Abstract:
:Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian cancer by Oncomine, Human Protein Atlas database and ULCAN database. Meanwhile, we found its coexpression gene by cBioPortal online tool and validated their expression in different ovarian cancer cells by western blot and reverse transcription quantitative PCR. Then, we also investigated their prognostic values via the Kaplan-Meier plotter database in different subtypes of ovarian cancer patients. The results demonstrated that SFN was found to be increased in ten various ovarian cancer datasets, compared with healthy tissues. Additionally, up-regulation of SFN expression is associated with age and cancer grades. The higher expression of SFN in all patients with ovarian cancers is significantly correlated with worse postprogression survival. In addition, high SFN expression is associated with significantly worse overall survival in patients who received chemotherapy contains gemcitabine, taxol, taxol+platin, paclitaxel and avastin. In human ovarian carcinoma SKOV3 and A2780 cells, the expression of SFN and its coexpression gene MICB were also increased at protein and mRNA levels compared with the normal ovarian epithelial cells. Based on above results, overexpression of SFN was correlated with the prognosis in ovarian cancer. The present study might be useful for better understanding the clinical significance of SFN mRNA.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Hu Y,Zeng Q,Li C,Xie Ydoi
10.1042/BSR20190100subject
Has Abstractpub_date
2019-05-02 00:00:00issue
5eissn
0144-8463issn
1573-4935pii
BSR20190100journal_volume
39pub_type
杂志文章abstract::Background: Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. Methods: In the present study, we genotyped four s...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181696
更新日期:2018-11-28 00:00:00
abstract::Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for G protein alpha-subunits and are thought to be responsible for rapid deactivation of G protein mediated signaling pathway. In this present study, we demonstrate that PA is the most efficient candidate to inhibit GAP activity of RG...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/b:bire.0000007694.71158.02
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abstract::Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2848-y
更新日期:2005-02-01 00:00:00
abstract::Huaier Granule, a type of traditional Chinese biomedical preparation (TCBP), is considered to be a promising adjuvant therapy for breast cancer. Although an analysis of the published literature has been performed, the exact effects and safety of Huaier Granule remains controversial. Therefore, a wide-ranging systemati...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202509
更新日期:2020-08-28 00:00:00
abstract::Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biologic...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20194202
更新日期:2020-02-28 00:00:00
abstract::Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181275
更新日期:2018-12-07 00:00:00
abstract::The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122722
更新日期:1987-01-01 00:00:00
abstract::Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116377
更新日期:1982-03-01 00:00:00
abstract::Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1010425932561
更新日期:2001-02-01 00:00:00
abstract::Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180770
更新日期:2018-08-31 00:00:00
abstract::Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170302
更新日期:2017-07-20 00:00:00
abstract::Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
更新日期:2019-02-19 00:00:00
abstract::Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20070012
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a tumor that is commonly found in southern China. NPC has several risk factors, such as infection with the Epstein-Barr virus. However, we know little about the risk factors for eye metastasis (EM) in male patients with NPC. Serum lipids are well recognized as risk factors f...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201082
更新日期:2020-06-26 00:00:00
abstract::When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, sig...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121034
更新日期:1983-11-01 00:00:00
abstract::Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regul...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182196
更新日期:2019-07-10 00:00:00
abstract::Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145960
更新日期:1993-04-01 00:00:00
abstract::To the best of our knowledge, this is the first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction nomogram for patients with LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations of the survival probability when com...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200228
更新日期:2020-08-28 00:00:00
abstract::Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our s...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160082
更新日期:2016-12-05 00:00:00
abstract::Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181658
更新日期:2019-03-22 00:00:00
abstract:AIM:The purpose of the present study was to explore the function and mechanism of tensin 1 (TNS1) in non-small cell lung cancer (NSCLC) progression. METHODS:The expression of TNS1 in NSCLC cells and tissues was assessed by RT-PCR and Western blot. Besides, Kaplan-Meier survival analysis was recruited to explore the as...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201539
更新日期:2021-01-29 00:00:00
abstract::Acidic airway microenvironment is one of the representative pathophysiological features of chronic inflammatory respiratory diseases. Epithelial barrier function is maintained by TJs (tight junctions), which act as the first physical barrier against the inhaled substances and pathogens of airway. As previous studies d...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20130087
更新日期:2013-10-31 00:00:00
abstract::More than 60 million people in the world have been diagnosed with HIV infections since the virus was recognized as the causative agent of AIDS in the 1980s. Even though more than half of the infected patients have died, effective disease treatment and prevention measures have not been established. ART (antiretroviral ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20140097
更新日期:2014-08-18 00:00:00
abstract::Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193431
更新日期:2020-03-27 00:00:00
abstract::HIV-1 infects host cells by sequential interactions of its fusion protein (gp120-gp41) with receptors CD4, CXCR4 and/or CCR5 followed by fusion of viral and host membranes. Studies indicate that additional factors such as receptor density and composition of viral and cellular lipids can dramatically modulate the fusio...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2894-5
更新日期:2005-10-01 00:00:00
abstract::This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116615
更新日期:1990-12-01 00:00:00
abstract::Three myoid-cell clones were established from the thymuses of two Wistar rats; one thymus yielded two clones, R615A and R615B2, and the other yielded one clone, R613Ad. The three clones were divided into two subtypes. Both subtypes were able to form myofibrils, expressed AChR on their cell-surface membrane, and contai...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116890
更新日期:1984-11-01 00:00:00
abstract::Cilia and flagella are critical organelles with conserved internal structures and diverse developmental and physiological processes according to cell type. Although the core components of structures are shared with thousands of associated proteins involved in cilia or flagella formation, we hypothesized that some unkn...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192666
更新日期:2020-01-31 00:00:00
abstract::Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200067
更新日期:2020-05-29 00:00:00
abstract::The concentration of carbonic anhydrase III (CAIII) in male rat liver was found to be 30 times greater than that in the female. Castration of male rats led to marked reduction in liver CAIII concentrations which could be partially restored to control levels by testosterone replacement. Marked developmental and senesce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121959
更新日期:1983-05-01 00:00:00