The relationship between the chromophore moiety and the cation binding sites in bacteriorhodopsin.

abstract：:Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...

journal_title：Bioscience reports

authors： Zhang Z,Chang Y,Jia W,Zhang J,Zhang R,Zhu J,Yang T,Xia H,Zou Y,He J

更新日期：2018-02-08 00:00:00

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：:In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...

journal_title：Bioscience reports

authors： Sun H,Zhang J,Ma Y,Liu J

更新日期：2020-09-30 00:00:00

abstract：:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...

journal_title：Bioscience reports

authors： Rothwell NJ,Saville ME,Stock MJ

更新日期：1984-04-01 00:00:00

abstract：:A model explaining quantal Ca2+ release as an intrinsic property of the inositol 1,4,5-triphosphate (IP3) receptor has been put forward. The model is based on the hypothesis that the IP3 receptor can catalyze a transformation of the IP3 molecule differing from its conventional metabolism. A simple kinetic mechanism is...

journal_title：Bioscience reports

authors： Kaimachnikov NP,Nazarenko VG

更新日期：1996-10-01 00:00:00

abstract：:We investigated the possible translational role which elevated concentrations of highly purified Semliki Forest virus (SFV) capsid (C)-protein molecules may play in a cell-free translation system. Here we demonstrate that in the absence of double-stranded RNA high concentrations of C protein triggered the phosphorylat...

journal_title：Bioscience reports

authors： Favre D,Studer E,Michel MR

更新日期：1996-12-01 00:00:00

abstract：:A riboflavin carrier protein has been purified from human pregnancy and umbilical cord sera by affinity chromatography and fast protein liquid chromatography. This protein has a similar molecular weight to the chicken egg riboflavin carrier protein and shares other physicochemical properties, such as pI and riboflavin...

journal_title：Bioscience reports

authors： Visweswariah SS,Adiga PR

更新日期：1987-07-01 00:00:00

abstract：:The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both...

journal_title：Bioscience reports

authors： Wang Z,Ying C,Zhang A,Xu H,Jiang Y,Lou M

更新日期：2020-06-26 00:00:00

abstract：:Transfer of Bomirski amelanotic melanoma cells from in vivo to in vitro growth conditions results in occurrence of rapid melanization in their cytoplasm. The melanized cells from primary cell culture initiate tumours in hamsters, which do not contain traces of melanin and resemble typical amelanotic melanoma. ...

journal_title：Bioscience reports

authors： Słomiński A

更新日期：1983-02-01 00:00:00

abstract：:In a study of Necturus gallbladder epithelium Benzel et al. (Benzel et al., 1980) found that low (0.2-1.2 microM) and higher concentrations (1.5 microM and more) of cytochalasin B (CB) caused an increase and decrease in the transepithelial electrical resistance (TER), respectively. Moreover, there were slight changes ...

journal_title：Bioscience reports

authors： Nybom P,Magnusson KE

更新日期：1996-08-01 00:00:00

abstract：:Background: Many epidemiologic studies have explored the association between age at last birth (ALB) and the risk of epithelial ovarian cancer, but the results remain controversial. Methods: A literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and WanFang Med Onli...

journal_title：Bioscience reports

authors： Wu Y,Sun W,Xin X,Wang W,Zhang D

更新日期：2019-09-13 00:00:00

abstract：:This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...

journal_title：Bioscience reports

authors： Zaidi M

更新日期：1990-12-01 00:00:00

abstract：:Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...

journal_title：Bioscience reports

authors： Thompson MG,Pascal M,Mackie SC,Thom A,Morrison KS,Backwell FR,Palmer RM

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. METHODS:The robust rank aggregation method was used to mine differentially expressed genes...

journal_title：Bioscience reports

authors： Song Y,Tang W,Li H

更新日期：2021-01-29 00:00:00

abstract：:The first demonstration of a method to incorporate radiolabeled methyl groups from [14C]formaldehyde into membrane proteins in human erythrocytes by reductive methylation in the presence of NaCNBH3 is described. This method is based on the work of Jentoft and Dearborn [(1979) J. Biol. Chem. 254, 4359-4365], who demons...

journal_title：Bioscience reports

authors： Butterfield DA,Shahabuddin M

更新日期：1982-04-01 00:00:00

abstract：:Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...

journal_title：Bioscience reports

authors： Parsegian VA,Bezrukov SM,Vodyanoy I

更新日期：1995-12-01 00:00:00

abstract：:Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...

journal_title：Bioscience reports

authors： Alarcon C,Valverde I,Malaisse WJ

更新日期：1985-07-01 00:00:00

abstract：:Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific end...

journal_title：Bioscience reports

authors： Zhang M,Wu C

更新日期：2020-10-30 00:00:00

abstract：:Peanut (Arachis hypogaea) seed lectin, PNA is widely used to identify tumor specific antigen (T-antigen), Galbeta1-3GalNAc on the eukaryotic cell surface. The functional amino acid coding region of a cDNA clone, pBSH-PN was PCR amplified and cloned downstream of the polyhedrin promoter in the Autographa californica nu...

journal_title：Bioscience reports

authors： Kumar M,Behera AK,Kumar S,Srinivas VR,Das HR,Surolia A,Das RH

更新日期：1999-06-01 00:00:00

abstract：:Amphiphilic anionic peptides have been used to enhance the efficiency of transfection by helping plasmids to escape from endosomes to the cytosol. It has been shown that efficiency of an eicosamers containing five glutamyl residues (E5), can be considerably enhanced either by transforming it into a dimer or by adding ...

journal_title：Bioscience reports

authors： Freulon I,Monsigny M,Midoux P,Mayer R

更新日期：2000-10-01 00:00:00

abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

journal_title：Bioscience reports

authors： Hu P,Chen X,Sun J,Bie P,Zhang LD

更新日期：2015-01-14 00:00:00

abstract：:Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...

journal_title：Bioscience reports

authors： Chen X,He Y,Xu A,Deng Z,Feng J,Lu F,Yuan Y

更新日期：2019-02-26 00:00:00

abstract：:Chromosome 14 ORF 166 (C14orf166), a protein involved in the regulation of RNA transcription and translation, has been reported to possess the potency to promote tumorigenesis; however, the role of C14orf166 in non-small-cell lung cancer (NSCLC) remains unknown. The purpose of the present study was to assess C14orf166...

journal_title：Bioscience reports

authors： Zhou YW,Li R,Duan CJ,Gao Y,Cheng YD,Zhang CF

更新日期：2018-09-13 00:00:00

abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...

journal_title：Bioscience reports

authors： Odedra BR,Palmer TN

更新日期：1981-02-01 00:00:00

abstract：:Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...

journal_title：Bioscience reports

authors： Zhou L,Xiao X

更新日期：2018-04-13 00:00:00

abstract：:Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...

journal_title：Bioscience reports

authors： Liu X,Gao H,Zhang J,Xue D

更新日期：2019-05-07 00:00:00

abstract：:Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diagnosis and treatment...

journal_title：Bioscience reports

authors： Li H,He J,Yi H,Xiang G,Chen K,Fu B,Yang Y,Chen G

更新日期：2015-03-18 00:00:00

abstract：:Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. After salt fractionation and reconstitution the major portion of SLI was purified by gel filtration and two HPLC steps; in all three systems it eluted in the positio...

journal_title：Bioscience reports

authors： Corder R,Sykes JE,Lowry PJ

更新日期：1982-03-01 00:00:00

abstract：:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...

journal_title：Bioscience reports

authors： Weiss AKH,Naschberger A,Cappuccio E,Metzger C,Mottes L,Holzknecht M,von Velsen J,Bowler MW,Rupp B,Jansen-Dürr P

更新日期：2020-03-27 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) act as crucial modulators during the development of diverse cancers. Although various types of lncRNAs in prostate cancer (PCa) have been explored, quantities of lncRNAs still wait to be exploited. The present study is to probe the functions and mechanism of lncRNA HOXA cluster antisense...

journal_title：Bioscience reports

authors： Xiao S,Song B

更新日期：2020-08-28 00:00:00