Abstract：
:Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through the selective barrier of the vascular ECs (endothelial cells). In the present study, we describe an in vitro model which takes into account the various steps of human skin inflammation, from keratinocyte activation to the adhesion of leucocytes to dermal capillary ECs. Human adult keratinocytes were subjected to stress by exposure to UV irradiation or neuropeptides, then the conditioned culture medium was used to mimic the natural micro-environmental conditions for dermal ECs. A relevant in vitro model must include appropriate cells from the skin. This is shown in the present study by the selective reaction of dermal ECs compared with EC lines from distinct origins, in terms of leucocyte recruitment, sensitivity to stress and nature of the stress-induced secreted mediators. This simplified model is suitable for the screening of anti-inflammatory molecules whose activity requires the presence of various skin cells.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Franchi J,Marteau C,Crola da Silva C,Mitterrand M,André P,Kieda Cdoi
10.1042/BSR20070012subject
Has Abstractpub_date
2008-02-01 00:00:00pages
23-32issue
1eissn
0144-8463issn
1573-4935pii
BSR20070012journal_volume
28pub_type
杂志文章abstract：:Since the Protein Data Bank (PDB) was founded in 1971, there are now over 120,000 depositions, the majority of which are from X-ray crystallography and 90% of those made use of synchrotron beamlines. At the Cambridge Structure Database (CSD), founded in 1965, there are more than 800,000 'small molecule' crystal struct...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20170204
更新日期：2017-07-04 00:00:00
abstract：:The purpose of the study is to investigate the correlation between the expression of C-reactive protein (CRP) and autophagy-related 9B (ATG9B) and pathological features of clear cell renal cell carcinoma (CCRCC) patients. We also intended to explore the effects of manipulated expression of CRP and ATG9B on the apoptos...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20171082
更新日期：2017-11-15 00:00:00
abstract：:Mice and rats are animals commonly used in research and laboratory testing. Compared with other animal species, they harbor many more zoonotic agents. Hymenolepis nana (H. nana) is a common tapeworm that parasitizes both humans and rodents. Although this tapeworm is of socio-economic importance worldwide, information ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20181224
更新日期：2019-02-08 00:00:00
abstract：:The physiological role of an alternative oxidase and an uncoupling protein in plant and protists is discussed in terms of thermogenesis and energy metabolism balance in the cell. It is concluded that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitocho...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1023/a:1013656510245
更新日期：2001-04-01 00:00:00
abstract：:Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/qua...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20192940
更新日期：2019-11-29 00:00:00
abstract：:Permeant cationic fluorescent probes are widely employed to monitor mitochondrial transmembrane potential and its changes. The application of such potential-dependent probes in conjunction with both fluorescence microscopy and fluorescence spectroscopy allows the monitoring of mitochondrial membrane potential in indiv...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/s10540-007-9033-4
更新日期：2007-06-01 00:00:00
abstract：:Leishmaniasis is a group of infectious and non-contagious severe parasitic diseases, caused by protozoans of the Leishmania genus. Natural products characterize a rich source of prospective chemical entities for the development of new effective drugs for neglected diseases. Scientific evaluation of medicinal plants ha...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20202672
更新日期：2020-11-30 00:00:00
abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170707
更新日期：2017-07-07 00:00:00
abstract：:The effects of E. coli endotoxin 0127 B8 on oxygen consumption, temperature, and on the activity of the proton conductance pathway in brown adipose tissue (BAT) were investigated in rats and mice. In rats an increase was observed in rectal and skin temperature, whole body oxygen consumption and GDP binding in BAT. In ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116509
更新日期：1987-06-01 00:00:00
abstract：:Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1023/a:1014768909442
更新日期：2001-10-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have reviewed association of CTGF in the development and progression ...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1042/BSR20191374
更新日期：2019-07-18 00:00:00
abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170301
更新日期：2017-07-27 00:00:00
abstract：:A consensus about the prognostic role of NIMA-related kinase 2 (NEK2) expression in various solid tumors has not been made yet. Thus, this meta-analysis aimed to systematically assess the prognostic role of NEK2 expression in patients with solid tumors. The eligible studies were identified through searching PubMed, We...
journal_title：Bioscience reports
pub_type： 杂志文章,meta分析
doi：10.1042/BSR20180618
更新日期：2019-01-18 00:00:00
abstract：:Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20180243
更新日期：2018-12-07 00:00:00
abstract：:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural simila...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20194431
更新日期：2020-03-27 00:00:00
abstract：BACKGROUND/AIMS:MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. METHODS:The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, a...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191908
更新日期：2020-06-26 00:00:00
abstract：:The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01117101
更新日期：1986-09-01 00:00:00
abstract：:The cellular onc-genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens, whereas muscle extracts show an age-dependent decrease in the amounts of c-src-...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01128817
更新日期：1984-09-01 00:00:00
abstract：:This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...
journal_title：Bioscience reports
pub_type： 杂志文章,评审
doi：10.1007/BF01788370
更新日期：1995-10-01 00:00:00
abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01128818
更新日期：1984-09-01 00:00:00
abstract：:Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170650
更新日期：2017-07-16 00:00:00
abstract：:Radioactivity from [14C] adenosine was linearly incorporated into tissue nucleotides in perfused rat hearts. All the TCA-extractable 14C was confined to the purine nucleoside phosphates for up to 1 h of perfusion. Radioactivity was also incorporated linearly into the TCA-insoluble fraction, which by 40 min accounted f...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01114819
更新日期：1981-11-01 00:00:00
abstract：:To explore the effect and mechanism of LncRNA LUCAT1 in cervical cancer (CC). In the present study, 67 cases of CC patients and 60 healthy cases were selected as the research objects. CC patients were selected as the study group (SG) and healthy physical examination patients were selected as the control group (CG). LU...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20200422
更新日期：2020-04-30 00:00:00
abstract：:Esophageal cancer is seen with increasing incidence, but the underlying mechanism of esophageal cancer is still unknown. Transient receptor potential melastatin (TRPM) is non-selective cation channels. It has been verified that TRPM channels play crucial roles in development and progression of multiple tumors. Increas...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191878
更新日期：2019-10-30 00:00:00
abstract：:A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1007/BF01116866
更新日期：1987-09-01 00:00:00
abstract：RATIONALE:Houshiheisan (HSHS), a classic prescription in traditional Chinese medicine (TCM), has remarkable efficacy in the treatment of ischemic stroke. OBJECTIVE:To investigate the pro-angiogenic effect and molecular mechanism of HSHS for stroke recovery. METHODS AND RESULTS:The rat permanent middle cerebral artery...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20191006
更新日期：2019-10-30 00:00:00
abstract：:Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20080158
更新日期：2009-10-06 00:00:00
abstract：:The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20170186
更新日期：2017-06-27 00:00:00
abstract：:miRNAs are non-coding RNA molecules typically 18-22 nucleotides long that can suppress the expression of their target genes. Several laboratories have attempted to identify miRNAs from the pig that are involved in Salmonella infection. These bioinformatics strategies using the newly available genomic sequence are gene...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20160243
更新日期：2016-08-31 00:00:00
abstract：:Erectile dysfunction (ED) is one of the significant complications of diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis and NO production in the vascular endothelium by activating PKC. The present study was aimed to investigate the efficacy of Leech and Centipede Granules (LCG) through ...
journal_title：Bioscience reports
pub_type： 杂志文章
doi：10.1042/BSR20193845
更新日期：2020-02-28 00:00:00
