Abstract:
:C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and many cellular functions in adult tissues. C3G participates in regulating functions that require cytoskeletal remodelling such as adhesion, migration, maintenance of cell junctions, neurite growth and vesicle traffic. C3G is spatially and temporally regulated to act on Ras family GTPases Rap1, Rap2, R-Ras, TC21 and Rho family member TC10. Increased C3G protein levels are associated with differentiation of various cell types, indicating an important role for C3G in cellular differentiation. In signalling pathways, C3G serves functions dependent on catalytic activity as well as protein interaction and can therefore integrate signals necessary for the execution of more than one cellular function. This review summarizes our current knowledge of the biology of C3G with emphasis on its role as a transducer of signals to the actin cytoskeleton. Deregulated C3G may also contribute to pathogenesis of human disorders and therefore could be a potential therapeutic target.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Radha V,Mitra A,Dayma K,Sasikumar Kdoi
10.1042/BSR20100094subject
Has Abstractpub_date
2011-08-01 00:00:00pages
231-44issue
4eissn
0144-8463issn
1573-4935pii
BSR20100094journal_volume
31pub_type
杂志文章,评审abstract::Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (RRBP1) has been shown to participate in various aspects of malignancies. The clinical significance of RRBP1 and its involvement in the epithelial ovarian cancer have yet to be studied. The aim of the present study was to investigate the ...
journal_title:Bioscience reports
pub_type: 临床试验,杂志文章
doi:10.1042/BSR20190656
更新日期:2019-07-23 00:00:00
abstract::The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in di...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20171440
更新日期:2018-02-13 00:00:00
abstract::Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.Methods: In the present study, 154 patients wit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191831
更新日期:2019-08-23 00:00:00
abstract::Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated wit...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140012
更新日期:2014-04-01 00:00:00
abstract::Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181277
更新日期:2019-01-18 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb. Increasing cases of multidrug-resistant (MDR) tuberculosis (MDR-TB) is a serious public health problem to TB control i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181746
更新日期:2019-05-31 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150034
更新日期:2015-05-07 00:00:00
abstract::Oral vaccination requires an antigen delivery vehicle to protect the antigen and to enhance translocation of the antigen to the mucosa-associated lymphoid tissue. A variety of antigen delivery vehicles including liposomes have been studied for mucosal immunization. The advantages of liposome formulations are their par...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020103109483
更新日期:2002-04-01 00:00:00
abstract::Tuberculosis (TB), a leading infectious disease caused by Mycobacterium tuberculosis strain, takes four human lives every minute globally. Paucity of knowledge on M. tuberculosis virulence and antibiotic resistance is the major challenge for tuberculosis control. We have identified 47 acetyltransferases in the M. tube...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191661
更新日期:2019-12-20 00:00:00
abstract:AIM:To explore the prognostic value of clusterin (CLU) in hepatocellular carcinoma (HCC) patients treated with oxaliplatin (OXA). METHODS:Relative expression of plasma CLU mRNA was examined via fluorescence quantitative real-time PCR (qRT-PCR), and CLU protein level in tissue samples was detected through immunohistoch...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200071
更新日期:2020-02-28 00:00:00
abstract::A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192345
更新日期:2020-01-31 00:00:00
abstract::Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191554
更新日期:2020-01-31 00:00:00
abstract::The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently...
journal_title:Bioscience reports
pub_type: 杂志文章,收录出版
doi:10.1042/BSR20171184
更新日期:2018-01-19 00:00:00
abstract::Reactive oxygen species (ROS) overproduction and renal tubular epithelial cell (TEC) apoptosis are key mechanisms of contrast-induced acute kidney injury (CI-AKI). Mitochondria are the main source of intracellular ROS. In the present study, the characteristics of mitophagy and the effects of rapamycin on contrast-indu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180876
更新日期:2018-11-20 00:00:00
abstract:OBJECTIVES:To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). METHODS:Databases were searched electronically and manually to identify case-control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. ...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20191519
更新日期:2019-11-29 00:00:00
abstract::Peanut (Arachis hypogaea) seed lectin, PNA is widely used to identify tumor specific antigen (T-antigen), Galbeta1-3GalNAc on the eukaryotic cell surface. The functional amino acid coding region of a cDNA clone, pBSH-PN was PCR amplified and cloned downstream of the polyhedrin promoter in the Autographa californica nu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1020234005099
更新日期:1999-06-01 00:00:00
abstract::Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180243
更新日期:2018-12-07 00:00:00
abstract::31p nuclear magnetic resonance (NMR) spectra have been obtained from animal and human tumours grown in laboratory rodents. The tumour cells are only slightly more acid than the surrounding muscle but they tend to have large Pi and sugar phosphate peaks, suggesting anoxia, and large but variable phosphodiester peaks. T...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114835
更新日期:1982-09-01 00:00:00
abstract::Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170203
更新日期:2018-04-27 00:00:00
abstract::Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181635
更新日期:2019-05-14 00:00:00
abstract::Choroideremia is a complex form of blindness-causing retinal degeneration. The aim of the present study was to investigate the pathogenic variant and molecular etiology associated with choroideremia in a Chinese family. All available family members underwent detailed ophthalmological examinations. Whole exome sequenci...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200067
更新日期:2020-05-29 00:00:00
abstract::Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170650
更新日期:2017-07-16 00:00:00
abstract:OBJECTIVE:X inactivate-specific transcript (XIST) is an attractive long noncoding RNA (lncRNA) functioning as an indicator of various human tumors, including laryngeal squamous cell carcinoma (LSCC). The present study was conducted to explore a novel regulatory network of lncRNA XIST in LSCC cells. MATERIALS AND METHO...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193172
更新日期:2020-04-30 00:00:00
abstract::Maclurin, the potent non-specific blood-group hemagglutinin present in extracts of Maclura pomifera, has been purified by a new biospecific affinity-chromatographic procedure. Additional studies have indicated that this hemagglutinin occurs as five closely related tetrameric protein isoforms derived from two non-coval...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01136724
更新日期:1982-04-01 00:00:00
abstract::A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether variants in PPAR-encoding genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a la...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201083
更新日期:2020-07-31 00:00:00
abstract::The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160265
更新日期:2017-01-17 00:00:00
abstract::The increase in % phosphorylase a associated with muscle contraction is reversed after a few minutes despite continued contractile activity. The present study was undertaken to determine whether adrenaline can activate phosphorylase after deactivation has occurred during prolonged stimulation of contraction. We found ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115118
更新日期:1982-05-01 00:00:00
abstract::Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled polypeptide. Secretion of the non-glycosylated protein ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119592
更新日期:1985-03-01 00:00:00
abstract::Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. The antibodies are both IgG - gamma 1 - subclass and are directed against different epitopes on the human Factor H molecule. One of the antibodies, MRC OX 24, increases the cofactor activity of Factor H in ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01120205
更新日期:1983-12-01 00:00:00
abstract::Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism t...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171667
更新日期:2018-02-08 00:00:00