Abstract:
:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to identify the clinical significance of TINCR in prognosis and malignant progression of hepatocellular carcinoma (HCC). TINCR expression in HCC specimens at various stages of tumorigenesis were measured by quantitative real-time RT PCR (qRT-PCR). The matched para-carcinoma tissues were used as controls. The associations of TINCR with clinicopathological characteristics, disease-free survival (DFS) and overall survival (OS) of patients were further evaluated. Results revealed that high TINCR expression was significantly correlated with tumor size (P=0.005), tumor differentiation status (P=0.017), TNM stage (P=0.010), and vascular invasion (P=0.004). Moreover, Kaplan-Meier analysis demonstrated that TINCR was correlated to both DFS and OS in HCC cohorts. Patients with high TINCR expression tended to have worse prognosis. Multivariate Cox regression analysis indicated that TINCR was an independent poor prognostic indicator for DFS (HR =1.32, 95% CI: 1.00-1.57, P=0.000) and OS (HR =1.57, 95% CI: 1.30-1.86, P=0.004) in HCC. TINCR was demonstrated as a direct target of miR-137 and miR-133a, and was suppressed by miR-137/miR-133a These results provide the first evidence that the expression of TINCR in HCC may play an oncogenic role in HCC differentiation, invasion, and metastasis. miR-137/miR-133a-TINCR pathway may serve as a promising target for tumor recurrence and prognosis of patients with HCC.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Tian F,Xu J,Xue F,Guan E,Xu Xdoi
10.1042/BSR20170301subject
Has Abstractpub_date
2017-07-27 00:00:00issue
4eissn
0144-8463issn
1573-4935pii
BSR20170301journal_volume
37pub_type
杂志文章abstract::This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116615
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abstract::In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...
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doi:10.1042/BSR20150034
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2848-y
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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doi:10.1042/BSR20160122
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journal_title:Bioscience reports
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doi:10.1007/BF01114972
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abstract::Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200858
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170209
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020182404940
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182200
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116383
更新日期:1982-03-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20100026
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
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