Abstract:
:The neurotransmitter, serotonin has emerged as a tumor growth factor and immune response regulator through complex signaling pathways. Yip1 Interacting Factor Homolog B (YIF1B) is a membrane protein involved in serotonin receptor (HTR) membrane trafficking and signal transmission in neuropathy. Participation of YIF1B in serotonin-induced tumor growth and immune regulation has not been previously investigated. Data for analysis of YIF1B mRNA expression were downloaded from the website portals: The Cancer Genome Atlas (TCGA), GTEx, Cancer Cell Line Encyclopedia (CCLE) and International Cancer Genome Consortium (ICGC), including clinical and mutational information. Survival analysis included the Kaplan-Meier method for calculation of the cumulative incidence of the survival event and the log rank method for comparison of survival curves between groups. Infiltration levels of immune cells were calculated and correlated with YIF1B expression using the Spearman correlation test to evaluate significance. Further correlation analyses between YIF1B expression and mutation indicators such as tumor mutation burden (TMB), microsatellite instability (MSI), and mismatch repair (MMR) were also examined by the Spearman test. YIF1B expression was elevated in most cancer types and this high expression was indicative of poor overall survival (OS) and death-specific survival. In breast invasive carcinoma (BRCA) and liver hepatocellular carcinoma (LIHC), high YIF1B expression correlated with a poor disease-free interval (DFI), indicating a role in malignancy progression. There was a positive relationship between YIF1B expression and immune cell infiltration in several cancer types, and YIF1B also positively correlated with TMB, MSI, and methylation in some cancer types, linking its expression to possible evaluation of therapy response. The bioinformatics analyses have, therefore, established YIF1B as a good biomarker for prognostic and therapeutic evaluation.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Liu J,Chen Z,Zhao P,Li Wdoi
10.1042/BSR20201384subject
Has Abstractpub_date
2020-07-31 00:00:00issue
7eissn
0144-8463issn
1573-4935pii
225759journal_volume
40pub_type
杂志文章abstract::The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01199053
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202391
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114933
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150034
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 临床试验,杂志文章
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journal_title:Bioscience reports
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pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114868
更新日期:1981-04-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201082
更新日期:2020-06-26 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01198464
更新日期:1996-12-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121639
更新日期:1988-10-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202346
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117344
更新日期:1988-12-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192666
更新日期:2020-01-31 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180876
更新日期:2018-11-20 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01122123
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116468
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doi:10.1042/BSR20160135
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170289
更新日期:2017-06-21 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116998
更新日期:1985-08-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01120697
更新日期:1983-06-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181538
更新日期:2019-01-11 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180568
更新日期:2018-06-27 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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abstract::Increasing studies are indicating that long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been disputed. Therefore, we aimed to further explore the prognostic value and clinical significance of XIST in various types of cance...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析,评审
doi:10.1042/BSR20180169
更新日期:2018-06-21 00:00:00