The role of gut microbiota in the effects of maternal obesity during pregnancy on offspring metabolism.

abstract：:Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa. In the present study, we investigated the possible role of a novel autoph...

journal_title：Bioscience reports

authors： Liu J,Chen Z,Guo J,Wang L,Liu X

更新日期：2019-08-23 00:00:00

abstract：:The first demonstration of a method to incorporate radiolabeled methyl groups from [14C]formaldehyde into membrane proteins in human erythrocytes by reductive methylation in the presence of NaCNBH3 is described. This method is based on the work of Jentoft and Dearborn [(1979) J. Biol. Chem. 254, 4359-4365], who demons...

journal_title：Bioscience reports

authors： Butterfield DA,Shahabuddin M

更新日期：1982-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been frequently identified as key mediators in almost all developmental and pathological processes, including those in the liver. The present study was conducted with aims of investigating the role of microRNA-138 (miR-138) in acute liver failure (ALF) via a mechanism involving p53 and liver ma...

journal_title：Bioscience reports

authors： Wang YQ,Lan YY,Guo YC,Yuan QW,Liu P

更新日期：2019-07-18 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for G protein alpha-subunits and are thought to be responsible for rapid deactivation of G protein mediated signaling pathway. In this present study, we demonstrate that PA is the most efficient candidate to inhibit GAP activity of RG...

journal_title：Bioscience reports

authors： Ou-Yang YS,Tu Y,Yang F

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:The role of lncRNAs in tumor has been widely concerned. The present study took HAS2-AS1 (the antisense RNA 1 of HAS2) as a starting point to explore its expression in glioma and its role in the process of migration and invasion, providing a strong theoretical basis for mining potential therapeutic targets of ...

journal_title：Bioscience reports

authors： Wang J,Gu J,You A,Li J,Zhang Y,Rao G,Ge X,Zhang K,Li J,Liu X,Wang Q,Lin T,Cheng L,Zhu M,Wu X,Wang D

更新日期：2020-08-28 00:00:00

abstract：:The kinetics of the fusion process between erythrocyte ghosts, as induced by Sendai virus, were readily revealed by a simple fluorescence procedure previously employed to characterize the fusion of viruses with biological membranes. The method relies on the relief of fluorescence selfquenching of the membrane-inserted...

journal_title：Bioscience reports

authors： Hoekstra D,Klappe K

更新日期：1986-11-01 00:00:00

abstract：:Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...

journal_title：Bioscience reports

authors： Pi L,Fu L,Xu Y,Che D,Deng Q,Huang X,Li M,Zhang L,Huang P,Gu X

更新日期：2018-05-22 00:00:00

abstract：:Native bovine parathyroid hormone (bPTH) was found to be readily cleaved with human leukocyte elastase to yield the fragments bPTH(1-41) and bPTH(42-84). These were then isolated by reverse-phase HPLC and characterised by gas-phase sequencing and amino acid analysis. The biological activities of these fragments were a...

journal_title：Bioscience reports

authors： Barling PM,Lowe C

更新日期：1987-01-01 00:00:00

abstract：:Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...

journal_title：Bioscience reports

authors： Franchi J,Marteau C,Crola da Silva C,Mitterrand M,André P,Kieda C

更新日期：2008-02-01 00:00:00

abstract：:Antimicrobial peptides are a promising resource for developing novel antibiotic and even anticancer drugs. Here, a 28-mer polypeptide, Ranatuerin-2PLx (R2PLx), was identified from lyophilised skin secretions. The chemically synthetic replicates exhibited moderate and broadspectrum antimicrobial effect against various ...

journal_title：Bioscience reports

authors： Chen X,Zhang L,Ma C,Zhang Y,Xi X,Wang L,Zhou M,Burrows JF,Chen T

更新日期：2018-11-09 00:00:00

abstract：:An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...

journal_title：Bioscience reports

authors： Shanker G,Pieringer RA

更新日期：1985-07-01 00:00:00

abstract：:To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PB...

journal_title：Bioscience reports

authors： Li N,Zhu L,Zhou H,Zheng D,Xu G,Sun L,Gao J,Shao G

更新日期：2020-11-27 00:00:00

abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...

journal_title：Bioscience reports

authors： de Sousa FD,da Silva BB,Furtado GP,Carneiro IS,Lobo MDP,Guan Y,Guo J,Coker AR,Lourenzoni MR,Guedes MIF,Owen JS,Abraham DJ,Monteiro-Moreira ACO,Moreira RA

更新日期：2017-07-21 00:00:00

abstract：:Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological...

journal_title：Bioscience reports

authors： Huiskonen JT

更新日期：2018-04-27 00:00:00

abstract：:Radioactivity from [14C] adenosine was linearly incorporated into tissue nucleotides in perfused rat hearts. All the TCA-extractable 14C was confined to the purine nucleoside phosphates for up to 1 h of perfusion. Radioactivity was also incorporated linearly into the TCA-insoluble fraction, which by 40 min accounted f...

journal_title：Bioscience reports

authors： Hutchinson WL,Bates DJ,Perrett D,Mowbray J

更新日期：1981-11-01 00:00:00

abstract：:Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels...

journal_title：Bioscience reports

authors： Wang W,Shi Y,Li J,Cui W,Yang B

更新日期：2016-04-05 00:00:00

abstract：:Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a signifi...

journal_title：Bioscience reports

authors： Rothwell NJ,Saville ME,Stock MJ

更新日期：1984-04-01 00:00:00

abstract：:The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...

journal_title：Bioscience reports

authors： Pochmann D,Innocente AM,Cotomacci G,Barreto-Chaves ML,Sarkis JJ

更新日期：2008-10-01 00:00:00

abstract：:Fungal endophytes are known to secrete a large array of secondary metabolites (phenols, flavonoids, indole acetic acid (IAA) etc.) that facilitate crops under stress conditions. Considering this, a potent plant growth promoting endophyte (SXSp1) from the spines and leaves of Solanum xanthocarpum L. has been isolated. ...

journal_title：Bioscience reports

authors： Jan FG,Hamayun M,Hussain A,Iqbal A,Jan G,Khan SA,Khan H,Lee IJ

更新日期：2019-10-30 00:00:00

abstract：:Fatty-acid synthesis has been measured in vivo with 3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also ...

journal_title：Bioscience reports

authors： Rothwell NJ,Stock MJ,Trayhurn P

更新日期：1983-03-01 00:00:00

abstract：:Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...

journal_title：Bioscience reports

authors： Huang Y,Fan G,Yang F

更新日期：1994-08-01 00:00:00

abstract：:Cilia and flagella are critical organelles with conserved internal structures and diverse developmental and physiological processes according to cell type. Although the core components of structures are shared with thousands of associated proteins involved in cilia or flagella formation, we hypothesized that some unkn...

journal_title：Bioscience reports

authors： Li ZZ,Zhao WL,Wang GS,Gu NH,Sun F

更新日期：2020-01-31 00:00:00

abstract：:Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...

journal_title：Bioscience reports

authors： Liu P,Zhuo Z,Li W,Cheng J,Zhou H,He J,Zhang J,Wang J

更新日期：2019-01-22 00:00:00

abstract：:Coagulation factor IX (FIX) is an essential plasma protein for blood coagulation. The first epidermal growth factor (EGF) motif of FIX (EGF-F9) has been reported to attenuate cell adhesion to the extracellular matrix (ECM). The purpose of the present study was to determine the effects of this motif on cell adhesion an...

journal_title：Bioscience reports

authors： Ishikawa T,Kitano H,Mamiya A,Kokubun S,Hidai C

更新日期：2016-06-03 00:00:00

abstract：:The nucleotide sequence of the thioredoxin gene from Escherichia coli was determined. The structural gene was identified on a cloned 3-kb PvuII fragment by hybridization with a synthetic oligodeoxyribonucleotide corresponding to a part of the amino acid sequence of thioredoxin. Restriction-enzyme fragments were used a...

journal_title：Bioscience reports

authors： Höög JO,von Bahr-Lindström H,Josephson S,Wallace BJ,Kushner SR,Jörnvall H,Holmgren A

更新日期：1984-11-01 00:00:00

abstract：:In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integr...

journal_title：Bioscience reports

authors： Spinazzola A,Zeviani M

更新日期：2007-06-01 00:00:00

abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...

journal_title：Bioscience reports

authors： Kim J,Barsoum IB,Loh H,Paré JF,Siemens DR,Graham CH

更新日期：2020-01-31 00:00:00

abstract：:The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...

journal_title：Bioscience reports

authors： Jencks WP

更新日期：1995-10-01 00:00:00

abstract：:Leishmaniasis is a group of infectious and non-contagious severe parasitic diseases, caused by protozoans of the Leishmania genus. Natural products characterize a rich source of prospective chemical entities for the development of new effective drugs for neglected diseases. Scientific evaluation of medicinal plants ha...

journal_title：Bioscience reports

authors： Almayouf MA,El-Khadragy MF,Awad MA,Al-Olayan EM

更新日期：2020-11-30 00:00:00

abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...

journal_title：Bioscience reports

authors： Odedra BR,Palmer TN

更新日期：1981-02-01 00:00:00