Abstract:
:Brain cells dissociated from 15-day-old embryonic mice and grown in culture contain both cytosolic and nuclear receptors for L-3,5,3'-triiodothyronine (L-T3). KD values for L-T3 of 3.05 X 10(-9) M and 4.2 X 10(-9) M were determined with the cytosolic and nuclear receptors respectively. These cultured cells, which are suitable for studying the regulation of myelination by T3 in vitro, display a high specificity for L-T3 in that the receptors for L-T3 do not bind D-T3, D-thyroxine, L-diiodothyronine, or DL-thyronine, and bind only small amounts of L-thyroxine.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Shanker G,Bhat NR,Pieringer RAdoi
10.1007/BF01114868subject
Has Abstractpub_date
1981-04-01 00:00:00pages
289-97issue
4eissn
0144-8463issn
1573-4935journal_volume
1pub_type
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