Effect of the beta-adrenoceptor agonist BRL 26830 on fatty acid synthesis and on the activities of pyruvate dehydrogenase and acetyl-CoA carboxylase in adipose tissues of the rat.

abstract：:The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expres...

journal_title：Bioscience reports

authors： Zhang S,Wang Q,Han Q,Han H,Lu P

更新日期：2019-04-02 00:00:00

abstract：:Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...

journal_title：Bioscience reports

authors： Bellini T,Degani D,Matteuzzi M,Dallocchio F

更新日期：1990-02-01 00:00:00

abstract：:The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...

journal_title：Bioscience reports

authors： Jencks WP

更新日期：1995-10-01 00:00:00

abstract：:Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...

journal_title：Bioscience reports

authors： Hui J,Pang SW

更新日期：2019-02-19 00:00:00

abstract：:The concentration of carbonic anhydrase III (CAIII) in male rat liver was found to be 30 times greater than that in the female. Castration of male rats led to marked reduction in liver CAIII concentrations which could be partially restored to control levels by testosterone replacement. Marked developmental and senesce...

journal_title：Bioscience reports

authors： Shiels A,Jeffery S,Phillips IR,Shephard EA,Wilson CA,Carter ND

更新日期：1983-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of l...

journal_title：Bioscience reports

authors： Huang T,Wang J,Zhou Y,Zhao Y,Hang D,Cao Y

更新日期：2019-05-14 00:00:00

abstract：:To explore the effect and mechanism of LncRNA LUCAT1 in cervical cancer (CC). In the present study, 67 cases of CC patients and 60 healthy cases were selected as the research objects. CC patients were selected as the study group (SG) and healthy physical examination patients were selected as the control group (CG). LU...

journal_title：Bioscience reports

authors： Yang T,Xia S

更新日期：2020-04-30 00:00:00

abstract：:PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1+/- mice, Sirt1 mRNA expression was not changed but Sirt1 protein ...

journal_title：Bioscience reports

authors： Liu Q,Zhang Y,Yang S,Wu Y,Wang J,Yu W,Liu Y

更新日期：2017-12-12 00:00:00

abstract：:Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...

journal_title：Bioscience reports

authors： Du Y,Sun D,Li Y

更新日期：2020-12-23 00:00:00

abstract：:The network meta-analysis was conducted to compare the short-term efficacy of different single-drug targeted therapies in the treatment of renal cell carcinoma (RCC). We initially searched databases for randomized controlled trials (RCTs) on different single-drug targeted therapies in treating RCC. The meta-analysis c...

journal_title：Bioscience reports

authors： He HL,Yao WX

更新日期：2017-12-07 00:00:00

abstract：:NMR is ideal for characterizing non-enzymatic protein glycation, including AGEs (advanced glycation endproducts) underlying tissue pathologies in diabetes and ageing. Ribose, R5P (ribose-5-phosphate) and ADPR (ADP-ribose), could be significant and underinvestigated biological glycating agents especially in chronic inf...

journal_title：Bioscience reports

authors： Bullock PT,Reid DG,Ying Chow W,Lau WP,Duer MJ

更新日期：2014-04-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (MI/R) triggers a complicated chain of inflammatory reactions. Dexmedetomidine (Dex) has been reported to be important in myocardial disorders. We evaluated the role of Dex in MI/R injury via the silent information regulator factor 2-related enzyme 1 (SIRT1)/mammalian target of rapamyci...

journal_title：Bioscience reports

authors： Zhang X,Li Y,Wang Y,Zhuang Y,Ren X,Yang K,Ma W,Zhong M

更新日期：2020-05-29 00:00:00

abstract：:We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...

journal_title：Bioscience reports

authors： Jia Y,Zhao LM,Bai HY,Zhang C,Dai SL,Lv HL,Shan BE

更新日期：2019-01-08 00:00:00

abstract：:Background: Many epidemiologic studies have explored the association between age at last birth (ALB) and the risk of epithelial ovarian cancer, but the results remain controversial. Methods: A literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and WanFang Med Onli...

journal_title：Bioscience reports

authors： Wu Y,Sun W,Xin X,Wang W,Zhang D

更新日期：2019-09-13 00:00:00

abstract：:This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatil...

journal_title：Bioscience reports

authors： Xu Y,Yushmanov VE,Tang P

更新日期：2002-04-01 00:00:00

abstract：:Although radioactive iodine (131I) treatment (RIT) is recommended as the preferred option for patients with Graves' disease (GD), the predictive factors for its clinical outcomes are still unclear. In the present study, we aim to investigate the factors influencing the success rate of RIT treatment on primary GD with ...

journal_title：Bioscience reports

authors： Xing YZ,Zhang K,Jin G

更新日期：2020-01-31 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:Hypocaloric diet feeding reduced the mitochondrial protein content and whole tissue GDP-binding in interscapular brown adipose tissue from both virgin and lactating rats. A reduction in brown fat lipoprotein lipase activity was also detected in underfed virgin and lactating animals. These results indicate that lactati...

journal_title：Bioscience reports

authors： Villarroya F,Felipe A,Mampel T

更新日期：1986-07-01 00:00:00

abstract：:miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...

journal_title：Bioscience reports

authors： Sun G,Lu Y,Li Y,Mao J,Zhang J,Jin Y,Li Y,Sun Y,Liu L,Li L

更新日期：2017-12-05 00:00:00

abstract：:Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...

journal_title：Bioscience reports

authors： Liu G,Zhou J,Dong M

更新日期：2019-03-22 00:00:00

abstract：OBJECTIVE:Gastric cancer is the most common gastrointestinal malignancy in China and results from a combination of genetic and environmental factors. The present study was conducted to investigate the relationship between long noncoding RNA (lncRNA) materally expressed gene 3 (MEG3) single nucleotide polymorphisms (SNP...

journal_title：Bioscience reports

authors： Kong X,Yang S,Liu C,Tang H,Chen Y,Zhang X,Zhou Y,Liang G

更新日期：2020-11-27 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...

journal_title：Bioscience reports

authors： Tian F,Zheng Z,Zhang D,He S,Shen J

更新日期：2018-12-21 00:00:00

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：AIM:To explore the prognostic value of clusterin (CLU) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA). METHODS:Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR), and CLU protein level in tissue samples was detected through immunohistoch...

journal_title：Bioscience reports

authors： Wang X,Liu Y,Qin Q,Zheng T

更新日期：2020-02-28 00:00:00

abstract：:The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resu...

journal_title：Bioscience reports

authors： Wesslén N,Bergsten P,Hellman B

更新日期：1986-11-01 00:00:00

abstract：:One of the major obstacles to obtaining human cells of a defined and reproducible standard suitable for use as medical therapies is the necessity for FCS (fetal calf serum) media augmentation in routine cell culture applications. FCS has become the supplement of choice for cell culture research, as it contains an arra...

journal_title：Bioscience reports

authors： Bryan N,Andrews KD,Loughran MJ,Rhodes NP,Hunt JA

更新日期：2011-06-01 00:00:00

abstract：:The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...

journal_title：Bioscience reports

authors： Nawaz MH,Ferreira JC,Nedyalkova L,Zhu H,Carrasco-López C,Kirmizialtin S,Rabeh WM

更新日期：2018-02-21 00:00:00

abstract：:Members of the ADAM (a disintegrin and metalloproteinase) family of proteins possess a multidomain architecture which permits functionalities as adhesion molecules, signalling intermediates and proteolytic enzymes. ADAM8 is found on immune cells and is induced by multiple pro-inflammatory stimuli suggesting a role in ...

journal_title：Bioscience reports

authors： Hall T,Leone JW,Wiese JF,Griggs DW,Pegg LE,Pauley AM,Tomasselli AG,Zack MD

更新日期：2009-08-01 00:00:00

abstract：:Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...

journal_title：Bioscience reports

authors： Zhang J,Hu S,Li Y

更新日期：2019-08-13 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...

journal_title：Bioscience reports

authors： Yao Y,Zhang T,Qi L,Liu R,Liu G,Wang J,Song Q,Sun C

更新日期：2020-01-31 00:00:00