Comparison of linoleate, palmitate and acetate metabolism in rat ventral prostate.

Abstract:

:Rat ventral prostate incorporated (1-14C)acetate, (1-14C)palmitate and (1-14C)linoleate into different phospholipids in a time-dependent process. The rate of incorporation into total phospholipids was higher with linoleate (10.0 nmol/g) than with either palmitate (5.8 nmol/g) or acetate (4.7 nmol/g). Predominant labelling with all the radioactive substrates assayed was found in choline glycerophospholipids (PC). The radioactive profiles for linoleate in the other ventral prostate phospholipids differed from those obtained with palmitate and acetate. Specifically linoleate was incorporated into inositol glycerophospholipids plus lysoethanolamine glycerophospholipids (PI + LPE) and not into sphingomyelin (SM), while palmitate and acetate incorporated into SM but not into PI + LPE. Acetate showed the highest oxidation to CO2 whereas no differences were observed in the radioactivity incorporated into CO2 from a saturated (palmitate) or an essential unsaturated fatty acid (linoleate). These studies also show zinc-dependence by the acetate to CO2 oxidation.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

del Hoyo N,Pulido JA,Carretero MT,Pérez-Albarsanz MA

doi

10.1007/BF01116858

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

105-12

issue

1

eissn

0144-8463

issn

1573-4935

journal_volume

10

pub_type

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