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Calmodulin in human serum and the specific release of calmodulin from calmodulin-rich platelets.

Abstract：

:Calmodulin (CaM)-like activity was detected in human serum and foetal calf serum, with an activity 10 times more than that detectable in plasma. Serum CaM was largely accounted for by release from human platelets as confirmed by both radioimmunoassay and sodium-dodecyl-sulphate/polyacrylamide-gel electrophoresis of CaM partially purified from platelet releasate obtained in response to thrombin. Lactate dehydrogenase release was unaffected by thrombin. Platelet CaM content was very variable (1.3 to 11.3 micrograms/mg protein; n = 15). It is suggested that intact platelets are rich in CaM and that release of CaM during preparation explains the variation in CaM content reported here and in the literature.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Mac Neil S,Walker SW,Seid J,Tomlinson S

doi

10.1007/BF01121017

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

643-50

issue

8

eissn

0144-8463

issn

1573-4935

journal_volume

4

pub_type

杂志文章

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