Abstract：
:An increase in the permeability of outer mitochondrial membrane is central to apoptotic cell death, and results in the release of several apoptogenic factors such as cytochrome c into the cytoplasm to activate downstream destructive programs. The voltage-dependent anion channel (VDAC or mitochondrial porin) plays an essential role in disrupting the mitochondrial membrane barrier and is regulated directly by members of the Bcl-2 family proteins. Anti-apoptotic Bcl-2 family members interact with and close the VDAC, whereas some, but not all, proapoptotic members interact with VDAC to open protein-conducting pore through which apoptogenic factors pass. Although the VDAC is involved directly in breaking the mitochondrial membrane barrier and is a known component of the permeability transition pore complex, VDAC-dependent increase in outer membrane permeability can be independent of the permeability transition event such as mitochondrial swelling followed by rupture of the outer mitochondrial membrane. VDAC interacts not only with Bcl-2 family members but also with proteins such as gelsolin, an actin regulatory protein, and appears to be a convergence point for a variety of cell survival and cell death signals.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Tsujimoto Ydoi
10.1023/a:1016061006256keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
47-58issue
1eissn
0144-8463issn
1573-4935journal_volume
22pub_type
杂志文章,评审abstract：:Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20181275
更新日期：2018-12-07 00:00:00
abstract：:Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192712
更新日期：2020-02-28 00:00:00
abstract：:Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four s...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181696
更新日期：2018-11-28 00:00:00
abstract：:Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190304
更新日期：2019-07-08 00:00:00
abstract：:This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116615
更新日期：1990-12-01 00:00:00
abstract：:The role of the topoisomerase enzyme in DNA recombination was investigated by extracting chromosomal deoxyribonucleoproteins from a variety of cultured mammalian cells and assaying for the formation of recombinant DNA structures. Although each of the crude deoxyribonucleoprotein preparations contained topoisomerase ac...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01115252
更新日期：1982-07-01 00:00:00
abstract：:Triacylglycerol/fatty acid substrate cycling was measured in vivo in brown adipose tissue (BAT) and white adipose tissue (WAT) of fed, starved and refed rats. Starvation (24h) significantly decreased the rate of cycling in BAT, and refeeding chow diet led to a rapid, 6-fold increase in cycling. Cycling rate in WAT was...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116459
更新日期：1988-04-01 00:00:00
abstract：:Transfer of Bomirski amelanotic melanoma cells from in vivo to in vitro growth conditions results in occurrence of rapid melanization in their cytoplasm. The melanized cells from primary cell culture initiate tumours in hamsters, which do not contain traces of melanin and resemble typical amelanotic melanoma. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01121951
更新日期：1983-02-01 00:00:00
abstract：:The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01362501
更新日期：1987-05-01 00:00:00
abstract：:It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized haemolysed blood was higher than that in the fraction ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01136856
更新日期：1991-08-01 00:00:00
abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200041
更新日期：2020-02-28 00:00:00
abstract：:The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180793
更新日期：2019-01-08 00:00:00
abstract：:Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [35S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) increased their rate of protein synthesis, and the maxima...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01119479
更新日期：1987-11-01 00:00:00
abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01128818
更新日期：1984-09-01 00:00:00
abstract：:A non-ionic detergent such as Lubrol-PX extracts in soluble form the VIP-binding structures of rat liver plasma membranes. Detergent-solubilized proteins bind specifically [125I]VIP and the complex tracer-protein is identified by the use of Sepharose 6B columns. The interaction is only possible in the absence of deter...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01145177
更新日期：1986-01-01 00:00:00
abstract：:Bladder cancer is a common malignant tumour worldwide. Epithelial-mesenchymal transition (EMT)-related biomarkers can be used for early diagnosis and prognosis of cancer patients. To explore, accurate prediction models are essential to the diagnosis and treatment for bladder cancer. In the present study, an EMT-relate...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203944
更新日期：2021-01-29 00:00:00
abstract：:Immobilization of yeast mitochondrial RNA on nitrocellulose filters without prior alkali treatment revealed a low-MW RNA species (integral of 300 bases) which hybridizes specifically to the RNA coding strand of a DNA fragment BglII-HinfI at the 3' end of the COB-BOX gene. This RNA species (often a doublet) was found i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116301
更新日期：1981-07-01 00:00:00
abstract：:The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190091
更新日期：2019-04-16 00:00:00
abstract：:An adenosine 3'5'-cyclic-monophosphate (Cyclic AMP)-dependent protein kinase has been identified and partially purified from the rat prostate tumor induced by 20-methylcholanthrene. This enzyme is stimulated 2- to 3-fold by the nucleotide. Equilibrium studies at pH 5.0 suggest the presence of a major class of binding ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114829
更新日期：1982-09-01 00:00:00
abstract：:The effect of ligands (glucose, ATP and Mg2+) and zwitterionic micelles of lysophosphatidylcholine (LPC) or N-hexadecyl-N,N-dimethyl-3-ammonium propanesulfonate (HPS) in the yeast hexokinase (HK) stability was studied at 35 degrees C. The thermal inactivation kinetics followed one-exponential decay. The effect of liga...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1005583117296
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:X inactivate-specific transcript (XIST) is an attractive long noncoding RNA (lncRNA) functioning as an indicator of various human tumors, including laryngeal squamous cell carcinoma (LSCC). The present study was conducted to explore a novel regulatory network of lncRNA XIST in LSCC cells. MATERIALS AND METHO...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193172
更新日期：2020-04-30 00:00:00
abstract：:This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatil...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1020182404940
更新日期：2002-04-01 00:00:00
abstract：:This is the first report of its kind that well demonstrates that a lectin from Phytolacca americana [Pa-2 (P. americana lectin-2)] can also be intrinsically unordered, based on the results obtained by CD, tryptophan fluorescence, ANS (8-anilinonaphthalene-1-sulfonic acid) binding, acrylamide quenching, DLS (dynamic li...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20090035
更新日期：2009-11-23 00:00:00
abstract：:The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200975
更新日期：2020-06-26 00:00:00
abstract：:Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190708
更新日期：2019-07-12 00:00:00
abstract：:Incubation of adult rat cardiac myocytes with increasing glucose concentrations decreased phosphorylation (αThr172) and activity of AMPK (AMP-activated protein kinase). The effect could be demonstrated without measurable changes in adenine nucleotide contents. The glucose effect was additive to the decrease in AMPK ac...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20110075
更新日期：2012-06-01 00:00:00
abstract：:This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01788370
更新日期：1995-10-01 00:00:00
abstract：:C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20100094
更新日期：2011-08-01 00:00:00
abstract：:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01140499
更新日期：1984-04-01 00:00:00
abstract：:Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/qua...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192940
更新日期：2019-11-29 00:00:00
