Mammalian cells contain a DNA-recombining activity that can be dissociated from topoisomerase activity.

abstract：:Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...

journal_title：Bioscience reports

authors： Liu J,Tang T,Wang GD,Liu B

更新日期：2019-07-15 00:00:00

abstract：:The purpose of the study is to investigate the correlation between the expression of C-reactive protein (CRP) and autophagy-related 9B (ATG9B) and pathological features of clear cell renal cell carcinoma (CCRCC) patients. We also intended to explore the effects of manipulated expression of CRP and ATG9B on the apoptos...

journal_title：Bioscience reports

authors： Ma Z,Qi Z,Shan Z,Li J,Yang J,Xu Z

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...

journal_title：Bioscience reports

authors： Li Y,Wang X,Zhao Z,Shang J,Li G,Zhang R

更新日期：2021-01-04 00:00:00

abstract：:PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1+/- mice, Sirt1 mRNA expression was not changed but Sirt1 protein ...

journal_title：Bioscience reports

authors： Liu Q,Zhang Y,Yang S,Wu Y,Wang J,Yu W,Liu Y

更新日期：2017-12-12 00:00:00

abstract：:Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a screening method for RBC vesicle shedding using the Ca(2+) ionophore...

journal_title：Bioscience reports

authors： Kostova EB,Beuger BM,Klei TR,Halonen P,Lieftink C,Beijersbergen R,van den Berg TK,van Bruggen R

更新日期：2015-04-16 00:00:00

abstract：:To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and ...

journal_title：Bioscience reports

authors： He K,Qu H,Xu LN,Gao J,Cheng FY,Xiang P,Zhou CQ

更新日期：2016-09-16 00:00:00

abstract：:The extracts of Paulownia tomentosa (P. tomentosa) exhibit multiple pharmacological activities. In the present study, P. tomentosa flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated i...

journal_title：Bioscience reports

authors： Yang H,Zhang P,Xu X,Chen X,Liu Q,Jiang C

更新日期：2019-05-03 00:00:00

abstract：:Esophageal cancer is seen with increasing incidence, but the underlying mechanism of esophageal cancer is still unknown. Transient receptor potential melastatin (TRPM) is non-selective cation channels. It has been verified that TRPM channels play crucial roles in development and progression of multiple tumors. Increas...

journal_title：Bioscience reports

authors： Lan X,Zhao J,Song C,Yuan Q,Liu X

更新日期：2019-10-30 00:00:00

abstract：:MicroRNA-326 (miR-326) was reported to be dysregulated and involved in the progression of multiple cancers. However, the clinical significance, biological role and underlying mechanism of miR-326 in the carcinogenesis of breast cancer are still unclear. In the present study, we showed that miR-326 was down-regulated i...

journal_title：Bioscience reports

authors： Du Y,Shen L,Zhang W,Ding R,Li Q,Li S,Zhang H

更新日期：2019-07-29 00:00:00

abstract：:Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...

journal_title：Bioscience reports

authors： Han HF,Chen Q,Zhao WW

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. MATERIALS AND METHODS:The data used in this research were collected from Google Scholar, Web of Science, CNKI, and ...

journal_title：Bioscience reports

authors： Wang BJ,Chen JY,Guan Y,Liu DC,Cao ZC,Kong J,Wu ZS,Wu WY

更新日期：2021-01-27 00:00:00

abstract：:Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...

journal_title：Bioscience reports

authors： Imai A,Matsunami K,Iida K,Tamaya T

更新日期：1990-02-01 00:00:00

abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...

journal_title：Bioscience reports

authors： Pierrat OA,Paudyal A,Woodruff J,Koroleva O,Boateng SY

更新日期：2017-07-07 00:00:00

abstract：:Capacity to synthesize glucose, urea, and ketone bodies is well maintained in hepatocytes after storage for at least 24 h at 4 degrees C. Substrates and albumin are the only requirements. ...

journal_title：Bioscience reports

authors： Farrell R,Lund P

更新日期：1983-06-01 00:00:00

abstract：:Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...

journal_title：Bioscience reports

authors： Peng C,Zou X,Xia W,Gao H,Li Z,Liu N,Xu Z,Gao C,He Z,Niu W,Fang R,Biswas S,Agrez M,Zhi X,Niu J

更新日期：2018-12-07 00:00:00

abstract：:Incubation of adult rat cardiac myocytes with increasing glucose concentrations decreased phosphorylation (αThr172) and activity of AMPK (AMP-activated protein kinase). The effect could be demonstrated without measurable changes in adenine nucleotide contents. The glucose effect was additive to the decrease in AMPK ac...

journal_title：Bioscience reports

authors： Tabidi I,Saggerson D

更新日期：2012-06-01 00:00:00

abstract：:Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the uncoupling protein yielded five positive clones, pUCPr...

journal_title：Bioscience reports

authors： Ridley RG,Patel HV,Parfett CL,Olynyk KA,Reichling S,Freeman KB

更新日期：1986-01-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) act as crucial modulators during the development of diverse cancers. Although various types of lncRNAs in prostate cancer (PCa) have been explored, quantities of lncRNAs still wait to be exploited. The present study is to probe the functions and mechanism of lncRNA HOXA cluster antisense...

journal_title：Bioscience reports

authors： Xiao S,Song B

更新日期：2020-08-28 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature ...

journal_title：Bioscience reports

authors： Feng X,Li L,Wang L,Luo S,Bai X

更新日期：2019-04-16 00:00:00

abstract：:Huaier Granule, a type of traditional Chinese biomedical preparation (TCBP), is considered to be a promising adjuvant therapy for breast cancer. Although an analysis of the published literature has been performed, the exact effects and safety of Huaier Granule remains controversial. Therefore, a wide-ranging systemati...

journal_title：Bioscience reports

authors： Yao X,Wu W,Qu K,Xi W

更新日期：2020-08-28 00:00:00

abstract：:Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determi...

journal_title：Bioscience reports

authors： Yaqinuddin A,Abbas F,Naqvi SZ,Bashir MU,Qazi R,Qureshi SA

更新日期：2008-12-01 00:00:00

abstract：:Chagas disease remains a serious health problem for countries where the most common mode of transmission is infection contracted from the feces of a Triatominae insect vector. In México, 32 species of Triatoma have been identified; amongst them, Triatoma (Meccus) pallidipennis is an endemic species reported to have hi...

journal_title：Bioscience reports

authors： Díaz-Garrido P,Sepúlveda-Robles O,Martínez-Martínez I,Espinoza B

更新日期：2018-09-28 00:00:00

abstract：:HF (heart failure) after MI (myocardial infarction) is a major cause of morbidity and mortality worldwide. Recent studies have shown that hydrogen sulfide (H2S) has cardioprotective effects. Hence, we aimed to elucidate the potential effects of H2S on HF after MI in rats. The HF model after MI was made by ligating the...

journal_title：Bioscience reports

authors： Wang X,Wang Q,Guo W,Zhu YZ

更新日期：2011-04-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms (SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed b...

journal_title：Bioscience reports

authors： Zhou X,Liao F,Zhang J,Qin Y,Xu H,Ding Z,Zhang Y,Zhang F

更新日期：2018-06-27 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia ...

journal_title：Bioscience reports

authors： Akter S,Jahan I,Khatun MR,Khan MF,Arshad L,Jakaria M,Haque MA

更新日期：2021-01-29 00:00:00

abstract：:High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of th...

journal_title：Bioscience reports

authors： Weikel KA,Cacicedo JM,Ruderman NB,Ido Y

更新日期：2016-09-16 00:00:00

abstract：:Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...

journal_title：Bioscience reports

authors： Zhao Y,Fang S,Que K,Xu G,Zhang H,Qi C,Yang N

更新日期：2018-12-07 00:00:00

abstract：:The nucleotide sequence of the thioredoxin gene from Escherichia coli was determined. The structural gene was identified on a cloned 3-kb PvuII fragment by hybridization with a synthetic oligodeoxyribonucleotide corresponding to a part of the amino acid sequence of thioredoxin. Restriction-enzyme fragments were used a...

journal_title：Bioscience reports

authors： Höög JO,von Bahr-Lindström H,Josephson S,Wallace BJ,Kushner SR,Jörnvall H,Holmgren A

更新日期：1984-11-01 00:00:00

abstract：:Fanconi Anemia (FA) is a rare genetic disorder characterized by developmental defects, bone marrow failure and high predisposition to cancer. The FA DNA repair pathway is required in humans to coordinate repair of DNA interstrand cross-links. The central event in the activation of the pathway is the monoubiquitination...

journal_title：Bioscience reports

authors： Frost MG,Mazloumi Aboukheili AM,Toth R,Walden H

更新日期：2020-06-26 00:00:00