Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors.

abstract：:Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values ...

journal_title：Bioscience reports

authors： Ohaeri OC

更新日期：2001-02-01 00:00:00

abstract：:Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diagnosis and treatment...

journal_title：Bioscience reports

authors： Li H,He J,Yi H,Xiang G,Chen K,Fu B,Yang Y,Chen G

更新日期：2015-03-18 00:00:00

abstract：:Mitochondrial genome is a powerful molecule marker to provide information for phylogenetic relationships and revealing molecular evolution in ichthyological studies. Sebastiscus species, a marine rockfish, are of essential economic value. However, the taxonomic status and phylogenetic relationships of Sebastidae have ...

journal_title：Bioscience reports

authors： Jia C,Zhang X,Xu S,Yang T,Yanagimoto T,Gao T

更新日期：2020-12-23 00:00:00

abstract：:Oral vaccination requires an antigen delivery vehicle to protect the antigen and to enhance translocation of the antigen to the mucosa-associated lymphoid tissue. A variety of antigen delivery vehicles including liposomes have been studied for mucosal immunization. The advantages of liposome formulations are their par...

journal_title：Bioscience reports

authors： Zho F,Neutra MR

更新日期：2002-04-01 00:00:00

abstract：:Chemical transformations, like osmotic translocations, are transport processes when looked at in detail. In chemiosmotic systems, the pathways of specific ligand conduction are spatially orientated through osmoenzymes and porters in which the actions of chemical group, electron and solute transfer occur as vectorial (...

journal_title：Bioscience reports

authors： Mitchell PD

更新日期：2004-08-01 00:00:00

abstract：:We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...

journal_title：Bioscience reports

authors： Bonincontro A,Iacoangeli A,Melucci-Vigo G,Risuleo G

更新日期：1997-12-01 00:00:00

abstract：:Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...

journal_title：Bioscience reports

authors： Liu P,Zhuo Z,Li W,Cheng J,Zhou H,He J,Zhang J,Wang J

更新日期：2019-01-22 00:00:00

abstract：:Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions. Unlike the structural components of the ECM that form networks or fibrils, TSPs are deposited into ECM as arrays of nanoscale puncta. ...

journal_title：Bioscience reports

authors： Hellewell AL,Gong X,Schärich K,Christofidou ED,Adams JC

更新日期：2015-05-20 00:00:00

abstract：:Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...

journal_title：Bioscience reports

authors： Trchounian A,Kobayashi H

更新日期：2000-08-01 00:00:00

abstract：:Tuberculosis (TB) is a chronic infectious disease that has been threatening public health for many years. Several studies have shown the relationship between the macrophage migration inhibitory factor (MIF)-794 CATT (MIF-794 CATT) microsatellite polymorphism and susceptibility to TB. However, the results remain inconc...

journal_title：Bioscience reports

authors： Ma M,Tao L,Liu A,Liang Z,Yang J,Peng Y,Dai X,Bai R,Ji Z,Jian M,Bao F

更新日期：2018-07-06 00:00:00

abstract：:An increase in the permeability of outer mitochondrial membrane is central to apoptotic cell death, and results in the release of several apoptogenic factors such as cytochrome c into the cytoplasm to activate downstream destructive programs. The voltage-dependent anion channel (VDAC or mitochondrial porin) plays an e...

journal_title：Bioscience reports

authors： Tsujimoto Y

更新日期：2002-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in ca...

journal_title：Bioscience reports

authors： Ding B,Lou W,Xu L,Fan W

更新日期：2018-10-09 00:00:00

abstract：:Although radioactive iodine (131I) treatment (RIT) is recommended as the preferred option for patients with Graves' disease (GD), the predictive factors for its clinical outcomes are still unclear. In the present study, we aim to investigate the factors influencing the success rate of RIT treatment on primary GD with ...

journal_title：Bioscience reports

authors： Xing YZ,Zhang K,Jin G

更新日期：2020-01-31 00:00:00

abstract：:Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...

journal_title：Bioscience reports

authors： Zhang Z,Chang Y,Jia W,Zhang J,Zhang R,Zhu J,Yang T,Xia H,Zou Y,He J

更新日期：2018-02-08 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for G protein alpha-subunits and are thought to be responsible for rapid deactivation of G protein mediated signaling pathway. In this present study, we demonstrate that PA is the most efficient candidate to inhibit GAP activity of RG...

journal_title：Bioscience reports

authors： Ou-Yang YS,Tu Y,Yang F

更新日期：2003-08-01 00:00:00

abstract：:Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocar...

journal_title：Bioscience reports

authors： Zhang Y,Cheng J,Chen F,Wu C,Zhang J,Ren X,Pan Y,Nie B,Li Q,Li Y

更新日期：2017-03-27 00:00:00

abstract：:Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI congruent to 10(-6) M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS i...

journal_title：Bioscience reports

authors： Shennan DB,Boyd CA

更新日期：1986-10-01 00:00:00

abstract：:Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of the present study was to evaluate the MTHFR C6...

journal_title：Bioscience reports

authors： Xiong Y,Bian C,Lin X,Wang X,Xu K,Zhao X

更新日期：2020-07-31 00:00:00

abstract：:Human endothelial cells from the umbilical vein and skin fibroblasts can be separated by means of centrifugation in a density gradient of Percoll. Cells show a good recovery in culture. Viability is not impaired. ...

journal_title：Bioscience reports

authors： Sbarbati R

更新日期：1985-06-01 00:00:00

abstract：:Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...

journal_title：Bioscience reports

authors： Maercker C

更新日期：2005-02-01 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...

journal_title：Bioscience reports

authors： Sun G,Lu Y,Li Y,Mao J,Zhang J,Jin Y,Li Y,Sun Y,Liu L,Li L

更新日期：2017-12-05 00:00:00

abstract：:Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...

journal_title：Bioscience reports

authors： Hu Y,Zeng Q,Li C,Xie Y

更新日期：2019-05-02 00:00:00

abstract：:Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...

journal_title：Bioscience reports

authors： Yang ML,Huang Z,Wu LN,Wu R,Ding HX,Wang BG

更新日期：2019-07-12 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature ...

journal_title：Bioscience reports

authors： Feng X,Li L,Wang L,Luo S,Bai X

更新日期：2019-04-16 00:00:00

abstract：:NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels, the NOX2 isoform has been consid...

journal_title：Bioscience reports

authors： Macías-Pérez ME,Martínez-Ramos F,Padilla-Martínez II,Correa-Basurto J,Kispert L,Mendieta-Wejebe JE,Rosales-Hernández MC

更新日期：2013-08-02 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00

abstract：:Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled polypeptide. Secretion of the non-glycosylated protein ...

journal_title：Bioscience reports

authors： Bradshaw JP,White DA

更新日期：1985-03-01 00:00:00