Sequence analysis of a cDNA clone encoding the C-terminal end of human complement factor H.

abstract：:Micro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the...

journal_title：Bioscience reports

authors： Xue HY,Yuan L,Cao YJ,Fan YP,Chen XL,Huang XZ

更新日期：2016-06-03 00:00:00

abstract：:Native bovine parathyroid hormone (bPTH) was found to be readily cleaved with human leukocyte elastase to yield the fragments bPTH(1-41) and bPTH(42-84). These were then isolated by reverse-phase HPLC and characterised by gas-phase sequencing and amino acid analysis. The biological activities of these fragments were a...

journal_title：Bioscience reports

authors： Barling PM,Lowe C

更新日期：1987-01-01 00:00:00

abstract：:Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...

journal_title：Bioscience reports

authors： Imai A,Matsunami K,Iida K,Tamaya T

更新日期：1990-02-01 00:00:00

abstract：:C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and...

journal_title：Bioscience reports

authors： Radha V,Mitra A,Dayma K,Sasikumar K

更新日期：2011-08-01 00:00:00

abstract：:To the best of our knowledge, this is the first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction nomogram for patients with LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations of the survival probability when com...

journal_title：Bioscience reports

authors： Cui J,Wang L,Zhong W,Chen Z,Tan X,Yang H,Chen J,Liu G

更新日期：2020-08-28 00:00:00

abstract：:Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) plays important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in...

journal_title：Bioscience reports

authors： Xu D,Yu J,Gao G,Lu G,Zhang Y,Ma P

更新日期：2018-02-02 00:00:00

abstract：:Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which ...

journal_title：Bioscience reports

authors： Epand RM

更新日期：1986-07-01 00:00:00

abstract：:Cholera toxin (CT) is composed of a disulfide-linked A1/A2 heterodimer and a ring-like, cell-binding B homopentamer. The catalytic A1 subunit must dissociate from CTA2/CTB5 to manifest its cellular activity. Reduction of the A1/A2 disulfide bond is required for holotoxin disassembly, but reduced CTA1 does not spontane...

journal_title：Bioscience reports

authors： Cherubin P,Guyette J,Taylor M,O'Donnell M,Herndon L,Burress H,Riad A,Tatulian SA,Teter K

更新日期：2018-09-07 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:The cytosolic Ca2+ activity of insulin-releasing clonal cells (RINm5F) was studied with the intracellular fluorescent indicator quin-2. When the extracellular Ca2+ concentration was 1 mM, the basal cytosolic Ca2+ activity was 101 +/- 5 nM. Depolarization with 25 mM K+ increased this Ca2+ activity to at least 318 nM, a...

journal_title：Bioscience reports

authors： Rorsman P,Berggren PO,Gylfe E,Hellman B

更新日期：1983-10-01 00:00:00

abstract：:The ways in which certain inorganic elements are used in essential roles within biological systems generally are described. The two roles stressed are (1) electrolytic charge movements and (2) electronic charge movement. The value of helical proteins inside and outside membranes as mechanical coupling devices is analy...

journal_title：Bioscience reports

authors： Williams RJ

更新日期：1988-12-01 00:00:00

abstract：:Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...

journal_title：Bioscience reports

authors： Zhang G,Zhang K,Li C,Li Y,Li Z,Li N,Zhou Q,Shen L

更新日期：2019-05-14 00:00:00

abstract：:The present study was designed to investigate the protective effect of moracin on primary culture of nucleus pulposus cells in intervertebral disc and explore the underlying mechanism. Moracin treatment significantly inhibited the LPS-induced inflammatory cytokine accumulation (IL-1β, IL-6 and TNF-α) in nucleus pulpos...

journal_title：Bioscience reports

authors： Gu R,Huang Z,Liu H,Qing Q,Zhuan Z,Yang L,Su Z,Huang W

更新日期：2019-12-20 00:00:00

abstract：:Some medicinal herbs and compounds are known to target cancer cells, but the success of them as anticancer compounds depends to a large extent on their ability to activate pathways that kill cancer cells by arresting cell cycle and inducing apoptosis. The aim of the present study was to determine the anticancer effect...

journal_title：Bioscience reports

authors： Asadi-Samani M,Rafieian-Kopaei M,Lorigooini Z,Shirzad H

更新日期：2019-01-11 00:00:00

abstract：:Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...

journal_title：Bioscience reports

authors： Thompson MG,Pascal M,Mackie SC,Thom A,Morrison KS,Backwell FR,Palmer RM

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:X inactivate-specific transcript (XIST) is an attractive long noncoding RNA (lncRNA) functioning as an indicator of various human tumors, including laryngeal squamous cell carcinoma (LSCC). The present study was conducted to explore a novel regulatory network of lncRNA XIST in LSCC cells. MATERIALS AND METHO...

journal_title：Bioscience reports

authors： Liu C,Lu Z,Liu H,Zhuang S,Guo P

更新日期：2020-04-30 00:00:00

abstract：:Oral vaccination requires an antigen delivery vehicle to protect the antigen and to enhance translocation of the antigen to the mucosa-associated lymphoid tissue. A variety of antigen delivery vehicles including liposomes have been studied for mucosal immunization. The advantages of liposome formulations are their par...

journal_title：Bioscience reports

authors： Zho F,Neutra MR

更新日期：2002-04-01 00:00:00

abstract：:This study proposed a deep learning (DL) algorithm to predict survival in patients with colon adenocarcinoma (COAD) based on multi-omics integration. The survival-sensitive model was constructed using an autoencoder for DL implementation based on The Cancer Genome Atlas (TCGA) data of patients with COAD. The autoencod...

journal_title：Bioscience reports

authors： Lv J,Wang J,Shang X,Liu F,Guo S

更新日期：2020-12-01 00:00:00

abstract：:Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed (EECLS) in Wistar rats to measure its safety profile. The single do...

journal_title：Bioscience reports

authors： Belemkar S,Shendge PN

更新日期：2021-01-29 00:00:00

abstract：:Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a screening method for RBC vesicle shedding using the Ca(2+) ionophore...

journal_title：Bioscience reports

authors： Kostova EB,Beuger BM,Klei TR,Halonen P,Lieftink C,Beijersbergen R,van den Berg TK,van Bruggen R

更新日期：2015-04-16 00:00:00

abstract：:eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2-3 phosphates per eNOS monomer. Phosphorylation decreases NO synthesis...

journal_title：Bioscience reports

authors： Salerno JC,Ghosh DK,Razdan R,Helms KA,Brown CC,McMurry JL,Rye EA,Chrestensen CA

更新日期：2014-09-17 00:00:00

abstract：:A non-ionic detergent such as Lubrol-PX extracts in soluble form the VIP-binding structures of rat liver plasma membranes. Detergent-solubilized proteins bind specifically [125I]VIP and the complex tracer-protein is identified by the use of Sepharose 6B columns. The interaction is only possible in the absence of deter...

journal_title：Bioscience reports

authors： Guerrero JM,Calvo JR,Garrido MR,Molinero P,Osuna C,Jiménez J,Goberna R

更新日期：1986-01-01 00:00:00

abstract：:Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progres...

journal_title：Bioscience reports

authors： Zhang J,Li W

更新日期：2018-12-18 00:00:00

abstract：:Glioblastomas (GBMs) are a lethal class of brain cancer, with a median survival <15 months in spite of therapeutic advances. The poor prognosis of GBM is largely attributed to acquired chemotherapy resistance, and new strategies are urgently needed to target resistant glioma cells. Here we report a role for miR-299-5p...

journal_title：Bioscience reports

authors： Peng Y,He X,Chen H,Duan H,Shao B,Yang F,Li H,Yang P,Zeng Y,Zheng J,Li Y,Hu J,Lin L,Teng L

更新日期：2018-09-12 00:00:00

abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...

journal_title：Bioscience reports

authors： Huang F,Wang J,Xu Y,Zhang Y,Xu N,Yin L

更新日期：2020-06-26 00:00:00

abstract：:The nucleotide sequence of the thioredoxin gene from Escherichia coli was determined. The structural gene was identified on a cloned 3-kb PvuII fragment by hybridization with a synthetic oligodeoxyribonucleotide corresponding to a part of the amino acid sequence of thioredoxin. Restriction-enzyme fragments were used a...

journal_title：Bioscience reports

authors： Höög JO,von Bahr-Lindström H,Josephson S,Wallace BJ,Kushner SR,Jörnvall H,Holmgren A

更新日期：1984-11-01 00:00:00

abstract：:The purpose of this meta-analysis was to evaluate the beneficial and adverse effects of tripterygium glycosides (TGs) combined with angiotensin II receptor blocker (ARB) on diabetic nephropathy (DN). We searched for randomized controlled trials (RCTs) in PubMed, Embase, Cochrane Central Register of Controlled Trials, ...

journal_title：Bioscience reports

authors： Wu X,Huang Y,Zhang Y,He C,Zhao Y,Wang L,Gao J

更新日期：2020-11-27 00:00:00

abstract：:The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...

journal_title：Bioscience reports

authors： Jencks WP

更新日期：1995-10-01 00:00:00

abstract：:Members of the ADAM (a disintegrin and metalloproteinase) family of proteins possess a multidomain architecture which permits functionalities as adhesion molecules, signalling intermediates and proteolytic enzymes. ADAM8 is found on immune cells and is induced by multiple pro-inflammatory stimuli suggesting a role in ...

journal_title：Bioscience reports

authors： Hall T,Leone JW,Wiese JF,Griggs DW,Pegg LE,Pauley AM,Tomasselli AG,Zack MD

更新日期：2009-08-01 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00