Osteoprotective effect of combination therapy of low-dose oestradiol with G15, a specific antagonist of GPR30/GPER in ovariectomy-induced osteoporotic rats.

abstract：:A model explaining quantal Ca2+ release as an intrinsic property of the inositol 1,4,5-triphosphate (IP3) receptor has been put forward. The model is based on the hypothesis that the IP3 receptor can catalyze a transformation of the IP3 molecule differing from its conventional metabolism. A simple kinetic mechanism is...

journal_title：Bioscience reports

authors： Kaimachnikov NP,Nazarenko VG

更新日期：1996-10-01 00:00:00

abstract：:BRL 26830 is a thermogenic beta-adrenoceptor agonist which stimulates lipolysis and fatty acid oxidation in vivo. It also stimulates insulin secretion, and hence promotes glucose utilisation in vivo. The effect of this agent on white and brown adipose tissue of the rat was investigated. BRL 26830 increased the rate of...

journal_title：Bioscience reports

authors： Wilson S

更新日期：1989-02-01 00:00:00

abstract：:Immobilization of yeast mitochondrial RNA on nitrocellulose filters without prior alkali treatment revealed a low-MW RNA species (integral of 300 bases) which hybridizes specifically to the RNA coding strand of a DNA fragment BglII-HinfI at the 3' end of the COB-BOX gene. This RNA species (often a doublet) was found i...

journal_title：Bioscience reports

authors： Halbreich A,Grandchamp C,Foucher M

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate...

journal_title：Bioscience reports

authors： Yi S,Xu J,Shi H,Li W,Li Q,Sun YP

更新日期：2020-06-26 00:00:00

abstract：:Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the uncoupling protein yielded five positive clones, pUCPr...

journal_title：Bioscience reports

authors： Ridley RG,Patel HV,Parfett CL,Olynyk KA,Reichling S,Freeman KB

更新日期：1986-01-01 00:00:00

abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...

journal_title：Bioscience reports

authors： Wang J,Xu W,Zhao H,Chen J,Zhu B,Li X,Deng D,Wang J,Liu J,Yu Y,Xiao H,Wang W

更新日期：2019-03-22 00:00:00

abstract：:Permeant cationic fluorescent probes are widely employed to monitor mitochondrial transmembrane potential and its changes. The application of such potential-dependent probes in conjunction with both fluorescence microscopy and fluorescence spectroscopy allows the monitoring of mitochondrial membrane potential in indiv...

journal_title：Bioscience reports

authors： Solaini G,Sgarbi G,Lenaz G,Baracca A

更新日期：2007-06-01 00:00:00

abstract：:Amphiphilic anionic peptides have been used to enhance the efficiency of transfection by helping plasmids to escape from endosomes to the cytosol. It has been shown that efficiency of an eicosamers containing five glutamyl residues (E5), can be considerably enhanced either by transforming it into a dimer or by adding ...

journal_title：Bioscience reports

authors： Freulon I,Monsigny M,Midoux P,Mayer R

更新日期：2000-10-01 00:00:00

abstract：:Erythrocytes suspended in a medium of low ionic strength lyse under the effect of an exponential electrical pulse. The percentage of haemolysed cells decreases several-fold in the presence of divalent cations. The protective action of the ions studied increases in the following order: Ca++, Mg++, Zn++. It is assumed t...

journal_title：Bioscience reports

authors： Tomov TC,Tsoneva IC,Doncheva JC

更新日期：1988-10-01 00:00:00

abstract：:Cathepsin D occurs in two forms, a single polypeptide chain (Mr 44 000) and a non-covalent complex of two peptides of Mr 14 000 and 30 000 that is derived by proteolytic processing of the 44 000 polypeptide. The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid env...

journal_title：Bioscience reports

authors： Pain RH,Lah T,Turk V

更新日期：1985-10-01 00:00:00

abstract：:Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...

journal_title：Bioscience reports

authors： Maercker C

更新日期：2005-02-01 00:00:00

abstract：:eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2-3 phosphates per eNOS monomer. Phosphorylation decreases NO synthesis...

journal_title：Bioscience reports

authors： Salerno JC,Ghosh DK,Razdan R,Helms KA,Brown CC,McMurry JL,Rye EA,Chrestensen CA

更新日期：2014-09-17 00:00:00

abstract：:Microvirin (MVN) is a carbohydrate-binding protein which shows high specificity for high-mannose type N-glycan structures. In the present study, we tried to identify whether MVN could bind to high-mannose containing hepatitis C virus (HCV) envelope glycoproteins, which are heavily decorated high-mannose glycans. In ad...

journal_title：Bioscience reports

authors： Min YQ,Duan XC,Zhou YD,Kulinich A,Meng W,Cai ZP,Ma HY,Liu L,Zhang XL,Voglmeir J

更新日期：2017-06-30 00:00:00

abstract：:Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 ...

journal_title：Bioscience reports

authors： Ding J,Liu L,Kong WK,Chen XB,Liu X

更新日期：2019-04-30 00:00:00

abstract：:When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, sig...

journal_title：Bioscience reports

authors： MacManus JP,Watson DC,Yaguchi M

更新日期：1983-11-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...

journal_title：Bioscience reports

authors： Barciszewska AM

更新日期：2018-10-22 00:00:00

abstract：OBJECTIVE:X inactivate-specific transcript (XIST) is an attractive long noncoding RNA (lncRNA) functioning as an indicator of various human tumors, including laryngeal squamous cell carcinoma (LSCC). The present study was conducted to explore a novel regulatory network of lncRNA XIST in LSCC cells. MATERIALS AND METHO...

journal_title：Bioscience reports

authors： Liu C,Lu Z,Liu H,Zhuang S,Guo P

更新日期：2020-04-30 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...

journal_title：Bioscience reports

authors： Yu M,Hou J,Zheng M,Cao Y,Alike Y,Mi Y,Zhu J

更新日期：2020-01-31 00:00:00

abstract：:This paper presents a short review of our contribution to the knowledge of the structure and function of human C1r, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of C1r, a model accounting for its autolytic activation mechanism is proposed. ...

journal_title：Bioscience reports

authors： Arlaud GJ,Colomb MG,Villiers CL

更新日期：1985-10-01 00:00:00

abstract：:Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...

journal_title：Bioscience reports

authors： Sengupta T,Koklic T,Lentz BR,Majumder R

更新日期：2021-01-22 00:00:00

abstract：:Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...

journal_title：Bioscience reports

authors： Zhou L,Xiao X

更新日期：2018-04-13 00:00:00

abstract：:To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and f...

journal_title：Bioscience reports

authors： Gong L,Tang Y,Jiang L,Tang W,Luo S

更新日期：2020-12-23 00:00:00

abstract：:A slow phase of linear exocytosis by fibroblasts of previously endocytosed fluid, succeeding the initial burst of release, is described. This is not due to cell lysis, is virtually abolished at 4 degrees C, and is retarded when the lysosomal system is expanded. It may reflect membrane recycling. ...

journal_title：Bioscience reports

authors： Dean RT,Jessup W

更新日期：1982-08-01 00:00:00

abstract：AIM:IgA nephropathy (IgAN) is one of the most common chronic glomerulonephritis. Its etiology and pathogenesis remain unclear. We thus explored the immune repertoire of the B-cell receptor (BCR) and the heavy-chain complementarity-determining region 3 (CDR3) in renal tissue and peripheral blood of IgAN patients. METHO...

journal_title：Bioscience reports

authors： Chen D,Zhang Z,Yang Y,Hong Q,Li W,Zhuo L

更新日期：2019-10-30 00:00:00

abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...

journal_title：Bioscience reports

authors： Odedra BR,Palmer TN

更新日期：1981-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in the oral cavity, which accounts for >90% of all diagnosed oral cancers. 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed...

journal_title：Bioscience reports

authors： Jiang L,Xiao J

更新日期：2020-03-27 00:00:00

abstract：:Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors...

journal_title：Bioscience reports

authors： Chen G,Chen W,Ye M,Tan W,Jia B

更新日期：2019-01-18 00:00:00

abstract：:Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

journal_title：Bioscience reports

authors： Tian S,Xing YN,Xia P

更新日期：2018-10-31 00:00:00

abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...

journal_title：Bioscience reports

authors： Abate F,Malito E,Cozzi R,Lo Surdo P,Maione D,Bottomley MJ

更新日期：2014-11-24 00:00:00