Influence of lindane on the fluidity of the rat ventral prostate membranes.

Abstract:

:The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membrane fluidity, occurred in a very short period of time. Lindane also provoked a number of changes in lipid biosynthesis from acetate in the membrane. Less [1-14C]acetate was incorporated into cholesterol and more into phospholipids when this liposoluble toxicant was added to the preincubation medium. However, not all phospholipid classes were equally increased, because while the rate of acetate incorporation was greater into choline glycerophospholipids than into ethanolamine glycerophospholipids, both were higher than the rates of acetate incorporation into serine glycerophospholipids and sphingomyelin.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Senar S,Gutierrez-Ocaña MT,Perez-Albarsanz MA,Recio MN

doi

10.1007/BF01119197

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

101-10

issue

2

eissn

0144-8463

issn

1573-4935

journal_volume

11

pub_type

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