Abstract：
:More than 60 million people in the world have been diagnosed with HIV infections since the virus was recognized as the causative agent of AIDS in the 1980s. Even though more than half of the infected patients have died, effective disease treatment and prevention measures have not been established. ART (antiretroviral therapy) is the only proven HIV treatment that sustains the suppression of patient viraemia. Current routine approaches to treat HIV infections are targeted at developing vaccines that will induce humoral or cell memory immune responses. However, developing an effective vaccine has been challenging because the HIV mutates rapidly, which allows the virus to evade immune surveillances established against the previous strain. In addition, the virus is able to quickly establish a reservoir and treatment is difficult because of the general lack of knowledge about HIV immune response mechanisms. This review introduces common disease symptoms and the progression of HIV infection with a brief summary of the current treatment approaches. Different cellular immune responses against HIV are also discussed, with emphasis on a nanotechnology research that has focused on probing T-cell response to HIV infection. Furthermore, we discuss recent noteworthy nanotechnology updates on T-cell response screening that is focused on HIV infection. Finally, we review potential future treatment strategies based on the correlations between T-cell response and HIV infection.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Choi J,Jeong Y,Han HS,Lee KHdoi
10.1042/BSR20140097subject
Has Abstractpub_date
2014-08-18 00:00:00issue
4eissn
0144-8463issn
1573-4935pii
BSR20140097journal_volume
34pub_type
杂志文章,评审abstract：:Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain unclear. In our clinical experience, it is difficult to cure WMS-affected marmosets with severe hypoalbuminemia. Thus, the mechanisms underlying hypoalbuminemia in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190562
更新日期：2019-07-08 00:00:00
abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192345
更新日期：2020-01-31 00:00:00
abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170969
更新日期：2017-07-21 00:00:00
abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181794
更新日期：2019-07-25 00:00:00
abstract：:MicroRNA-326 (miR-326) was reported to be dysregulated and involved in the progression of multiple cancers. However, the clinical significance, biological role and underlying mechanism of miR-326 in the carcinogenesis of breast cancer are still unclear. In the present study, we showed that miR-326 was down-regulated i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190787
更新日期：2019-07-29 00:00:00
abstract：:This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116615
更新日期：1990-12-01 00:00:00
abstract：:Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114972
更新日期：1986-11-01 00:00:00
abstract：:Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181776
更新日期：2019-02-26 00:00:00
abstract：:Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181722
更新日期：2019-07-15 00:00:00
abstract：:Epilepsy is a common neurological disorder that affects mammalian species including human beings and dogs. In order to discover novel drugs for the treatment of canine epilepsy, multiomics data were analyzed to identify epilepsy associated genes. In this research, the original ranking of associated genes was obtained ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191247
更新日期：2019-09-06 00:00:00
abstract：:The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200975
更新日期：2020-06-26 00:00:00
abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20171438
更新日期：2018-02-12 00:00:00
abstract：:Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193431
更新日期：2020-03-27 00:00:00
abstract：:The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117101
更新日期：1986-09-01 00:00:00
abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181658
更新日期：2019-03-22 00:00:00
abstract：:Ca-ATPase activity in sarcoplasmic reticulum (SR) membranes isolated from skeletal muscles of the typical hibernator, the ground squirrel Spermophilus undulatus, is about 2-fold lower than that in SR membranes of rats and rabbits and is further decreased 2-fold during hibernation. The use of carbocyanine anionic dye S...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1015540909212
更新日期：2001-12-01 00:00:00
abstract：:The kinetics of the fusion process between erythrocyte ghosts, as induced by Sendai virus, were readily revealed by a simple fluorescence procedure previously employed to characterize the fusion of viruses with biological membranes. The method relies on the relief of fluorescence selfquenching of the membrane-inserted...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114971
更新日期：1986-11-01 00:00:00
abstract：:The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170186
更新日期：2017-06-27 00:00:00
abstract：:The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01199053
更新日期：1994-12-01 00:00:00
abstract：:HIV-1 infects host cells by sequential interactions of its fusion protein (gp120-gp41) with receptors CD4, CXCR4 and/or CCR5 followed by fusion of viral and host membranes. Studies indicate that additional factors such as receptor density and composition of viral and cellular lipids can dramatically modulate the fusio...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/s10540-005-2894-5
更新日期：2005-10-01 00:00:00
abstract：:Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01200213
更新日期：1995-02-01 00:00:00
abstract：:The increase in % phosphorylase a associated with muscle contraction is reversed after a few minutes despite continued contractile activity. The present study was undertaken to determine whether adrenaline can activate phosphorylase after deactivation has occurred during prolonged stimulation of contraction. We found ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01115118
更新日期：1982-05-01 00:00:00
abstract：:The discovery of genes that control cell division in yeast, and their relation to cancer, is reviewed. ...
journal_title：Bioscience reports
pub_type： 传,历史文章
doi：10.1023/a:1020918107706
更新日期：2002-06-01 00:00:00
abstract：:A major cause of failure in chemotherapy is drug resistance of cancer cells. Exosomes have been introduced to spread chemoresistance through delivering miRNAs. However, a systematic evaluation of the exosomal miRNA expression profiles responsible for chemoresistance is still lacking. In the present study, miRNA signat...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181090
更新日期：2018-11-15 00:00:00
abstract：:Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140012
更新日期：2014-04-01 00:00:00
abstract：:Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20171234
更新日期：2018-04-13 00:00:00
abstract：:Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific end...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201471
更新日期：2020-10-30 00:00:00
abstract：:miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170899
更新日期：2017-12-05 00:00:00
abstract：:Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114759
更新日期：1986-07-01 00:00:00
abstract：:To explore the effect and mechanism of LncRNA LUCAT1 in cervical cancer (CC). In the present study, 67 cases of CC patients and 60 healthy cases were selected as the research objects. CC patients were selected as the study group (SG) and healthy physical examination patients were selected as the control group (CG). LU...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200422
更新日期：2020-04-30 00:00:00
