Abstract:
:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the diagnosis, prognosis, and treatment of UA remains a challenge in the clinic. A global metabolomics research based on ultra-performance liquid chromatography (UPLC) combined with Q-TOF/MS was performed to discover the metabolic profile of health controls, UA patients, and UA patients with diabetes mellitus (DM), and screen for potential biomarkers. Twenty-seven potential biomarkers were determined using pattern recognition. These biomarkers, which include free fatty acids, amino acids, lysoPE and lysoPC species, and organic acids, can benefit the clinical diagnosis of UA. Pathway analysis indicated that arginine and proline metabolism, glycerophospholipid metabolism, and purine metabolism were affected in the UA patients, uniquely. Additionally, alterations in the metabolic signatures between UA and UA-complicated DM were also explored. As a result, six differential metabolites with an area under the curve (AUC) of more than 0.85 were identified as biomarkers for the diagnosis of UA and UA complicated with DM. Pathway analysis implied tryptophan metabolism was a key metabolic pathway in UA patients with DM, which provides new insights into the pathological study and drug discovery of UA.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Wang J,Xu W,Zhao H,Chen J,Zhu B,Li X,Deng D,Wang J,Liu J,Yu Y,Xiao H,Wang Wdoi
10.1042/BSR20181658subject
Has Abstractpub_date
2019-03-22 00:00:00issue
3eissn
0144-8463issn
1573-4935pii
BSR20181658journal_volume
39pub_type
杂志文章abstract::Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180411
更新日期:2018-10-17 00:00:00
abstract::Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the uncoupling protein yielded five positive clones, pUCPr...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145183
更新日期:1986-01-01 00:00:00
abstract::Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01118600
更新日期:1991-02-01 00:00:00
abstract::Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
更新日期:2019-02-19 00:00:00
abstract::Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122130
更新日期:1987-12-01 00:00:00
abstract::Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114811
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. OBJECTIVE:To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus (NP) cell apoptosis and NP matrix catabolism, and its potential mechani...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180018
更新日期:2018-02-13 00:00:00
abstract::Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed that purified recombinant YjhC forms Neu5Ac from two dehydrated forms of this compound, 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-ac...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200927
更新日期:2020-06-26 00:00:00
abstract::The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122722
更新日期:1987-01-01 00:00:00
abstract::Fatty-acid synthesis has been measured in vivo with 3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122453
更新日期:1983-03-01 00:00:00
abstract::The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently...
journal_title:Bioscience reports
pub_type: 杂志文章,收录出版
doi:10.1042/BSR20171184
更新日期:2018-01-19 00:00:00
abstract::The recognition of phosphate and sulphate esters of tyrosine residues has been studied employing antisera with specificity for tyrosine phosphate, and the enzymes aryl sulphatase, and acid and alkaline phosphatases. The ability of tyrosine phosphate, and of phosphate esters of phenol, to inhibit the antiserum was pH d...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115155
更新日期:1986-03-01 00:00:00
abstract::Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new system to study PCD in plants; namely, leaf epidermal peels. The peel represents a monolayer consisting of cells of two types: phototrophi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1025576307912
更新日期:2003-04-01 00:00:00
abstract::The condensing component of chicken liver fatty acid synthetase is inhibited by a sulfhydryl reagent, iodoacetamide, with a second-order rate constant of 0.23 M-1 sec-1 at pH 7.0 and 0 degrees. Complete inactivation requires the modification of approximately 8 -SH groups per dimer of the enzyme. Quantitation of the ex...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116383
更新日期:1982-03-01 00:00:00
abstract::We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181556
更新日期:2019-01-08 00:00:00
abstract::The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170707
更新日期:2017-07-07 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202346
更新日期:2020-09-30 00:00:00
abstract::Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20193220
更新日期:2019-10-30 00:00:00
abstract::ATP-dependent chromatin remodeling proteins use the energy released from ATP hydrolysis to reposition nucleosomes in DNA-dependent processes. These proteins are classified as SF2 helicases. SMARCAL1, a member of this protein family, is known to modulate both DNA repair and transcription by specifically recognizing DNA...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180568
更新日期:2018-06-27 00:00:00
abstract:AIM:The purpose of the present study was to explore the function and mechanism of tensin 1 (TNS1) in non-small cell lung cancer (NSCLC) progression. METHODS:The expression of TNS1 in NSCLC cells and tissues was assessed by RT-PCR and Western blot. Besides, Kaplan-Meier survival analysis was recruited to explore the as...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201539
更新日期:2021-01-29 00:00:00
abstract::We aimed to determine the effect of 'Xiaozeng No. 1' (XZ-1) on cellular apoptosis changes of gastric epithelial dysplasia (GED) and to explore the underlying mechanism. Specimens taken from the pyloric area of the stomachs from rats in each group were subjected to Hematoxylin and Eosin (H&E) staining for pathological ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171529
更新日期:2018-06-12 00:00:00
abstract::LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distinguished OA patients...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190404
更新日期:2019-06-07 00:00:00
abstract::The inhibition of passive K+ influx into human red blood cells (RBC) by loop diuretics was found to be dependent on the external Na+ concentration. In the absence of external Na+, there was minimal inhibition but the influx remained dependent on Cl- ions. Thus, raising the external Na+ concentration increased the affi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116900
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVE:The role of lncRNAs in tumor has been widely concerned. The present study took HAS2-AS1 (the antisense RNA 1 of HAS2) as a starting point to explore its expression in glioma and its role in the process of migration and invasion, providing a strong theoretical basis for mining potential therapeutic targets of ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200487
更新日期:2020-08-28 00:00:00
abstract::Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180854
更新日期:2018-11-09 00:00:00
abstract::Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122227
更新日期:1984-06-01 00:00:00
abstract::The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190083
更新日期:2019-04-02 00:00:00
abstract::We investigated the possible translational role which elevated concentrations of highly purified Semliki Forest virus (SFV) capsid (C)-protein molecules may play in a cell-free translation system. Here we demonstrate that in the absence of double-stranded RNA high concentrations of C protein triggered the phosphorylat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01198464
更新日期:1996-12-01 00:00:00
abstract::In rats fed a normal (22% protein) diet, injection of clenbuterol (1 mg/kg/d for 21 d) did not affect energy intake, energy expenditure or weight gain, but reduced energetic efficiency, and fat and energy gains and increased body protein content. Presenting a low-protein (8%) diet reduced energy intake, gain and effic...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122126
更新日期:1987-12-01 00:00:00
abstract::Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117071
更新日期:1985-07-01 00:00:00