TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma.

abstract：:Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in ca...

journal_title：Bioscience reports

authors： Ding B,Lou W,Xu L,Fan W

更新日期：2018-10-09 00:00:00

abstract：:Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

journal_title：Bioscience reports

authors： Tian S,Xing YN,Xia P

更新日期：2018-10-31 00:00:00

abstract：:Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...

journal_title：Bioscience reports

authors： Malhotra R,Haurum J,Thiel S,Jensenius JC,Sim RB

更新日期：1993-04-01 00:00:00

abstract：:An increase in the permeability of outer mitochondrial membrane is central to apoptotic cell death, and results in the release of several apoptogenic factors such as cytochrome c into the cytoplasm to activate downstream destructive programs. The voltage-dependent anion channel (VDAC or mitochondrial porin) plays an e...

journal_title：Bioscience reports

authors： Tsujimoto Y

更新日期：2002-02-01 00:00:00

abstract：:This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...

journal_title：Bioscience reports

authors： Zaidi M

更新日期：1990-12-01 00:00:00

abstract：:Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se Large numbers of human and animal studies have demonstrated that the gut microbiota plays a pivotal role in ...

journal_title：Bioscience reports

authors： Zhou L,Xiao X

更新日期：2018-04-13 00:00:00

abstract：:The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter...

journal_title：Bioscience reports

authors： Kelly JM,Goddard JP

更新日期：1981-05-01 00:00:00

abstract：:Chemical transformations, like osmotic translocations, are transport processes when looked at in detail. In chemiosmotic systems, the pathways of specific ligand conduction are spatially orientated through osmoenzymes and porters in which the actions of chemical group, electron and solute transfer occur as vectorial (...

journal_title：Bioscience reports

authors： Mitchell PD

更新日期：2004-08-01 00:00:00

abstract：:Having a better grasp of the molecular mechanisms underlying carcinogenesis and progression in osteosarcoma would be helpful to find novel therapeutic targets. Different types of cancers have presented abnormal expression of miRNA-101 (miR-101). Nevertheless, we still could not figure out what expression of miR-101 in...

journal_title：Bioscience reports

authors： Lin H,Zheng X,Lu T,Gu Y,Zheng C,Yan H

更新日期：2019-02-08 00:00:00

abstract：:Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...

journal_title：Bioscience reports

authors： Wu J,Pan W,Wang C,Dong H,Xing L,Hou J,Fang S,Li H,Yang F,Yu B

更新日期：2019-07-08 00:00:00

abstract：:Diabetic neuropathy (DNP) is the most common complication of diabetes mellitus affecting approximately 50% of diabetes patients. Studying the effect of potential drugs with antioxidant properties and minimal toxicities on neural cells may lead to the development of new and safe pharmacotherapy. Dexmedetomidine (DEX), ...

journal_title：Bioscience reports

authors： Hou X,Xu F,Zhang C,Shuai J,Huang Z,Liang Y,Xu X

更新日期：2020-06-26 00:00:00

abstract：:The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...

journal_title：Bioscience reports

authors： Xie XJ,Fan DM,Xi K,Chen YW,Qi PW,Li QH,Fang L,Ma LG

更新日期：2017-06-27 00:00:00

abstract：:The nucleotide sequence of the thioredoxin gene from Escherichia coli was determined. The structural gene was identified on a cloned 3-kb PvuII fragment by hybridization with a synthetic oligodeoxyribonucleotide corresponding to a part of the amino acid sequence of thioredoxin. Restriction-enzyme fragments were used a...

journal_title：Bioscience reports

authors： Höög JO,von Bahr-Lindström H,Josephson S,Wallace BJ,Kushner SR,Jörnvall H,Holmgren A

更新日期：1984-11-01 00:00:00

abstract：:Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...

journal_title：Bioscience reports

authors： Li B,Yuan Z,Jiang J,Rao Y

更新日期：2018-12-11 00:00:00

abstract：:Evidence is presented in support of a pathway in skeletal muscle of glyconeogenesis (glycogen biosynthesis de novo) from L-glutamate and related amino acids involving the enzyme phosphoenolpyruvate carboxykinase (PEP CK). In the rat hemidiaphragm in vitro, not only did L-[U]-14C]glutamate exert a glycogen-sparing acti...

journal_title：Bioscience reports

authors： Odedra BR,Palmer TN

更新日期：1981-02-01 00:00:00

abstract：:Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus--a tissue culture-adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insu...

journal_title：Bioscience reports

authors： Szopa TM,Gamble DR,Taylor KW

更新日期：1985-01-01 00:00:00

abstract：:The extracts of Paulownia tomentosa (P. tomentosa) exhibit multiple pharmacological activities. In the present study, P. tomentosa flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated i...

journal_title：Bioscience reports

authors： Yang H,Zhang P,Xu X,Chen X,Liu Q,Jiang C

更新日期：2019-05-03 00:00:00

abstract：:Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...

journal_title：Bioscience reports

authors： Liu P,Zhuo Z,Li W,Cheng J,Zhou H,He J,Zhang J,Wang J

更新日期：2019-01-22 00:00:00

abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...

journal_title：Bioscience reports

authors： de Sousa FD,da Silva BB,Furtado GP,Carneiro IS,Lobo MDP,Guan Y,Guo J,Coker AR,Lourenzoni MR,Guedes MIF,Owen JS,Abraham DJ,Monteiro-Moreira ACO,Moreira RA

更新日期：2017-07-21 00:00:00

abstract：:In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...

journal_title：Bioscience reports

authors： Liu S,Li Y,Xu H,Wang K,Li N,Li J,Sun T,Xu Y

更新日期：2016-06-30 00:00:00

abstract：:The sarcolemma of smooth-muscle cells from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 microU/ml or 10 pM)....

journal_title：Bioscience reports

authors： Popescu LM,Nutu O,Panoiu C

更新日期：1985-01-01 00:00:00

abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...

journal_title：Bioscience reports

authors： Wenger SL,Senft JR,Sargent LM,Bamezai R,Bairwa N,Grant SG

更新日期：2004-12-01 00:00:00

abstract：:Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

journal_title：Bioscience reports

authors： Zhao H,Liu M,Liu H,Suo R,Lu C

更新日期：2020-03-27 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...

journal_title：Bioscience reports

authors： Ma Y,Chen SS,Feng YY,Wang HL

更新日期：2020-09-30 00:00:00

abstract：:Ehrlich Ascites Tumour cells were irradiated with UV-light to crosslink DNA to proteins in vivo. The DNA fragments associated with the nuclear lamina were purified and characterized. The results of the Cot analysis and the hybridization experiments suggest that the DNA fragments attached to the nuclear lamina although...

journal_title：Bioscience reports

authors： Christova R,Yaneva J,Galcheva-Gargova Z

更新日期：1989-10-01 00:00:00

abstract：:The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...

journal_title：Bioscience reports

authors： Jencks WP

更新日期：1995-10-01 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：:The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...

journal_title：Bioscience reports

authors： Gomperts BD,Cockcroft S,Howell TW,Nüsse O,Tatham PE

更新日期：1987-05-01 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00

abstract：:Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...

journal_title：Bioscience reports

authors： Cherubin P,Guyette J,Taylor M,O'Donnell M,Herndon L,Burress H,Riad A,Tatulian SA,Teter K

更新日期：2018-09-07 00:00:00