Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse.

abstract：:Gram negative bacterial infection is a leading cause of fatality and is attributed, at least in part, to the bacteria's capacity to persist in the host in spite of appropriate antibiotic therapy. It has been suggested that bacteria evade antibiotics by hiding within host cells. We sought to investigate this important ...

journal_title：Bioscience reports

authors： Shin JS,Gao Z,Abraham SN

更新日期：1999-10-01 00:00:00

abstract：:Hospital-acquired infections are common in burn patients and are the major contributors of morbidity and mortality. Bacterial infections such as Staphylococcus aureus (S. aureus) and Acinetobacter baumannii (A. baumannii) are difficult to treat due to their biofilm formation and rapidly acquiring resistance to antibio...

journal_title：Bioscience reports

authors： Khan A,Xu M,Wang T,You C,Wang X,Ren H,Zhou H,Khan A,Han C,Li P

更新日期：2019-06-18 00:00:00

abstract：: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...

journal_title：Bioscience reports

authors： Shang H,Hao Y,Hu W,Hu X,Jin Q

更新日期：2019-02-27 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...

journal_title：Bioscience reports

authors： Liu X,Cao X,Wang S,Ji G,Zhang S,Li H

更新日期：2017-01-17 00:00:00

abstract：:Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...

journal_title：Bioscience reports

authors： Hui J,Pang SW

更新日期：2019-02-19 00:00:00

abstract：:Mycoplasma pneumoniae is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered M. pneumoniae virulence factor that can produce H2S to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not...

journal_title：Bioscience reports

authors： Li S,Xue G,Zhao H,Feng Y,Yan C,Cui J,Sun H

更新日期：2019-01-18 00:00:00

abstract：:Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC based on microarray-based analysis. Hereby, we aimed to characterize the...

journal_title：Bioscience reports

authors： Xu G,Wei X,Tu Q,Zhou C

更新日期：2020-01-31 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:The cytosolic Ca2+ activity of insulin-releasing clonal cells (RINm5F) was studied with the intracellular fluorescent indicator quin-2. When the extracellular Ca2+ concentration was 1 mM, the basal cytosolic Ca2+ activity was 101 +/- 5 nM. Depolarization with 25 mM K+ increased this Ca2+ activity to at least 318 nM, a...

journal_title：Bioscience reports

authors： Rorsman P,Berggren PO,Gylfe E,Hellman B

更新日期：1983-10-01 00:00:00

abstract：:Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is invo...

journal_title：Bioscience reports

authors： Bai Y,Sun X,Chu Q,Li A,Qin Y,Li Y,Yue E,Wang H,Li G,Zahra SM,Dong C,Jiang Y

更新日期：2018-02-12 00:00:00

abstract：:Rabbit reticulocyte lysates, gel filtered on Sephadex G-25 with or without ATP (or its analogs), were preincubated at 37 degrees C and their subsequent binding to p3A4,3'-[32P]pCp was studied. Lysates filtered without ATP or in the presence of 0.1 mM 8-bromo-ATP, 1,N6-etheno-ATP, or ITP showed a time-dependent decreas...

journal_title：Bioscience reports

authors： Wu JM,Wertheimer SJ,Eslami B,Figuereido JC,Goswami BB

更新日期：1985-12-01 00:00:00

abstract：:Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its b...

journal_title：Bioscience reports

authors： Li X,Lin F,Wu Y,Liu N,Wang J,Chen R,Lu Z

更新日期：2019-05-10 00:00:00

abstract：:Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed...

journal_title：Bioscience reports

authors： Wu X,Chen X,Mi W,Wu T,Gu Q,Huang H

更新日期：2017-10-11 00:00:00

abstract：:Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant stu...

journal_title：Bioscience reports

authors： Zhang M,Shi M,Zhao Y

更新日期：2018-07-06 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00

abstract：:It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized haemolysed blood was higher than that in the fraction ...

journal_title：Bioscience reports

authors： Picó C,Pons A,Palou A

更新日期：1991-08-01 00:00:00

abstract：:Objective: To explore whether aspirin (ASA) enhances the sensitivity of hepatocellular carcinoma (HCC) side population (SP) cells to doxorubicin (Doxo) via miR-491/ATP-binding cassette sub-family G member 2 (ABCG2).Methods: Non-SP and SP cells were isolated from MHCC-97L cell line using flow cytometry analysis and flu...

journal_title：Bioscience reports

authors： Xie ZY,Liu MS,Zhang C,Cai PC,Xiao ZH,Wang FF

更新日期：2018-11-09 00:00:00

abstract：:Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...

journal_title：Bioscience reports

authors： Walter H,Krob EJ

更新日期：1989-12-01 00:00:00

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：:Triacylglycerol/fatty acid substrate cycling was measured in vivo in brown adipose tissue (BAT) and white adipose tissue (WAT) of fed, starved and refed rats. Starvation (24h) significantly decreased the rate of cycling in BAT, and refeeding chow diet led to a rapid, 6-fold increase in cycling. Cycling rate in WAT was...

journal_title：Bioscience reports

authors： Mercer SW,Williamson DH

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...

journal_title：Bioscience reports

authors： Zhou P,Xie Y,Yan Z,Liu X,Hua H

更新日期：2019-11-29 00:00:00

abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...

journal_title：Bioscience reports

authors： Wang J,Xu W,Zhao H,Chen J,Zhu B,Li X,Deng D,Wang J,Liu J,Yu Y,Xiao H,Wang W

更新日期：2019-03-22 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00

abstract：:Escherichia coli accumulates K+ by means of multiple transport systems, of which TrkA is the most prominent at neutral and alkaline pH while Kup is major at acidic pH. In the present study, K+ uptake was observed with cells grown under fermentative conditions at an initial pH of 9.0 and 7.3 (the medium pH decreased to...

journal_title：Bioscience reports

authors： Trchounian A,Kobayashi H

更新日期：2000-08-01 00:00:00

abstract：:Mitochondrial disorders encompass any medical specialty and affect patients at any age. Likewise, the spectrum of clinical and genetic signatures of these disorders is ample, making a precise diagnosis difficult. We will report some of the major clinical phenotypes observed in infancy, their underlining molecular feat...

journal_title：Bioscience reports

authors： Carrozzo R,Piemonte F,Tessa A,Lucioli S,Rizza T,Meschini MC,Fattori F,Santorelli FM

更新日期：2007-06-01 00:00:00

abstract：:Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1-3-oligosaccharides. Maximal oligosaccharide-glucosidase activity was obtained at pH 6.2 and a detergent concentration of 0.5% Triton X-100. This activity could be distinguished from non-specific alpha-glucosidase acti...

journal_title：Bioscience reports

authors： Hettkamp H,Bause E,Legler G

更新日期：1982-11-01 00:00:00

abstract：:The proton conductance of the mitochondrial inner membrane can be quantified by applying Ohm's law to the experimentally determined protonmotive force and the proton current flowing around the proton circuit in the absence of ATP synthesis or ion transport. This last parameter is derived from the rate of State 4 respi...

journal_title：Bioscience reports

authors： Nicholls DG

更新日期：1997-06-01 00:00:00

abstract：:This is the first report of its kind that well demonstrates that a lectin from Phytolacca americana [Pa-2 (P. americana lectin-2)] can also be intrinsically unordered, based on the results obtained by CD, tryptophan fluorescence, ANS (8-anilinonaphthalene-1-sulfonic acid) binding, acrylamide quenching, DLS (dynamic li...

journal_title：Bioscience reports

authors： Ahmad E,Kamranur Rahman S,Masood Khan J,Varshney A,Hasan Khan R

更新日期：2009-11-23 00:00:00

abstract：:Accumulating evidence demonstrates that long non-coding RNAs (LncRNAs) play important roles in regulating gene expression and are involved in various cancers, including colorectal cancer (CRC). However, LncRNA profiles in CRC remain largely unknown. The present study aims to find the key LncRNA associated with CRC and...

journal_title：Bioscience reports

authors： Sun L,Xue H,Jiang C,Zhou H,Gu L,Liu Y,Xu C,Xu Q

更新日期：2016-05-06 00:00:00

abstract：:A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...

journal_title：Bioscience reports

authors： Merritt JE,Dobson PR,Wojcikiewicz RJ,Baird JG,Brown BL

更新日期：1984-12-01 00:00:00