Abstract：
:Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation in activin receptor-like kinase 2 (ALK2), a bone morphogenetic protein (BMP) type I receptor. Initial studies show that mutant ALK2 drives HO by constitutively activating the BMP signaling pathway. Recently, mutant ALK2 has been shown to transduce Smad1/5 signaling and enhance chondrogenesis, calcification in response to Activin A, which normally signals through Smad2/3 and inhibits BMP signaling pathway. Furthermore, Activin A induces heterotopic bone formation via mutant ALK2, while inhibition of Activin A blocks spontaneous and trauma-induced HO. In this manuscript, we describe the molecular mechanism of the causative gene ALK2 in FOP, mainly focusing on the prominent role of Activin A in HO. It reveals a potential strategy for prevention and treatment of FOP by inhibition of Activin A. Further studies are needed to explore the cellular and molecular mechanisms of Activin A in FOP in more detail.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Lin H,Shi F,Gao J,Hua Pdoi
10.1042/BSR20190377subject
Has Abstractpub_date
2019-08-02 00:00:00issue
8eissn
0144-8463issn
1573-4935pii
BSR20190377journal_volume
39pub_type
杂志文章,评审abstract：:Bladder cancer is a common malignant tumour worldwide. Epithelial-mesenchymal transition (EMT)-related biomarkers can be used for early diagnosis and prognosis of cancer patients. To explore, accurate prediction models are essential to the diagnosis and treatment for bladder cancer. In the present study, an EMT-relate...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203944
更新日期：2021-01-29 00:00:00
abstract：:A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201083
更新日期：2020-07-31 00:00:00
abstract：BACKGROUND:Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. MATERIALS AND METHODS:The data used in this research were collected from Google Scholar, Web of Science, CNKI, and ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193877
更新日期：2021-01-27 00:00:00
abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201199
更新日期：2020-06-26 00:00:00
abstract：:Gram negative bacterial infection is a leading cause of fatality and is attributed, at least in part, to the bacteria's capacity to persist in the host in spite of appropriate antibiotic therapy. It has been suggested that bacteria evade antibiotics by hiding within host cells. We sought to investigate this important ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1020216323271
更新日期：1999-10-01 00:00:00
abstract：:The nature of certain forms of memory is discussed in relation to neural networks and REM sleep. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117331
更新日期：1988-12-01 00:00:00
abstract：:The kinetics of the fusion process between erythrocyte ghosts, as induced by Sendai virus, were readily revealed by a simple fluorescence procedure previously employed to characterize the fusion of viruses with biological membranes. The method relies on the relief of fluorescence selfquenching of the membrane-inserted...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114971
更新日期：1986-11-01 00:00:00
abstract：:The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT(4a) and h5-HT(4b) receptors. In the present study, the internalization of these two splice variants following receptor stimulation was investigated with confocal ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/s10540-005-2582-5
更新日期：2004-06-01 00:00:00
abstract：:Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues and cell lines compared with adjacent normal colorectal tissues...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190884
更新日期：2019-08-13 00:00:00
abstract：:Disc nucleus pulposus (NP) cell experiences periodic osmolarity alterations during daily activities, which has been proved to affect cell biology in vitro The present study was aimed to investigate the effects of cartilage-derived morphogenetic protein-2 (CDMP-2) on NP cell apoptosis under the hyperosmolarity culture ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181176
更新日期：2018-10-09 00:00:00
abstract：:Sendai virus envelopes (SVE) were isolated from Sendai virus particles by Triton X-100 solubilization and ultracentrifugation. The envelopes were reconstituted in the presence of the fluorescent dye calcein by gradual removal of the detergent with Bio-beads SM-2. The internal volume of reconstituted Sendai virus envel...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01121911
更新日期：1984-07-01 00:00:00
abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20140124
更新日期：2015-01-14 00:00:00
abstract：:Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01122130
更新日期：1987-12-01 00:00:00
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journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01119661
更新日期：1984-03-01 00:00:00
abstract：:Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201232
更新日期：2020-06-26 00:00:00
abstract：BACKGROUND/AIMS:MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. METHODS:The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, a...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191908
更新日期：2020-06-26 00:00:00
abstract：:Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181635
更新日期：2019-05-14 00:00:00
abstract：:Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA), play a unique role in modulating the apoptotic threshold in cells. The mechanism is thought to involve, in part, inhibition of translocation for Bax from the cytosol to mitochondria. Here, we attempted to use the native fluoresce...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/s10540-006-9019-7
更新日期：2006-06-01 00:00:00
abstract：:Having a better grasp of the molecular mechanisms underlying carcinogenesis and progression in osteosarcoma would be helpful to find novel therapeutic targets. Different types of cancers have presented abnormal expression of miRNA-101 (miR-101). Nevertheless, we still could not figure out what expression of miR-101 in...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181283
更新日期：2019-02-08 00:00:00
abstract：:Reactive oxygen species (ROS) overproduction and renal tubular epithelial cell (TEC) apoptosis are key mechanisms of contrast-induced acute kidney injury (CI-AKI). Mitochondria are the main source of intracellular ROS. In the present study, the characteristics of mitophagy and the effects of rapamycin on contrast-indu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180876
更新日期：2018-11-20 00:00:00
abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170707
更新日期：2017-07-07 00:00:00
abstract：:We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs s...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20130018
更新日期：2013-05-24 00:00:00
abstract：:Mitochondrial genome is a powerful molecule marker to provide information for phylogenetic relationships and revealing molecular evolution in ichthyological studies. Sebastiscus species, a marine rockfish, are of essential economic value. However, the taxonomic status and phylogenetic relationships of Sebastidae have ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20203379
更新日期：2020-12-23 00:00:00
abstract：:An adenosine 3'5'-cyclic-monophosphate (Cyclic AMP)-dependent protein kinase has been identified and partially purified from the rat prostate tumor induced by 20-methylcholanthrene. This enzyme is stimulated 2- to 3-fold by the nucleotide. Equilibrium studies at pH 5.0 suggest the presence of a major class of binding ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114829
更新日期：1982-09-01 00:00:00
abstract：:Two established cancer cell lines, MCF-7 and Ishikawa, were both obtained directly from a cell repository and through another laboratory. The karyotypes from the two MCF-7 cell lines had up to 83 chromosomes and similarities for chromosomal gain and structural abnormalities. The two Ishikawa cell lines had up to 60 ch...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/s10540-005-2797-5
更新日期：2004-12-01 00:00:00
abstract：:Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193094
更新日期：2019-12-20 00:00:00
abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180854
更新日期：2018-11-09 00:00:00
abstract：:Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181693
更新日期：2018-12-11 00:00:00
abstract：:The human DEK proto-oncogene has been found to play an important role in autoimmune disease, viral infection and human carcinogenesis. Although it is transcriptionally up-regulated in cervical cancer, its intracellular function and regulation is still unexplored. In the present study, DEK and IκBα [inhibitor of NF-κB ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20100141
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20182458
更新日期：2020-04-30 00:00:00
