Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.


:Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, we studied the role and mechanisms underlying periphery inflammation on brain tau transmission. By intraperitoneal injection of lipopolysaccharide (LPS) with brain medial entorhinal cortex (MEC)-specific overexpressing P301L human tau (P301L-hTau), we found that both acute and chronic administration of LPS remarkably promoted P301L-hTau transmission from MEC to the hippocampal subsets. Interestingly, the chronic LPS-induced P301L-hTau transmission was still apparent after blocking microglia activation. Further studies demonstrated that LPS disrupted the integrity of blood-brain barrier (BBB) and simultaneous intraperitoneal administration of glucocorticoid (GC) attenuated LPS-promoted P301L-hTau transmission. These data together suggest that a non-microglia-dependent BBB disruption contributes to peripheral LPS-promoted brain P301L-hTau transmission, therefore, maintaining the integrity of BBB can be a novel strategy for preventing pathological tau propagation in AD and other tauopathies.


Biosci Rep


Bioscience reports


Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ




Has Abstract


2020-02-28 00:00:00












  • Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11.

    abstract::Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

    更新日期:2019-07-25 00:00:00

  • Variants and expression changes in PPAR-encoding genes display no significant association with schizophrenia.

    abstract::A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li X,Zhu Y,Keaton M,Baranova A,Liu S,Hu X,Li Q,Cheng L,Zhou P,Cao H,Xu Y

    更新日期:2020-07-31 00:00:00

  • NMR studies of tumours.

    abstract::31p nuclear magnetic resonance (NMR) spectra have been obtained from animal and human tumours grown in laboratory rodents. The tumour cells are only slightly more acid than the surrounding muscle but they tend to have large Pi and sugar phosphate peaks, suggesting anoxia, and large but variable phosphodiester peaks. T...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Griffiths JR,Iles RA

    更新日期:1982-09-01 00:00:00

  • Prevalence and type distribution of human papillomavirus (HPV) in Malaysian women with and without cervical cancer: an updated estimate.

    abstract::Information on the prevalence and type distribution of human papillomavirus (HPV) among Malaysian women is currently limited. The present study therefore aimed to provide an updated estimate on the prevalence and type distribution of HPV among Malaysian women with and without cervical cancer. Total DNA was isolated fr...

    journal_title:Bioscience reports

    pub_type: 临床试验,杂志文章


    authors: Tan SC,Ismail MP,Duski DR,Othman NH,Ankathil R

    更新日期:2018-03-29 00:00:00

  • Solvation properties of ubiquinone-10 in solvents of different polarity.

    abstract::The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Ondarroa M,Sharma SK,Quinn PJ

    更新日期:1986-09-01 00:00:00

  • Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice.

    abstract::The large size of a 1.5-MDa ice-binding adhesin [MpAFP (Marinomonas primoryensis antifreeze protein)] from an Antarctic Gram-negative bacterium, M. primoryensis, is mainly due to its highly repetitive RII (Region II). MpAFP_RII contains roughly 120 tandem copies of an identical 104-residue repeat. We have previously d...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Vance TD,Olijve LL,Campbell RL,Voets IK,Davies PL,Guo S

    更新日期:2014-07-04 00:00:00

  • Tumor suppressor properties of the small C-terminal domain phosphatases in non-small cell lung cancer.

    abstract::Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Krasnov GS,Puzanov GA,Afanasyeva MA,Dashinimaev EB,Vishnyakova KS,Beniaminov AD,Adzhubei AA,Kondratieva TT,Yegorov YE,Senchenko VN

    更新日期:2019-12-20 00:00:00

  • miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease.

    abstract::To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PB...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li N,Zhu L,Zhou H,Zheng D,Xu G,Sun L,Gao J,Shao G

    更新日期:2020-11-27 00:00:00

  • Metabolomics study of fasudil on cisplatin-induced kidney injury.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Xia D,Lai X,Wu K,Zhou P,Li L,Guo Z,Xu S

    更新日期:2019-11-29 00:00:00

  • Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA-miRNA-mRNA networks and Cox regression models.

    abstract::Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...

    journal_title:Bioscience reports

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    authors: Yao Y,Zhang T,Qi L,Liu R,Liu G,Wang J,Song Q,Sun C

    更新日期:2020-01-31 00:00:00

  • Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Yaqinuddin A,Abbas F,Naqvi SZ,Bashir MU,Qazi R,Qureshi SA

    更新日期:2008-12-01 00:00:00

  • Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose-response meta-analysis.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wu G,Xue M,Zhao Y,Han Y,Zhang S,Zhang J,Li C,Xu J

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  • Diagnosis of nonsense mutations in Aspergillus nidulans.

    abstract::Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsens...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Martinelli SD,Roberts TJ

    更新日期:1983-01-01 00:00:00

  • Computational analysis and verification of molecular genetic targets for glioblastoma.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Xue L,Liu H,Chen Y,Wei L,Hong J

    更新日期:2020-06-26 00:00:00

  • Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhao L,Zheng YY,Chen Y,Ma YT,Yang YN,Li XM,Ma X,Xie X

    更新日期:2018-11-28 00:00:00

  • Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhu X,Yu H,Li B,Quan J,Zeng Z,Li G,Liu J

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  • Effect of a selective beta 2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Rothwell NJ,Stock MJ

    更新日期:1987-12-01 00:00:00

  • Rapamycin attenuates mitochondrial injury and renal tubular cell apoptosis in experimental contrast-induced acute kidney injury in rats.

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    pub_type: 杂志文章


    authors: Yang X,Yan X,Yang D,Zhou J,Song J,Yang D

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  • Chicken liver fatty acid synthetase dimer: evidence of asymmetrical structure from iodoacetamide inhibition studies.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Kumar S,Varagiannis E

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  • Immunochemical recognition of phosphate ester derivatives of phenol rings is dependent upon the electronic charge of the ester group.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jones JA,Wood A,Cushley W

    更新日期:1986-03-01 00:00:00

  • Effect of the beta-adrenoceptor agonist BRL 26830 on fatty acid synthesis and on the activities of pyruvate dehydrogenase and acetyl-CoA carboxylase in adipose tissues of the rat.

    abstract::BRL 26830 is a thermogenic beta-adrenoceptor agonist which stimulates lipolysis and fatty acid oxidation in vivo. It also stimulates insulin secretion, and hence promotes glucose utilisation in vivo. The effect of this agent on white and brown adipose tissue of the rat was investigated. BRL 26830 increased the rate of...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wilson S

    更新日期:1989-02-01 00:00:00

  • Ambra1 induces autophagy and desensitizes human prostate cancer cells to cisplatin.

    abstract::Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa. In the present study, we investigated the possible role of a novel autoph...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Liu J,Chen Z,Guo J,Wang L,Liu X

    更新日期:2019-08-23 00:00:00

  • A low-molecular-weight RNA species in yeast mitochondria arising from a 3' end trimming of cytochrome b pre-mRNA.

    abstract::Immobilization of yeast mitochondrial RNA on nitrocellulose filters without prior alkali treatment revealed a low-MW RNA species (integral of 300 bases) which hybridizes specifically to the RNA coding strand of a DNA fragment BglII-HinfI at the 3' end of the COB-BOX gene. This RNA species (often a doublet) was found i...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Halbreich A,Grandchamp C,Foucher M

    更新日期:1981-07-01 00:00:00

  • ∆Np73 is capable of inducing apoptosis by co-ordinately activating several BH3-only proteins.

    abstract::Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA. When p53 falls, other members of its family may become targets to attack tumoural cells. p73 has shown c...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Sánchez-Carrera D,García-Puga M,Yáñez L,Romón Í,Pipaón C

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  • OPN gene locus is associated with the risk of knee osteoarthritis: a case-control study.

    abstract:: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Shang H,Hao Y,Hu W,Hu X,Jin Q

    更新日期:2019-02-27 00:00:00

  • Multi-site binding of epigallocatechin gallate to human serum albumin measured by NMR and isothermal titration calorimetry.

    abstract::The affinity of epigallocatechin gallate (EGCG) for human serum albumin (HSA) was measured in physiological conditions using NMR and isothermal titration calorimetry (ITC). NMR estimated the Ka (self-dissociation constant) of EGCG as 50 mM. NMR showed two binding events: strong (n1=1.8 ± 0.2; Kd1 =19 ± 12 μM) and weak...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Eaton JD,Williamson MP

    更新日期:2017-05-11 00:00:00

  • Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high-magnitude compression though inhibiting the p38 MAPK pathway.

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    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Fang H,Li X,Shen H,Sun B,Teng H,Li P

    更新日期:2018-02-13 00:00:00

  • Glucose-induced reduction of the sodium content in beta-cell-rich pancreatic islets.

    abstract::The sodium contents of beta-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79-108 mmol sodium kg-1 dry weight. Exposure to glucose resu...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wesslén N,Bergsten P,Hellman B

    更新日期:1986-11-01 00:00:00

  • The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases.

    abstract::Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed that purified recombinant YjhC forms Neu5Ac from two dehydrated forms of this compound, 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-ac...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Kentache T,Thabault L,Peracchi A,Frédérick R,Bommer GT,Van Schaftingen E

    更新日期:2020-06-26 00:00:00

  • Silencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-κB p65.

    abstract::The human DEK proto-oncogene has been found to play an important role in autoimmune disease, viral infection and human carcinogenesis. Although it is transcriptionally up-regulated in cervical cancer, its intracellular function and regulation is still unexplored. In the present study, DEK and IκBα [inhibitor of NF-κB ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Liu K,Feng T,Liu J,Zhong M,Zhang S

    更新日期:2012-06-01 00:00:00