Abstract:
:The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membrane fluidity, occurred in a very short period of time. Lindane also provoked a number of changes in lipid biosynthesis from acetate in the membrane. Less [1-14C]acetate was incorporated into cholesterol and more into phospholipids when this liposoluble toxicant was added to the preincubation medium. However, not all phospholipid classes were equally increased, because while the rate of acetate incorporation was greater into choline glycerophospholipids than into ethanolamine glycerophospholipids, both were higher than the rates of acetate incorporation into serine glycerophospholipids and sphingomyelin.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Senar S,Gutierrez-Ocaña MT,Perez-Albarsanz MA,Recio MNdoi
10.1007/BF01119197subject
Has Abstractpub_date
1991-04-01 00:00:00pages
101-10issue
2eissn
0144-8463issn
1573-4935journal_volume
11pub_type
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