Abstract:
:A new method for detecting viral antibodies in cerebrospinal fluid is described. The technique has many advantages over previously published methods in that it is highly sensitive eliminating the need to concentrate the CSF, takes 5 h to complete, avoids the use of radionucleides, and most importantly circumvents problems associated with prozone effects which occur in immunoprecipitation reaction since the viral antigen is immobilized on nitrocellulose membranes.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Moyle S,Keir G,Thompson EJdoi
10.1007/BF01122226subject
Has Abstractpub_date
1984-06-01 00:00:00pages
505-10issue
6eissn
0144-8463issn
1573-4935journal_volume
4pub_type
杂志文章abstract::Accumulating evidence demonstrates that long non-coding RNAs (LncRNAs) play important roles in regulating gene expression and are involved in various cancers, including colorectal cancer (CRC). However, LncRNA profiles in CRC remain largely unknown. The present study aims to find the key LncRNA associated with CRC and...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160048
更新日期:2016-05-06 00:00:00
abstract::Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114811
更新日期:1989-12-01 00:00:00
abstract::This short article provides a comment on the recent article by Tauriainen et al. [Bioscience Reports (2018) 38, BSR20171274 https://doi.org/10.1042/BSR20171274]. ...
journal_title:Bioscience reports
pub_type: 评论,信件
doi:10.1042/BSR20180505
更新日期:2018-10-31 00:00:00
abstract::The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116191
更新日期:1981-05-01 00:00:00
abstract::Superoxide dismutase (SOD), a metal containing enzyme is present in parasite Leishmania donovani as well as in host macrophages both resident and activated in a detectable amount, although the level is much higher in the latter case. It is observed that at any particular protein concentration, the SOD activity is high...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116457
更新日期:1988-04-01 00:00:00
abstract::In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191835
更新日期:2019-11-29 00:00:00
abstract::Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181277
更新日期:2019-01-18 00:00:00
abstract::Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170105
更新日期:2017-05-17 00:00:00
abstract::Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200784
更新日期:2020-09-30 00:00:00
abstract::The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190083
更新日期:2019-04-02 00:00:00
abstract::Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201285
更新日期:2020-12-23 00:00:00
abstract::Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion pr...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1010454803579
更新日期:2000-12-01 00:00:00
abstract::Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193845
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:MicroRNA-135 (miR-135) is a well-known non-coding RNA that has been demonstrated to participate in tumorigenesis and cancer development; however, the clinical prognostic value of miR-135 in digestive system cancers remains controversial. This meta-analysis aims to explore the potential value of miR-135 as a ...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20190845
更新日期:2019-12-20 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181746
更新日期:2019-05-31 00:00:00
abstract::The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160265
更新日期:2017-01-17 00:00:00
abstract::miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170899
更新日期:2017-12-05 00:00:00
abstract::Brain metastases are the most common intracranial tumors in adults. They usually originate from: lung, breast, renal cell and gastrointestinal cancers, as well as melanoma. Prognosis for brain metastases is still poor and classical treatment combining surgery and radiation therapy should be strongly supported with mol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180731
更新日期:2018-10-22 00:00:00
abstract::We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs s...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20130018
更新日期:2013-05-24 00:00:00
abstract:BACKGROUND:Breast cancer (BC) is the most common malignancy among females worldwide. The tumor microenvironment usually prevents effective lymphocyte activation and infiltration, and suppresses infiltrating effector cells, leading to a failure of the host to reject the tumor. CC chemokines play a significant role in in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202042
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND/AIMS:MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. METHODS:The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, a...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191908
更新日期:2020-06-26 00:00:00
abstract::The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active subst...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01128815
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:Our aim was to investigate the effect of emodin on intestinal and lung injury induced by acute intestinal injury in rats and explore potential molecular mechanisms. METHODS:Healthy male Sprague-Dawley (SD) rats were randomly divided into five groups (n=10, each group): normal group; saline group; acute intes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201605
更新日期:2020-09-30 00:00:00
abstract::The identification of the sodium potassium pump as a Na+, K+ -ATPase is described. ...
journal_title:Bioscience reports
pub_type: 传,历史文章
doi:10.1023/a:1020196612909
更新日期:1998-08-01 00:00:00
abstract::Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20190377
更新日期:2019-08-02 00:00:00
abstract::Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190304
更新日期:2019-07-08 00:00:00
abstract::Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20180323
更新日期:2018-08-29 00:00:00
abstract:AIM:IgA nephropathy (IgAN) is one of the most common chronic glomerulonephritis. Its etiology and pathogenesis remain unclear. We thus explored the immune repertoire of the B-cell receptor (BCR) and the heavy-chain complementarity-determining region 3 (CDR3) in renal tissue and peripheral blood of IgAN patients. METHO...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190482
更新日期:2019-10-30 00:00:00
abstract::Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114972
更新日期:1986-11-01 00:00:00
abstract::Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01200247
更新日期:1994-08-01 00:00:00