Abstract:
:Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female mice. Pups of Mex3c mutant dams die of starvation soon after birth. Milk contents are present in the alveoli but deficient in the ducts of the mammary glands in mutant mice. Mutant mice do not show prolactin or oxytocin deficiency. They also develop myoepithelial cells in the mammary glands. Mex3c is expressed in the mammary gland epithelium. Our data suggest that functional defects in mammary gland epithelium or myoepithelial cells could cause lactation defects.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Du Y,Sun D,Li Ydoi
10.1042/BSR20201285subject
Has Abstractpub_date
2020-12-23 00:00:00issue
12eissn
0144-8463issn
1573-4935pii
226939journal_volume
40pub_type
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