更新日期：1995-02-01 00:00:00
abstract：:Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201232
更新日期：2020-06-26 00:00:00
abstract：:This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01788370
更新日期：1995-10-01 00:00:00
abstract：:The human DEK proto-oncogene has been found to play an important role in autoimmune disease, viral infection and human carcinogenesis. Although it is transcriptionally up-regulated in cervical cancer, its intracellular function and regulation is still unexplored. In the present study, DEK and IκBα [inhibitor of NF-κB ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20100141
更新日期：2012-06-01 00:00:00
abstract：:Identified and cloned in 1996 for the first time, G protein-coupled oestrogen receptor (ER) 30 (GPR30/GPER) has been a hot spot in the field of sex hormone research till now. In the present study, we examined the effects of low-dose oestradiol (E2) combined with G15, a specific antagonist of GPR30 on ovariectomy (OVX)...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20150146
更新日期：2015-07-03 00:00:00
abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180731
更新日期：2018-10-22 00:00:00
abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for G protein alpha-subunits and are thought to be responsible for rapid deactivation of G protein mediated signaling pathway. In this present study, we demonstrate that PA is the most efficient candidate to inhibit GAP activity of RG...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/b:bire.0000007694.71158.02
更新日期：2003-08-01 00:00:00
abstract：:Calmodulin (CaM)-like activity was detected in human serum and foetal calf serum, with an activity 10 times more than that detectable in plasma. Serum CaM was largely accounted for by release from human platelets as confirmed by both radioimmunoassay and sodium-dodecyl-sulphate/polyacrylamide-gel electrophoresis of Ca...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01121017
更新日期：1984-08-01 00:00:00
abstract：:Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200799
更新日期：2020-06-26 00:00:00
abstract：:Accumulating evidence demonstrates that long non-coding RNAs (LncRNAs) play important roles in regulating gene expression and are involved in various cancers, including colorectal cancer (CRC). However, LncRNA profiles in CRC remain largely unknown. The present study aims to find the key LncRNA associated with CRC and...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160048
更新日期：2016-05-06 00:00:00
abstract：:Our study aimed at exploring the effects of miR-211 on the proliferation and apoptosis of lens epithelial cells in diabetic cataract mice by targetting NAD+-dependent histone deacetylase sirtulin 1 (SIRT1). Healthy male mice were assigned into normal and diabetic cataract groups. Blood glucose, lens turbidity, and apo...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170695
更新日期：2017-07-27 00:00:00
abstract：OBJECTIVE:To study the correlation between adenomatous polyposis coli (APC) gene 3' untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer (CRC) in a Chinese Han population. METHODS:Genotypes of APC gene 3'UTR rs1804197, rs41...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192429
更新日期：2020-03-27 00:00:00
abstract：:A major cause of failure in chemotherapy is drug resistance of cancer cells. Exosomes have been introduced to spread chemoresistance through delivering miRNAs. However, a systematic evaluation of the exosomal miRNA expression profiles responsible for chemoresistance is still lacking. In the present study, miRNA signat...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181090
更新日期：2018-11-15 00:00:00
abstract：:Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190016
更新日期：2019-04-16 00:00:00
abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181658
更新日期：2019-03-22 00:00:00
abstract：:Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study was to quantitatively assess these associations. PubMed, EMBASE, and Web of Science databases were systematically searched for eligi...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201008
更新日期：2020-07-31 00:00:00
abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117013
更新日期：1981-02-01 00:00:00
abstract：:In a study of Necturus gallbladder epithelium Benzel et al. (Benzel et al., 1980) found that low (0.2-1.2 microM) and higher concentrations (1.5 microM and more) of cytochalasin B (CB) caused an increase and decrease in the transepithelial electrical resistance (TER), respectively. Moreover, there were slight changes ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01855015
更新日期：1996-08-01 00:00:00
