Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.

Abstract:

:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural similarity with human FAHD1, a rabbit monoclonal antibody (RabMab) could be produced that is able to recognize mouse FAHD1, but not the human form, whereas a polyclonal antibody recognized both proteins. Epitope mapping in combination with our deposited crystal structures revealed that the epitope overlaps with a reported SIRT3 deacetylation site in mouse FAHD1.

journal_name

Biosci Rep

journal_title

Bioscience reports

authors

Weiss AKH,Naschberger A,Cappuccio E,Metzger C,Mottes L,Holzknecht M,von Velsen J,Bowler MW,Rupp B,Jansen-Dürr P

doi

10.1042/BSR20194431

subject

Has Abstract

pub_date

2020-03-27 00:00:00

issue

3

eissn

0144-8463

issn

1573-4935

pii

222164

journal_volume

40

pub_type

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