miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis.

abstract：:In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...

journal_title：Bioscience reports

authors： Sun H,Zhang J,Ma Y,Liu J

更新日期：2020-09-30 00:00:00

abstract：:Phagocytosis by neutrophils, macrophages, and other professional phagocytes requires rapid remodeling of actin. Early phagosomes are surrounded by a rim of F-actin that is disassembled during phagosomoal maturation. Breakdown of periphagosomal F-actin and phagolysosome fusion are calcium dependent processes in neutrop...

journal_title：Bioscience reports

authors： Tejle K,Magnusson KE,Rasmusson B

更新日期：2002-10-01 00:00:00

abstract：:High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...

journal_title：Bioscience reports

authors： Holm J,Hansen SI,Høier-Madsen M

更新日期：1991-06-01 00:00:00

abstract：:Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...

journal_title：Bioscience reports

authors： Li B,Yuan Z,Jiang J,Rao Y

更新日期：2018-12-11 00:00:00

abstract：:To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and f...

journal_title：Bioscience reports

authors： Gong L,Tang Y,Jiang L,Tang W,Luo S

更新日期：2020-12-23 00:00:00

abstract：:Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diagnosis and treatment...

journal_title：Bioscience reports

authors： Li H,He J,Yi H,Xiang G,Chen K,Fu B,Yang Y,Chen G

更新日期：2015-03-18 00:00:00

abstract：:Three myoid-cell clones were established from the thymuses of two Wistar rats; one thymus yielded two clones, R615A and R615B2, and the other yielded one clone, R613Ad. The three clones were divided into two subtypes. Both subtypes were able to form myofibrils, expressed AChR on their cell-surface membrane, and contai...

journal_title：Bioscience reports

authors： Kamo I,Nonaka I,Furukawa S,Satoyoshi E

更新日期：1984-11-01 00:00:00

abstract：:The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...

journal_title：Bioscience reports

authors： Pochmann D,Innocente AM,Cotomacci G,Barreto-Chaves ML,Sarkis JJ

更新日期：2008-10-01 00:00:00

abstract：:Gram negative bacterial infection is a leading cause of fatality and is attributed, at least in part, to the bacteria's capacity to persist in the host in spite of appropriate antibiotic therapy. It has been suggested that bacteria evade antibiotics by hiding within host cells. We sought to investigate this important ...

journal_title：Bioscience reports

authors： Shin JS,Gao Z,Abraham SN

更新日期：1999-10-01 00:00:00

abstract：:Whole-genome analyses become more and more necessary for pharmaceutical research. DNA chip hybridizations are an important tool for monitoring gene expression profiles during diseases or medical treatment. However, drug target identification and validation as well as an increasing number of antibodies and other polype...

journal_title：Bioscience reports

authors： Maercker C

更新日期：2005-02-01 00:00:00

abstract：:Blood platelets have the capacity to participate in a number of physiological as well as pathological processes within the circulation. In order to evaluate their cellular reactivity a number of platelet function tests have been developed. The main in vitro function tests are assessment of aggregation and adhesion, se...

journal_title：Bioscience reports

authors： Spangenberg P,Till U

更新日期：1989-06-01 00:00:00

abstract：:Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...

journal_title：Bioscience reports

authors： Cherubin P,Guyette J,Taylor M,O'Donnell M,Herndon L,Burress H,Riad A,Tatulian SA,Teter K

更新日期：2018-09-07 00:00:00

abstract：:Muscle tissue levels of d1-alpha-tocopherol (vitamin E) were significantly lower in endurance-trained rats than in sedentary animals, whether the animals were fed on vitamin-E-deficient or control (vitamin-E-sufficient) diets. In vitamin-E-deficient rats, liver tissue levels of vitamin E were significantly lower in th...

journal_title：Bioscience reports

authors： Aikawa KM,Quintanilha AT,de Lumen BO,Brooks GA,Packer L

更新日期：1984-03-01 00:00:00

abstract：:The effect of ligands (glucose, ATP and Mg2+) and zwitterionic micelles of lysophosphatidylcholine (LPC) or N-hexadecyl-N,N-dimethyl-3-ammonium propanesulfonate (HPS) in the yeast hexokinase (HK) stability was studied at 35 degrees C. The thermal inactivation kinetics followed one-exponential decay. The effect of liga...

journal_title：Bioscience reports

authors： Guerra R,Bianconi ML

更新日期：2000-02-01 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:The physiological role of an alternative oxidase and an uncoupling protein in plant and protists is discussed in terms of thermogenesis and energy metabolism balance in the cell. It is concluded that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitocho...

journal_title：Bioscience reports

authors： Jarmuszkiewicz W,Sluse-Goffart CM,Vercesi AE,Sluse FE

更新日期：2001-04-01 00:00:00

abstract：:Heparin causes lysis of the multilamellar liposomes of all three charges, positive, neutral, and negative, and thus releases the entrapped [3H]glucose or chromate. The lytic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with ...

journal_title：Bioscience reports

authors： Patel HM,Parvez N,Field J,Ryman BE

更新日期：1983-01-01 00:00:00

abstract：:In the present study, we investigated the role of lncRNA SAMMSON in hepatocellular carcinoma (HCC). We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. miR-9-3p was down-regulated in HCC tiss...

journal_title：Bioscience reports

authors： Yang S,Cai H,Hu B,Tu J

更新日期：2019-07-05 00:00:00

abstract：:Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1-3-oligosaccharides. Maximal oligosaccharide-glucosidase activity was obtained at pH 6.2 and a detergent concentration of 0.5% Triton X-100. This activity could be distinguished from non-specific alpha-glucosidase acti...

journal_title：Bioscience reports

authors： Hettkamp H,Bause E,Legler G

更新日期：1982-11-01 00:00:00

abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...

journal_title：Bioscience reports

authors： Pierrat OA,Paudyal A,Woodruff J,Koroleva O,Boateng SY

更新日期：2017-07-07 00:00:00

abstract：:Western blotting was used as a powerful alternative to immunoprecipitation for the detection of the simian virus 40 (SV40) large tumor (T) antigen. After resolution by electrophoresis on a SDS-polyacrylamide gel of a [35S]methionine labeled crude extract from SV40 infected monkey kidney cells, the separated proteins w...

journal_title：Bioscience reports

authors： Dietrich JB

更新日期：1985-02-01 00:00:00

abstract：:A model explaining quantal Ca2+ release as an intrinsic property of the inositol 1,4,5-triphosphate (IP3) receptor has been put forward. The model is based on the hypothesis that the IP3 receptor can catalyze a transformation of the IP3 molecule differing from its conventional metabolism. A simple kinetic mechanism is...

journal_title：Bioscience reports

authors： Kaimachnikov NP,Nazarenko VG

更新日期：1996-10-01 00:00:00

abstract：:Clustered Regularly Interspaced Short Palindromic Repeat activation-synergistic activation mediator system (CRISPRa-SAM) has been efficiently used to up-regulate the targeted genes in human and mouse. But it is not known whether the CRISPRa-SAM system can be used against porcine disease because its two important trans...

journal_title：Bioscience reports

authors： Jiang J,Sun Y,Xiao R,Wai K,Ahmad MJ,Khan FA,Zhou H,Li Z,Zhang Y,Zhou A,Zhang S

更新日期：2019-08-19 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...

journal_title：Bioscience reports

authors： Yao Y,Zhang T,Qi L,Liu R,Liu G,Wang J,Song Q,Sun C

更新日期：2020-01-31 00:00:00

abstract：:This is the first report of its kind that well demonstrates that a lectin from Phytolacca americana [Pa-2 (P. americana lectin-2)] can also be intrinsically unordered, based on the results obtained by CD, tryptophan fluorescence, ANS (8-anilinonaphthalene-1-sulfonic acid) binding, acrylamide quenching, DLS (dynamic li...

journal_title：Bioscience reports

authors： Ahmad E,Kamranur Rahman S,Masood Khan J,Varshney A,Hasan Khan R

更新日期：2009-11-23 00:00:00

abstract：:Brain cells dissociated from 15-day-old embryonic mice and grown in culture contain both cytosolic and nuclear receptors for L-3,5,3'-triiodothyronine (L-T3). KD values for L-T3 of 3.05 X 10(-9) M and 4.2 X 10(-9) M were determined with the cytosolic and nuclear receptors respectively. These cultured cells, which are ...

journal_title：Bioscience reports

authors： Shanker G,Bhat NR,Pieringer RA

更新日期：1981-04-01 00:00:00

abstract：:Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...

journal_title：Bioscience reports

authors： Webster JA,Yang Z,Kim YH,Loo D,Mosa RM,Li H,Chen C

更新日期：2017-05-17 00:00:00

abstract：:Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

journal_title：Bioscience reports

authors： Zhao H,Liu M,Liu H,Suo R,Lu C

更新日期：2020-03-27 00:00:00

abstract：:Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...

journal_title：Bioscience reports

authors： Sim E,Palmer MS,Puklavec M,Sim RB

更新日期：1983-12-01 00:00:00

abstract：:One of the major obstacles to obtaining human cells of a defined and reproducible standard suitable for use as medical therapies is the necessity for FCS (fetal calf serum) media augmentation in routine cell culture applications. FCS has become the supplement of choice for cell culture research, as it contains an arra...

journal_title：Bioscience reports

authors： Bryan N,Andrews KD,Loughran MJ,Rhodes NP,Hunt JA

更新日期：2011-06-01 00:00:00