Predicted the P2RX7rs3751143 Polymorphism Is Associated with Cancer Risk:A Meta-Analysis and Systematic Review.

abstract：:Chemical transformations, like osmotic translocations, are transport processes when looked at in detail. In chemiosmotic systems, the pathways of specific ligand conduction are spatially orientated through osmoenzymes and porters in which the actions of chemical group, electron and solute transfer occur as vectorial (...

journal_title：Bioscience reports

authors： Mitchell PD

更新日期：2004-08-01 00:00:00

abstract：RATIONALE:Houshiheisan (HSHS), a classic prescription in traditional Chinese medicine (TCM), has remarkable efficacy in the treatment of ischemic stroke. OBJECTIVE:To investigate the pro-angiogenic effect and molecular mechanism of HSHS for stroke recovery. METHODS AND RESULTS:The rat permanent middle cerebral artery...

journal_title：Bioscience reports

authors： Xiang Y,Yao X,Wang X,Zhao H,Zou H,Wang L,Zhang QX

更新日期：2019-10-30 00:00:00

abstract：:A new method for detecting viral antibodies in cerebrospinal fluid is described. The technique has many advantages over previously published methods in that it is highly sensitive eliminating the need to concentrate the CSF, takes 5 h to complete, avoids the use of radionucleides, and most importantly circumvents prob...

journal_title：Bioscience reports

authors： Moyle S,Keir G,Thompson EJ

更新日期：1984-06-01 00:00:00

abstract：:The present study was designed to investigate the protective effect of moracin on primary culture of nucleus pulposus cells in intervertebral disc and explore the underlying mechanism. Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1β, IL-6 and TNF-α) in nucleus pulpos...

journal_title：Bioscience reports

authors： Gu R,Huang Z,Liu H,Qing Q,Zhuan Z,Yang L,Su Z,Huang W

更新日期：2019-12-20 00:00:00

abstract：:Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...

journal_title：Bioscience reports

authors： Krasnov GS,Puzanov GA,Afanasyeva MA,Dashinimaev EB,Vishnyakova KS,Beniaminov AD,Adzhubei AA,Kondratieva TT,Yegorov YE,Senchenko VN

更新日期：2019-12-20 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...

journal_title：Bioscience reports

authors： Barciszewska AM

更新日期：2018-10-22 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cell...

journal_title：Bioscience reports

authors： Diao X,Yang D,Chen Y,Liu W

更新日期：2019-04-09 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA), play a unique role in modulating the apoptotic threshold in cells. The mechanism is thought to involve, in part, inhibition of translocation for Bax from the cytosol to mitochondria. Here, we attempted to use the native fluoresce...

journal_title：Bioscience reports

authors： Zhang W,Steer CJ,Douglas KT,Rodrigues CM

更新日期：2006-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection can cause inflammatory tissue-invasive end-organ diseases upon lytic replication. In humans, mature miR-200b-3p and -200c-3p suppress the synthesis of HCMV immediate early 2 (IE2) protein by binding to the 3'-UTR of the mRNA encoded by the unique long (UL) 122-123 region in human...

journal_title：Bioscience reports

authors： Lee KH,Lim BJ,Ferreira VH,Min SY,Hong YM,Jo JH,Han SH

更新日期：2018-12-07 00:00:00

abstract：:Ehrlich Ascites Tumour cells were irradiated with UV-light to crosslink DNA to proteins in vivo. The DNA fragments associated with the nuclear lamina were purified and characterized. The results of the Cot analysis and the hybridization experiments suggest that the DNA fragments attached to the nuclear lamina although...

journal_title：Bioscience reports

authors： Christova R,Yaneva J,Galcheva-Gargova Z

更新日期：1989-10-01 00:00:00

abstract：:We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...

journal_title：Bioscience reports

authors： Jablonski G,Klem KH,Danielsen CC,Mosekilde L,Gordeladze JO

更新日期：1996-02-01 00:00:00

abstract：:Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast c...

journal_title：Bioscience reports

authors： Wu H,Wang Y,Chen T,Li Y,Wang H,Zhang L,Chen S,Wang W,Yang Q,Chen C

更新日期：2018-10-17 00:00:00

abstract：:Ca-ATPase activity in sarcoplasmic reticulum (SR) membranes isolated from skeletal muscles of the typical hibernator, the ground squirrel Spermophilus undulatus, is about 2-fold lower than that in SR membranes of rats and rabbits and is further decreased 2-fold during hibernation. The use of carbocyanine anionic dye S...

journal_title：Bioscience reports

authors： Malysheva AN,Storey KB,Lopina OD,Rubtsov AM

更新日期：2001-12-01 00:00:00

abstract：:In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...

journal_title：Bioscience reports

authors： Schwarting GA,Gajewski A

更新日期：1988-08-01 00:00:00

abstract：:Chagas disease remains a serious health problem for countries where the most common mode of transmission is infection contracted from the feces of a Triatominae insect vector. In México, 32 species of Triatoma have been identified; amongst them, Triatoma (Meccus) pallidipennis is an endemic species reported to have hi...

journal_title：Bioscience reports

authors： Díaz-Garrido P,Sepúlveda-Robles O,Martínez-Martínez I,Espinoza B

更新日期：2018-09-28 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...

journal_title：Bioscience reports

authors： Webster JA,Yang Z,Kim YH,Loo D,Mosa RM,Li H,Chen C

更新日期：2017-05-17 00:00:00

abstract：:The purpose of the study is to investigate the correlation between the expression of C-reactive protein (CRP) and autophagy-related 9B (ATG9B) and pathological features of clear cell renal cell carcinoma (CCRCC) patients. We also intended to explore the effects of manipulated expression of CRP and ATG9B on the apoptos...

journal_title：Bioscience reports

authors： Ma Z,Qi Z,Shan Z,Li J,Yang J,Xu Z

更新日期：2017-11-15 00:00:00

abstract：:Mitochondrial genome is a powerful molecule marker to provide information for phylogenetic relationships and revealing molecular evolution in ichthyological studies. Sebastiscus species, a marine rockfish, are of essential economic value. However, the taxonomic status and phylogenetic relationships of Sebastidae have ...

journal_title：Bioscience reports

authors： Jia C,Zhang X,Xu S,Yang T,Yanagimoto T,Gao T

更新日期：2020-12-23 00:00:00

abstract：:One of the major obstacles to obtaining human cells of a defined and reproducible standard suitable for use as medical therapies is the necessity for FCS (fetal calf serum) media augmentation in routine cell culture applications. FCS has become the supplement of choice for cell culture research, as it contains an arra...

journal_title：Bioscience reports

authors： Bryan N,Andrews KD,Loughran MJ,Rhodes NP,Hunt JA

更新日期：2011-06-01 00:00:00

abstract：:The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT(4a) and h5-HT(4b) receptors. In the present study, the internalization of these two splice variants following receptor stimulation was investigated with confocal ...

journal_title：Bioscience reports

authors： Pindon A,Van Hecke G,Josson K,Van Gompel P,Lesage A,Leysen JE,Jurzak M

更新日期：2004-06-01 00:00:00

abstract：:miR-155 has multiple functions in many physiological and pathological processes. However, little is known about the expression characteristics of avian miR-155. In the present study, partial pri-miR-155 sequences were cloned from AA+ broiler, Sanhuang broiler and Hy-Line Brown layer, respectively. Stem-loop qRT-PCR wa...

journal_title：Bioscience reports

authors： Xu S,Chang Y,Wu G,Zhang W,Man C

更新日期：2020-06-26 00:00:00

abstract：:Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...

journal_title：Bioscience reports

authors： Wang J,Ni J,Song D,Ding M,Huang J,Li W,He G

更新日期：2020-06-26 00:00:00

abstract：:The affinity of epigallocatechin gallate (EGCG) for human serum albumin (HSA) was measured in physiological conditions using NMR and isothermal titration calorimetry (ITC). NMR estimated the Ka (self-dissociation constant) of EGCG as 50 mM. NMR showed two binding events: strong (n1=1.8 ± 0.2; Kd1 =19 ± 12 μM) and weak...

journal_title：Bioscience reports

authors： Eaton JD,Williamson MP

更新日期：2017-05-11 00:00:00

abstract：:A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...

journal_title：Bioscience reports

authors： Merritt JE,Dobson PR,Wojcikiewicz RJ,Baird JG,Brown BL

更新日期：1984-12-01 00:00:00

abstract：:Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...

journal_title：Bioscience reports

authors： Liu Z,Jin X,Pi W,Liu S

更新日期：2017-12-05 00:00:00

abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...

journal_title：Bioscience reports

authors： Connelly LW,Keller RK

更新日期：1984-09-01 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00