siRNA suppression of hTERT using activatable cell-penetrating peptides in hepatoma cells.

abstract：:Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...

journal_title：Bioscience reports

authors： Yao J,Zheng JS,Fu W,Zheng J

更新日期：2009-10-06 00:00:00

abstract：:An antibody was raised to the synthetic pentapeptide pGluHisProGlyLys which, in radioimmunoassay (RIA), could detect the pentapeptide at a level of 10 fmole per tube and exhibited less than 0.5 per cent cross reactivity with a series of related peptides. The RIA was used to demonstrate the presence of C-terminally ext...

journal_title：Bioscience reports

authors： Cockle SM,Smyth DG

更新日期：1986-06-01 00:00:00

abstract：RATIONALE:Houshiheisan (HSHS), a classic prescription in traditional Chinese medicine (TCM), has remarkable efficacy in the treatment of ischemic stroke. OBJECTIVE:To investigate the pro-angiogenic effect and molecular mechanism of HSHS for stroke recovery. METHODS AND RESULTS:The rat permanent middle cerebral artery...

journal_title：Bioscience reports

authors： Xiang Y,Yao X,Wang X,Zhao H,Zou H,Wang L,Zhang QX

更新日期：2019-10-30 00:00:00

abstract：:Stromal cell derived factor-1 (SDF-1) and basic fibroblast growth factor (bFGF) were reported to induce the differentiation of bone marrow stem cells (BMSCs) into cells with characteristics of periodontal ligament fibroblasts. Thus SDF-1 and bFGF may play a positive role in BMSCs-mediated periodontal ligament regenera...

journal_title：Bioscience reports

authors： Xu M,Wei X,Fang J,Xiao L

更新日期：2019-12-20 00:00:00

abstract：:Clustered Regularly Interspaced Short Palindromic Repeat activation-synergistic activation mediator system (CRISPRa-SAM) has been efficiently used to up-regulate the targeted genes in human and mouse. But it is not known whether the CRISPRa-SAM system can be used against porcine disease because its two important trans...

journal_title：Bioscience reports

authors： Jiang J,Sun Y,Xiao R,Wai K,Ahmad MJ,Khan FA,Zhou H,Li Z,Zhang Y,Zhou A,Zhang S

更新日期：2019-08-19 00:00:00

abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...

journal_title：Bioscience reports

authors： Wenger SL,Senft JR,Sargent LM,Bamezai R,Bairwa N,Grant SG

更新日期：2004-12-01 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity. These isoforms have long been considered to function in a redundant or comple...

journal_title：Bioscience reports

authors： Shinkai-Ouchi F,Shindo M,Doi N,Hata S,Ono Y

更新日期：2020-11-27 00:00:00

abstract：:Mice and rats are animals commonly used in research and laboratory testing. Compared with other animal species, they harbor many more zoonotic agents. Hymenolepis nana (H. nana) is a common tapeworm that parasitizes both humans and rodents. Although this tapeworm is of socio-economic importance worldwide, information ...

journal_title：Bioscience reports

authors： Metwally DM,Al-Enezy HA,Al-Turaiki IM,El-Khadragy MF,Yehia HM,Al-Otaibi TT

更新日期：2019-02-08 00:00:00

abstract：:To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and ...

journal_title：Bioscience reports

authors： He K,Qu H,Xu LN,Gao J,Cheng FY,Xiang P,Zhou CQ

更新日期：2016-09-16 00:00:00

abstract：:31P NMR studies on microorganisms have been carried out with the cells embedded in agarose gel. The novel use of the gel for the NMR studies has advantages over the usual liquid suspensions in terms of improved reproducibility of data and cell viability, with no net loss of spectral quality. Polyphosphate formation in...

journal_title：Bioscience reports

authors： Jacobson L,Cohen JS

更新日期：1981-02-01 00:00:00

abstract：:The recognition of phosphate and sulphate esters of tyrosine residues has been studied employing antisera with specificity for tyrosine phosphate, and the enzymes aryl sulphatase, and acid and alkaline phosphatases. The ability of tyrosine phosphate, and of phosphate esters of phenol, to inhibit the antiserum was pH d...

journal_title：Bioscience reports

authors： Jones JA,Wood A,Cushley W

更新日期：1986-03-01 00:00:00

abstract：:The unicellular Tetrahymena enzymatically split the synthetic phosphodiester, 4-methylumbelliferyl phosphocholine substrate. The enzyme activity was completely blocked in vitro and drastically inhibited in vivo by G-protein activating fluorides (NaF; AIF4- and BeF3-). The phospholipase A2 inhibitor, quinacrine, and th...

journal_title：Bioscience reports

authors： Kovács P,Csaba G

更新日期：1999-04-01 00:00:00

abstract：:Leishmaniasis is a group of infectious and non-contagious severe parasitic diseases, caused by protozoans of the Leishmania genus. Natural products characterize a rich source of prospective chemical entities for the development of new effective drugs for neglected diseases. Scientific evaluation of medicinal plants ha...

journal_title：Bioscience reports

authors： Almayouf MA,El-Khadragy MF,Awad MA,Al-Olayan EM

更新日期：2020-11-30 00:00:00

abstract：:High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of th...

journal_title：Bioscience reports

authors： Weikel KA,Cacicedo JM,Ruderman NB,Ido Y

更新日期：2016-09-16 00:00:00

abstract：:In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...

journal_title：Bioscience reports

authors： Sun H,Zhang J,Ma Y,Liu J

更新日期：2020-09-30 00:00:00

abstract：:Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...

journal_title：Bioscience reports

authors： Zhang L,Zhang P,Sun X,Zhou L,Zhao J

更新日期：2018-12-14 00:00:00

abstract：:The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

journal_title：Bioscience reports

authors： Xu SY,Song N,Xiao SJ,Gao TX

更新日期：2020-02-28 00:00:00

abstract：:Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...

journal_title：Bioscience reports

authors： Duñach M,Seigneuret M,Rigaud JL,Padrós E

更新日期：1986-11-01 00:00:00

abstract：:Native bovine parathyroid hormone (bPTH) was found to be readily cleaved with human leukocyte elastase to yield the fragments bPTH(1-41) and bPTH(42-84). These were then isolated by reverse-phase HPLC and characterised by gas-phase sequencing and amino acid analysis. The biological activities of these fragments were a...

journal_title：Bioscience reports

authors： Barling PM,Lowe C

更新日期：1987-01-01 00:00:00

abstract：:The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM)....

journal_title：Bioscience reports

authors： Popescu LM,Nutu O,Panoiu C

更新日期：1985-01-01 00:00:00

abstract：:Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biologic...

journal_title：Bioscience reports

authors： Wang J,Lou S,Huang X,Mo Y,Wang Z,Zhu J,Tian X,Shi J,Zhou H,He J,Ruan J

更新日期：2020-02-28 00:00:00

abstract：:Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

journal_title：Bioscience reports

authors： Zhao H,Liu M,Liu H,Suo R,Lu C

更新日期：2020-03-27 00:00:00

abstract：:This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...

journal_title：Bioscience reports

authors： Plat J,Baumgartner S,Houben T,Vreugdenhil ACE,Mensink RP,Lütjohann D,Shiri-Sverdlov R

更新日期：2018-10-31 00:00:00

abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

journal_title：Bioscience reports

authors： Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

更新日期：2018-02-12 00:00:00

abstract：:Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters in a Chinese MHD cohort. Accordingly, we re...

journal_title：Bioscience reports

authors： Wang T,Li Y,Wu H,Chen H,Zhang Y,Zhou H,Li H

更新日期：2020-08-28 00:00:00

abstract：:We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs s...

journal_title：Bioscience reports

authors： Navasa N,Rodríguez-Aparicio L,Ferrero MÁ,Monteagudo-Mera A,Martínez-Blanco H

更新日期：2013-05-24 00:00:00

abstract：:miR-155 has multiple functions in many physiological and pathological processes. However, little is known about the expression characteristics of avian miR-155. In the present study, partial pri-miR-155 sequences were cloned from AA+ broiler, Sanhuang broiler and Hy-Line Brown layer, respectively. Stem-loop qRT-PCR wa...

journal_title：Bioscience reports

authors： Xu S,Chang Y,Wu G,Zhang W,Man C

更新日期：2020-06-26 00:00:00

abstract：:The concentration of carbonic anhydrase III (CAIII) in male rat liver was found to be 30 times greater than that in the female. Castration of male rats led to marked reduction in liver CAIII concentrations which could be partially restored to control levels by testosterone replacement. Marked developmental and senesce...

journal_title：Bioscience reports

authors： Shiels A,Jeffery S,Phillips IR,Shephard EA,Wilson CA,Carter ND

更新日期：1983-05-01 00:00:00

abstract：:Chagas disease remains a serious health problem for countries where the most common mode of transmission is infection contracted from the feces of a Triatominae insect vector. In México, 32 species of Triatoma have been identified; amongst them, Triatoma (Meccus) pallidipennis is an endemic species reported to have hi...

journal_title：Bioscience reports

authors： Díaz-Garrido P,Sepúlveda-Robles O,Martínez-Martínez I,Espinoza B

更新日期：2018-09-28 00:00:00