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Polysialic and colanic acids metabolism in Escherichia coli K92 is regulated by RcsA and RcsB.

Abstract：

:We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs system is involved in the regulation of both CA and PA synthesis in E. coli K92. Deletion of either rcsA or rcsB genes resulted in decreased expression of cps (CA biosynthesis cluster) at 19°C and 37°C, but only CA production was reduced at 19°C. Concerning PA, both deletions enhanced its synthesis at 37°C, which does not correlate with the reduced kps (PA biosynthesis cluster) expression observed in the rcsB mutant. Under this condition, expression of the nan operon responsible for PA catabolism was greatly reduced. Although RcsA and RcsB acted as negative regulators of PA synthesis at 37°C, their absence did not reestablish PA expression at low temperatures, despite the deletion of rcsB resulting in enhanced kps expression. Finally, our results revealed that RcsB controlled the expression of several genes (dsrA, rfaH, h-ns and slyA) involved in the thermoregulation of CA and PA synthesis, indicating that RcsB is part of a complex regulatory mechanism governing the surface appearance in E. coli.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Navasa N,Rodríguez-Aparicio L,Ferrero MÁ,Monteagudo-Mera A,Martínez-Blanco H

doi

10.1042/BSR20130018

subject

Has Abstract

pub_date

2013-05-24 00:00:00

issue

3

eissn

0144-8463

issn

1573-4935

pii

BSR20130018

journal_volume

33

pub_type

杂志文章

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