Abstract：
:Although membrane fusion occurs ubiquitously and continuously in all eukaroytic cells, little is known about the mechanism that governs lipid bilayer fusion associated with any intracellular fusion reactions. Recent studies of the fusion of enveloped viruses with host cell membranes have helped to define the fusion process. The identification and characterization of key proteins involved in fusion reactions have mainly driven recent advances in our understanding of membrane fusion. The most important denominator among the fusion proteins is the fusion peptide. In this review, work done in the last few years on the molecular mechanism of viral membrane fusion will be highlighted, focusing in particular on the role of the fusion peptide and the modification of the lipid bilayer structure. Much of what is known regarding the molecular mechanism of viral membrane fusion has been gained using liposomes as model systems in which the molecular components of the membrane and the environment are strictly controlled. Many amphilphilic peptides have a high affinity for lipid bilayers, but only a few sequences are able to induce membrane fusion. The presence of alpha-helical structure in at least part of the fusion peptide is strongly correlated with activity whereas, beta-structure tends to be less prevalent, associated with non-native experimental conditions, and more related to vesicle aggregation than fusion. The specific angle of insertion of the peptides into the membrane plane is also found to be an important characteristic for the fusion process. A shallow penetration, extending only to the central aliphatic core region, is likely responsible for the destabilization of the lipids required for coalescence of the apposing membranes and fusion.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Martin I,Ruysschaert JMdoi
10.1023/a:1010454803579keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
483-500issue
6eissn
0144-8463issn
1573-4935journal_volume
20pub_type
杂志文章,评审abstract：:The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116191
更新日期：1981-05-01 00:00:00
abstract：:The human DEK proto-oncogene has been found to play an important role in autoimmune disease, viral infection and human carcinogenesis. Although it is transcriptionally up-regulated in cervical cancer, its intracellular function and regulation is still unexplored. In the present study, DEK and IκBα [inhibitor of NF-κB ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20100141
更新日期：2012-06-01 00:00:00
abstract：:The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membran...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01119197
更新日期：1991-04-01 00:00:00
abstract：:Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114759
更新日期：1986-07-01 00:00:00
abstract：:Radioactivity from [14C] adenosine was linearly incorporated into tissue nucleotides in perfused rat hearts. All the TCA-extractable 14C was confined to the purine nucleoside phosphates for up to 1 h of perfusion. Radioactivity was also incorporated linearly into the TCA-insoluble fraction, which by 40 min accounted f...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114819
更新日期：1981-11-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymor...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191449
更新日期：2020-01-31 00:00:00
abstract：:Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its b...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20190126
更新日期：2019-05-10 00:00:00
abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...
journal_title：Bioscience reports
pub_type： 杂志文章,收录出版
doi：10.1042/BSR20171070
更新日期：2017-11-06 00:00:00
abstract：:A slow phase of linear exocytosis by fibroblasts of previously endocytosed fluid, succeeding the initial burst of release, is described. This is not due to cell lysis, is virtually abolished at 4 degrees C, and is retarded when the lysosomal system is expanded. It may reflect membrane recycling. ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01314215
更新日期：1982-08-01 00:00:00
abstract：:Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200067
更新日期：2020-05-29 00:00:00
abstract：BACKGROUND:This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. METHOD:A total of 225 Chinese Han patients with CRC were selected as the study group, and...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181074
更新日期：2019-01-15 00:00:00
abstract：:CYP (cytochrome P450) 3A29 in pigs could be an important candidate gene responsible for xenobiotic metabolism, similar to CYP3A4 in humans. Accordingly, the tissue expression of CYP3A29 mRNA in domestic pigs has been determined by a real-time PCR. The enzymatic properties of CYP3A29, CYP3A4 and PLM (pig liver microsom...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20100084
更新日期：2011-06-01 00:00:00
abstract：:Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01145960
更新日期：1993-04-01 00:00:00
abstract：:An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117073
更新日期：1985-07-01 00:00:00
abstract：:Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193845
更新日期：2020-02-28 00:00:00
abstract：:Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multip...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20201232
更新日期：2020-06-26 00:00:00
abstract：:Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20171667
更新日期：2018-02-08 00:00:00
abstract：:Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesized by processive glycosyltransferases from intracellular sugar nucleotide donors. Here we demonstrate that A...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20130053
更新日期：2013-09-04 00:00:00
abstract：:High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of th...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160174
更新日期：2016-09-16 00:00:00
abstract：:Micro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160035
更新日期：2016-06-03 00:00:00
abstract：:Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/qua...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192940
更新日期：2019-11-29 00:00:00
abstract：:Western blotting was used as a powerful alternative to immunoprecipitation for the detection of the simian virus 40 (SV40) large tumor (T) antigen. After resolution by electrophoresis on a SDS-polyacrylamide gel of a [35S]methionine labeled crude extract from SV40 infected monkey kidney cells, the separated proteins w...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117060
更新日期：1985-02-01 00:00:00
abstract：:A new method for detecting viral antibodies in cerebrospinal fluid is described. The technique has many advantages over previously published methods in that it is highly sensitive eliminating the need to concentrate the CSF, takes 5 h to complete, avoids the use of radionucleides, and most importantly circumvents prob...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01122226
更新日期：1984-06-01 00:00:00
abstract：:Intracellular lipid-binding proteins (iLBPs) of the fatty acid-binding protein (FABP) family of animals transport, mainly fatty acids or retinoids, are confined to the cytosol and have highly similar 3D structures. In contrast, nematodes possess fatty acid-binding proteins (nemFABPs) that are secreted into the perivit...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191292
更新日期：2019-07-23 00:00:00
abstract：:This review covers the recent progress in the elucidation of the structure of photosystem II (PSII). Because much of the structural information for this membrane protein complex has been revealed by electron microscopy (EM), the review will also consider the specific technical and interpretation problems that arise wi...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01206204
更新日期：1996-04-01 00:00:00
abstract：:Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expres...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181271
更新日期：2018-11-20 00:00:00
abstract：:Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181776
更新日期：2019-02-26 00:00:00
abstract：:More than 60 million people in the world have been diagnosed with HIV infections since the virus was recognized as the causative agent of AIDS in the 1980s. Even though more than half of the infected patients have died, effective disease treatment and prevention measures have not been established. ART (antiretroviral ...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20140097
更新日期：2014-08-18 00:00:00
abstract：:Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA), play a unique role in modulating the apoptotic threshold in cells. The mechanism is thought to involve, in part, inhibition of translocation for Bax from the cytosol to mitochondria. Here, we attempted to use the native fluoresce...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/s10540-006-9019-7
更新日期：2006-06-01 00:00:00
abstract：:Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01204353
更新日期：1995-12-01 00:00:00
