Quantal Ca2+ release and inactivation in a model of the inositol 1,4,5-trisphosphate receptor involving transformation of the ligand by the receptor.

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our s...

journal_title：Bioscience reports

authors： Ma F,Li W,Li X,Tran BH,Suguro R,Guan R,Hou C,Wang H,Zhang A,Zhu Y,Zhu Y

更新日期：2016-12-05 00:00:00

abstract：:The unicellular Tetrahymena enzymatically split the synthetic phosphodiester, 4-methylumbelliferyl phosphocholine substrate. The enzyme activity was completely blocked in vitro and drastically inhibited in vivo by G-protein activating fluorides (NaF; AIF4- and BeF3-). The phospholipase A2 inhibitor, quinacrine, and th...

journal_title：Bioscience reports

authors： Kovács P,Csaba G

更新日期：1999-04-01 00:00:00

abstract：:We have investigated the intramembranal ion traffic in apoptotic 3T6 cells in culture. Apoptosis was induced by various treatments, such as serum deprivation, high density growth and hydrogen peroxide at subnecrotic doses. Cell death was assessed by nucleosomal DNA fragmentation, single cell electrophoresis, immunoflu...

journal_title：Bioscience reports

authors： Bonincontro A,Iacoangeli A,Melucci-Vigo G,Risuleo G

更新日期：1997-12-01 00:00:00

abstract：:Cathepsin D occurs in two forms, a single polypeptide chain (Mr 44 000) and a non-covalent complex of two peptides of Mr 14 000 and 30 000 that is derived by proteolytic processing of the 44 000 polypeptide. The two forms from bovine spleen are closely similar in secondary structure content, in aromatic amino acid env...

journal_title：Bioscience reports

authors： Pain RH,Lah T,Turk V

更新日期：1985-10-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...

journal_title：Bioscience reports

authors： Zhang L,Zhang P,Sun X,Zhou L,Zhao J

更新日期：2018-12-14 00:00:00

abstract：:The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...

journal_title：Bioscience reports

authors： Pang Y,Wang W

更新日期：2018-12-11 00:00:00

abstract：:High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...

journal_title：Bioscience reports

authors： Holm J,Hansen SI,Høier-Madsen M

更新日期：1991-06-01 00:00:00

abstract：:Radioactivity from [14C] adenosine was linearly incorporated into tissue nucleotides in perfused rat hearts. All the TCA-extractable 14C was confined to the purine nucleoside phosphates for up to 1 h of perfusion. Radioactivity was also incorporated linearly into the TCA-insoluble fraction, which by 40 min accounted f...

journal_title：Bioscience reports

authors： Hutchinson WL,Bates DJ,Perrett D,Mowbray J

更新日期：1981-11-01 00:00:00

abstract：:Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a screening method for RBC vesicle shedding using the Ca(2+) ionophore...

journal_title：Bioscience reports

authors： Kostova EB,Beuger BM,Klei TR,Halonen P,Lieftink C,Beijersbergen R,van den Berg TK,van Bruggen R

更新日期：2015-04-16 00:00:00

abstract：:Cilia and flagella are critical organelles with conserved internal structures and diverse developmental and physiological processes according to cell type. Although the core components of structures are shared with thousands of associated proteins involved in cilia or flagella formation, we hypothesized that some unkn...

journal_title：Bioscience reports

authors： Li ZZ,Zhao WL,Wang GS,Gu NH,Sun F

更新日期：2020-01-31 00:00:00

abstract：:Thrombospondin-2 (THBS2) is a secreted protein overexpressed in numerous cancers and may function as a diagnostic tumor marker. The objective of the present study was to investigate the diagnostic performance of serum THBS2 in early stage non-small-cell lung cancer (NSCLC). Serum THBS2 and Cyfra21-1 level were evaluat...

journal_title：Bioscience reports

authors： Jiang YM,Yu DL,Hou GX,Jiang JL,Zhou Q,Xu XF

更新日期：2019-07-25 00:00:00

abstract：:Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cell...

journal_title：Bioscience reports

authors： Diao X,Yang D,Chen Y,Liu W

更新日期：2019-04-09 00:00:00

abstract：:Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) plays important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in...

journal_title：Bioscience reports

authors： Xu D,Yu J,Gao G,Lu G,Zhang Y,Ma P

更新日期：2018-02-02 00:00:00

abstract：:The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that f...

journal_title：Bioscience reports

authors： Hitchens GD,Kell DB

更新日期：1982-10-01 00:00:00

abstract：:Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/qua...

journal_title：Bioscience reports

authors： Xia D,Lai X,Wu K,Zhou P,Li L,Guo Z,Xu S

更新日期：2019-11-29 00:00:00

abstract：:Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI congruent to 10(-6) M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS i...

journal_title：Bioscience reports

authors： Shennan DB,Boyd CA

更新日期：1986-10-01 00:00:00

abstract：:Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters in a Chinese MHD cohort. Accordingly, we re...

journal_title：Bioscience reports

authors： Wang T,Li Y,Wu H,Chen H,Zhang Y,Zhou H,Li H

更新日期：2020-08-28 00:00:00

abstract：:An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...

journal_title：Bioscience reports

authors： Shanker G,Pieringer RA

更新日期：1985-07-01 00:00:00

abstract：:Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsens...

journal_title：Bioscience reports

authors： Martinelli SD,Roberts TJ

更新日期：1983-01-01 00:00:00

abstract：:Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. However, studies focusing on the roles of PFDN in gastric cancer (GC) remain limited. The present study aims to ev...

journal_title：Bioscience reports

authors： Yesseyeva G,Aikemu B,Hong H,Yu C,Dong F,Sun J,Zang L,Zheng M,Ma J

更新日期：2020-02-28 00:00:00

abstract：:Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...

journal_title：Bioscience reports

authors： Liu J,Tang T,Wang GD,Liu B

更新日期：2019-07-15 00:00:00

abstract：:Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...

journal_title：Bioscience reports

authors： Liu X,Gao H,Zhang J,Xue D

更新日期：2019-05-07 00:00:00

abstract：:Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the uncoupling protein yielded five positive clones, pUCPr...

journal_title：Bioscience reports

authors： Ridley RG,Patel HV,Parfett CL,Olynyk KA,Reichling S,Freeman KB

更新日期：1986-01-01 00:00:00

abstract：:Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new system to study PCD in plants; namely, leaf epidermal peels. The peel represents a monolayer consisting of cells of two types: phototrophi...

journal_title：Bioscience reports

authors： Samuilov VD,Lagunova EM,Kiselevsky DB,Dzyubinskaya EV,Makarova YV,Gusev MV

更新日期：2003-04-01 00:00:00

abstract：:Maclurin, the potent non-specific blood-group hemagglutinin present in extracts of Maclura pomifera, has been purified by a new biospecific affinity-chromatographic procedure. Additional studies have indicated that this hemagglutinin occurs as five closely related tetrameric protein isoforms derived from two non-coval...

journal_title：Bioscience reports

authors： Hearn MT,Smith PK,Mallia AK

更新日期：1982-04-01 00:00:00

abstract：:The nature of certain forms of memory is discussed in relation to neural networks and REM sleep. ...

journal_title：Bioscience reports

authors： Crick F

更新日期：1988-12-01 00:00:00

abstract：:Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...

journal_title：Bioscience reports

authors： Krasnov GS,Puzanov GA,Afanasyeva MA,Dashinimaev EB,Vishnyakova KS,Beniaminov AD,Adzhubei AA,Kondratieva TT,Yegorov YE,Senchenko VN

更新日期：2019-12-20 00:00:00

abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

journal_title：Bioscience reports

authors： Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

更新日期：2019-07-25 00:00:00

abstract：:Rodney Porter's separation of antibody molecules into Fab and Fc fragments engendered the notion that a single antibody polypeptide chain might be coded by two or more genes. This concept profoundly influenced the development of molecular immunology over the past 25 years. Our current knowledge of antibody gene organi...

journal_title：Bioscience reports

authors： Fleischman JB

更新日期：1985-10-01 00:00:00