Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.


:FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1. Despite high structural similarity with human FAHD1, a rabbit monoclonal antibody (RabMab) could be produced that is able to recognize mouse FAHD1, but not the human form, whereas a polyclonal antibody recognized both proteins. Epitope mapping in combination with our deposited crystal structures revealed that the epitope overlaps with a reported SIRT3 deacetylation site in mouse FAHD1.


Biosci Rep


Bioscience reports


Weiss AKH,Naschberger A,Cappuccio E,Metzger C,Mottes L,Holzknecht M,von Velsen J,Bowler MW,Rupp B,Jansen-Dürr P




Has Abstract


2020-03-27 00:00:00












  • Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) has a high recurrence rate and poor clinical outcome after currently used therapies, including radiofrequency ablation. To explore the possible mechanisms for the relapse of HCC, in the present study we focussed on long non-coding RNA (LncRNA), which has been reported to be involved in t...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhu X,Yu H,Li B,Quan J,Zeng Z,Li G,Liu J

    更新日期:2019-11-29 00:00:00

  • Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico.

    abstract::NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•-), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels, the NOX2 isoform has been consid...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Macías-Pérez ME,Martínez-Ramos F,Padilla-Martínez II,Correa-Basurto J,Kispert L,Mendieta-Wejebe JE,Rosales-Hernández MC

    更新日期:2013-08-02 00:00:00

  • Mechanism of liposome destabilization by polycationic amino acids.

    abstract::Polycationic amino acids induce the leakage and fusion of liposomes containing anionic lipids. We have investigated the nature and extent of the changes in membrane physical properties caused by these polypeptides which could result in the observed membrane destabilization. We found that in the range of pH 5 to pH 7 b...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Epand RM,Lim W

    更新日期:1995-06-01 00:00:00

  • The Effects of Silver Nanoparticles Biosynthesized Using Fig and Olive Extracts on Cutaneous leishmaniasis Induced Inflammation in Female Balb/c Mice.

    abstract::Leishmaniasis is a group of infectious and non-contagious severe parasitic diseases, caused by protozoans of the Leishmania genus. Natural products characterize a rich source of prospective chemical entities for the development of new effective drugs for neglected diseases. Scientific evaluation of medicinal plants ha...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Almayouf MA,El-Khadragy MF,Awad MA,Al-Olayan EM

    更新日期:2020-11-30 00:00:00

  • Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus.

    abstract::Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析


    authors: Zhao Y,Fang S,Que K,Xu G,Zhang H,Qi C,Yang N

    更新日期:2018-12-07 00:00:00

  • Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system.

    abstract::The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Song C,Kim N,Park M,Lee J,Oh KB,Sim T

    更新日期:2019-01-08 00:00:00

  • 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound.

    abstract::The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Sha HH,Wang Z,Dong SC,Hu TM,Liu SW,Zhang JY,Wu Y,Ma R,Wu JZ,Chen D,Feng JF

    更新日期:2018-02-13 00:00:00

  • Biosynthesis of the C-terminal amide in peptide hormones.

    abstract::Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of amidating enzymes, co-factors and regulation, mechanism and specificity of the amidating reaction, and multiple forms of the amidating enzyme and glycosylation. Discussion is presented on as...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Bradbury AF,Smyth DG

    更新日期:1987-12-01 00:00:00

  • The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer.

    abstract::We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Jia Y,Zhao LM,Bai HY,Zhang C,Dai SL,Lv HL,Shan BE

    更新日期:2019-01-08 00:00:00

  • Interactions at the membrane surface studied by spin label ESR spectroscopy.

    abstract::A range of different types of interactions at biological membrane surfaces have been studied using various different spin label electron spin resonance (ESR) techniques. These include: (1) the interfacial ionization of local anaesthetics, (2) the binding of peripheral membrane proteins, (3) the membrane insertion of t...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Marsh D

    更新日期:1999-08-01 00:00:00

  • Androgen-linked control of rat liver carbonic anhydrase III.

    abstract::The concentration of carbonic anhydrase III (CAIII) in male rat liver was found to be 30 times greater than that in the female. Castration of male rats led to marked reduction in liver CAIII concentrations which could be partially restored to control levels by testosterone replacement. Marked developmental and senesce...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Shiels A,Jeffery S,Phillips IR,Shephard EA,Wilson CA,Carter ND

    更新日期:1983-05-01 00:00:00

  • Long noncoding RNA CYTOR sponges miR-195 to modulate proliferation, migration, invasion and radiosensitivity in nonsmall cell lung cancer cells.

    abstract::Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progres...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang J,Li W

    更新日期:2018-12-18 00:00:00

  • lncRNA-PCAT1 rs2632159 polymorphism could be a biomarker for colorectal cancer susceptibility.

    abstract::Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Yang ML,Huang Z,Wu LN,Wu R,Ding HX,Wang BG

    更新日期:2019-07-12 00:00:00

  • The relationship between the chromophore moiety and the cation binding sites in bacteriorhodopsin.

    abstract::Bleaching of the purple membrane strongly reduces the number of divalent cation binding sites as well as their affinities. Conversely, deionization of the bleached membrane drastically inhibits the chromophore regeneration. Proteolysis experiments using bromelain show that the bleached membrane has an additional cleav...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Duñach M,Seigneuret M,Rigaud JL,Padrós E

    更新日期:1986-11-01 00:00:00

  • Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway.

    abstract::The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Wang XJ,Xiao JJ,Liu L,Jiao HC,Lin H

    更新日期:2017-11-17 00:00:00

  • Protein disulfide isomerase does not act as an unfoldase in the disassembly of cholera toxin.

    abstract::Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Cherubin P,Guyette J,Taylor M,O'Donnell M,Herndon L,Burress H,Riad A,Tatulian SA,Teter K

    更新日期:2018-09-07 00:00:00

  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains.

    abstract::Gram negative bacterial infection is a leading cause of fatality and is attributed, at least in part, to the bacteria's capacity to persist in the host in spite of appropriate antibiotic therapy. It has been suggested that bacteria evade antibiotics by hiding within host cells. We sought to investigate this important ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Shin JS,Gao Z,Abraham SN

    更新日期:1999-10-01 00:00:00

  • Studies on the subcellular localization and role of glutathione-insulin transhydrogenase in rat liver.

    abstract::125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplas...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Chowdhary BK,Smith GD,Mahler R,Peters TJ

    更新日期:1983-04-01 00:00:00

  • Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.

    abstract::C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and...

    journal_title:Bioscience reports

    pub_type: 杂志文章,评审


    authors: Radha V,Mitra A,Dayma K,Sasikumar K

    更新日期:2011-08-01 00:00:00

  • Whole exome sequencing of a family revealed a novel variant in the CHM gene, c.22delG p.(Glu8Serfs*4), which co-segregated with choroideremia.

    abstract::Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Dan H,Li T,Lei X,Huang X,Xing Y,Shen Y

    更新日期:2020-05-29 00:00:00

  • OPN gene locus is associated with the risk of knee osteoarthritis: a case-control study.

    abstract:: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Shang H,Hao Y,Hu W,Hu X,Jin Q

    更新日期:2019-02-27 00:00:00

  • Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway.

    abstract::Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomat...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhao H,Liu M,Liu H,Suo R,Lu C

    更新日期:2020-03-27 00:00:00

  • Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.

    abstract::Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer's disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex (EC) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. Here, ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ

    更新日期:2020-02-28 00:00:00

  • Effect of rivaroxaban on preventing deep vein thrombosis in aged diabetics with femoral neck fractures after hip replacement.

    abstract::The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided into the rivaroxaban and control groups. Reaction time (R time), ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Zhang YM,Jiang X,Sun YS

    更新日期:2017-06-21 00:00:00

  • Disturbances in T-cell subpopulations in B-cell chronic lymphocytic leukaemia.

    abstract::The relative proportions of immunoregulatory T-cell subpopulations defined by OKT monoclonal antibodies are disturbed in chronic lymphocytic leukaemia (CLL) patients (even early mild cases) compared with normal subjects in the same age range. The mean ratio OKT4+:OKT8+ (helper:suppressor/cytotoxic) is reversed from th...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Johnstone AP,Height S,Millard RE

    更新日期:1982-08-01 00:00:00

  • Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.

    abstract:BACKGROUND:Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Yi S,Xu J,Shi H,Li W,Li Q,Sun YP

    更新日期:2020-06-26 00:00:00

  • AMP hydrolysis in soluble and microsomal rat cardiac cell fractions: kinetic characterization and molecular identification of 5'-nucleotidase.

    abstract::The present study describes the enzymatic properties and molecular identification of 5'-nucleotidase in soluble and microsomal fractions from rat cardiac ventricles. Using AMP as a substrate, the results showed that the cation and the concentration required for maximal activity in the two fractions was magnesium at a ...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Pochmann D,Innocente AM,Cotomacci G,Barreto-Chaves ML,Sarkis JJ

    更新日期:2008-10-01 00:00:00

  • Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11.

    abstract::Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

    更新日期:2019-07-25 00:00:00

  • Prognostic significance of microRNA-135 in patients with digestive system cancers: a systematic review and meta-analysis.

    abstract:BACKGROUND:MicroRNA-135 (miR-135) is a well-known non-coding RNA that has been demonstrated to participate in tumorigenesis and cancer development; however, the clinical prognostic value of miR-135 in digestive system cancers remains controversial. This meta-analysis aims to explore the potential value of miR-135 as a ...

    journal_title:Bioscience reports

    pub_type: 杂志文章,meta分析


    authors: Chao C,Sang C,Wang M,Wang Z,Li Y,Luo G,Zhang X

    更新日期:2019-12-20 00:00:00

  • The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.

    abstract::Cilia and flagella are critical organelles with conserved internal structures and diverse developmental and physiological processes according to cell type. Although the core components of structures are shared with thousands of associated proteins involved in cilia or flagella formation, we hypothesized that some unkn...

    journal_title:Bioscience reports

    pub_type: 杂志文章


    authors: Li ZZ,Zhao WL,Wang GS,Gu NH,Sun F

    更新日期:2020-01-31 00:00:00