Abstract:
:Radioactivity from [14C] adenosine was linearly incorporated into tissue nucleotides in perfused rat hearts. All the TCA-extractable 14C was confined to the purine nucleoside phosphates for up to 1 h of perfusion. Radioactivity was also incorporated linearly into the TCA-insoluble fraction, which by 40 min accounted for 24% of the tissue 14 C. Estimates based on precursor specific radioactivity suggest that at least 0.6 micro mol/g of the mononucleotide is in this stable insoluble form. Following 2 min total ischaemia, the tissue nucleotide content and soluble radioactivity decreased while the insoluble radioactivity showed a corresponding increase to account now for 35% of the tissue radiolabel. This redistribution was rapidly reversed by post-ischaemic reperfusion. A possible function for the rapid reversible sequestration of adenine nucleotides in ischaemia is proposed.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Hutchinson WL,Bates DJ,Perrett D,Mowbray Jdoi
10.1007/BF01114819subject
Has Abstractpub_date
1981-11-01 00:00:00pages
857-63issue
11eissn
0144-8463issn
1573-4935journal_volume
1pub_type
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