Identification of signalling cascades involved in red blood cell shrinkage and vesiculation.

abstract：:Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of l...

journal_title：Bioscience reports

authors： Huang T,Wang J,Zhou Y,Zhao Y,Hang D,Cao Y

更新日期：2019-05-14 00:00:00

abstract：:Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific end...

journal_title：Bioscience reports

authors： Zhang M,Wu C

更新日期：2020-10-30 00:00:00

abstract：:Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, the specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regul...

journal_title：Bioscience reports

authors： Gao R,Feng Q,Tan G

更新日期：2019-07-10 00:00:00

abstract：:Diabetes mellitus (DM) is a potential etiology of disc degeneration. Glucagon-like peptide-1 (GLP-1) is currently regarded as a powerful treatment option for type 2 diabetes. Apart from the beneficial effects on glycaemic control, GLP-1 has been reported to exert functions in a variety of tissues on modulation of cell...

journal_title：Bioscience reports

authors： Ming-Yan Y,Jing Z,Shu-Qin G,Xiao-Liang B,Zhi-Hong L,Xue Z

更新日期：2019-08-19 00:00:00

abstract：:Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...

journal_title：Bioscience reports

authors： Liu G,Zhou J,Dong M

更新日期：2019-03-22 00:00:00

abstract：:Isoliquiritigenin (ISL), a natural product isolated from licorice root, exhibits anti-gastric cancer effects. However, applications of ISL are still limited in clinical practice due to its poor bioavailability. To discovery of more effective anti-gastric cancer agents based on ISL, aldol condensation reaction was appl...

journal_title：Bioscience reports

authors： Huang F,Wang J,Xu Y,Zhang Y,Xu N,Yin L

更新日期：2020-06-26 00:00:00

abstract：:Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...

journal_title：Bioscience reports

authors： Huang Y,Fan G,Yang F

更新日期：1994-08-01 00:00:00

abstract：:In the present study, we investigated the role of lncRNA SAMMSON in hepatocellular carcinoma (HCC). We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. miR-9-3p was down-regulated in HCC tiss...

journal_title：Bioscience reports

authors： Yang S,Cai H,Hu B,Tu J

更新日期：2019-07-05 00:00:00

abstract：:Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...

journal_title：Bioscience reports

authors： Warrier VU,Makandar AI,Garg M,Sethi G,Kant R,Pal JK,Yuba E,Gupta RK

更新日期：2019-10-30 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is considered as a direct reason for the failure of clinic treatment in hepatocellular carcinoma (HCC). Growing evidences have demonstrated that miRNAs play an important role in regulation of stem cell proliferation, differentiation and self-renewal and their aberrances cause ...

journal_title：Bioscience reports

authors： Liu Q,Xu Y,Wei S,Gao W,Chen L,Zhou T,Wang Z,Ying M,Zheng Q

更新日期：2015-05-22 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:This review covers the recent progress in the elucidation of the structure of photosystem II (PSII). Because much of the structural information for this membrane protein complex has been revealed by electron microscopy (EM), the review will also consider the specific technical and interpretation problems that arise wi...

journal_title：Bioscience reports

authors： Nicholson WV,Ford RC,Holzenburg A

更新日期：1996-04-01 00:00:00

abstract：:The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

journal_title：Bioscience reports

authors： Xu SY,Song N,Xiao SJ,Gao TX

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND/AIMS:MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. METHODS:The expression of miR-122, silent information regulator 1 (SIRT1), collagen II, a...

journal_title：Bioscience reports

authors： Bai Y,Chen K,Zhan J,Wu M

更新日期：2020-06-26 00:00:00

abstract：:The proton conductance of the mitochondrial inner membrane can be quantified by applying Ohm's law to the experimentally determined protonmotive force and the proton current flowing around the proton circuit in the absence of ATP synthesis or ion transport. This last parameter is derived from the rate of State 4 respi...

journal_title：Bioscience reports

authors： Nicholls DG

更新日期：1997-06-01 00:00:00

abstract：:Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...

journal_title：Bioscience reports

authors： Sorsa T,Suomalainen K,Turto H,Lindy S

更新日期：1987-12-01 00:00:00

abstract：:Circulating tumor cells can provide important diagnostic and prognostic information of the patients with non-small cell lung cancer (NSCLC). Aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, has been used in various tumors, including NSCLC. In the present study, we isolated the circulating ALDH1+ tumor cell...

journal_title：Bioscience reports

authors： Tian S,Xing YN,Xia P

更新日期：2018-10-31 00:00:00

abstract：:Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is assoc...

journal_title：Bioscience reports

authors： Pi L,Fu L,Xu Y,Che D,Deng Q,Huang X,Li M,Zhang L,Huang P,Gu X

更新日期：2018-05-22 00:00:00

abstract：:Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...

journal_title：Bioscience reports

authors： Bellini T,Degani D,Matteuzzi M,Dallocchio F

更新日期：1990-02-01 00:00:00

abstract：:Using both immunohistological study and photoaffinity labelling with radioactive azido-ATP, evidence is presented that the mitochondrial membranes of the brown adipose tissue of the human adult contain a 32 000-Mr uncoupling protein, which is probably similar to the uncoupling protein of BAT of rodents. ...

journal_title：Bioscience reports

authors： Bouillaud F,Combes-George M,Ricquier D

更新日期：1983-08-01 00:00:00

abstract：AIM:The purpose of the present study was to explore the function and mechanism of tensin 1 (TNS1) in non-small cell lung cancer (NSCLC) progression. METHODS:The expression of TNS1 in NSCLC cells and tissues was assessed by RT-PCR and Western blot. Besides, Kaplan-Meier survival analysis was recruited to explore the as...

journal_title：Bioscience reports

authors： Duan J,Wang L,Shang L,Yang S,Wu H,Huang Y,Miao Y

更新日期：2021-01-29 00:00:00

abstract：:Huaier Granule, a type of traditional Chinese biomedical preparation (TCBP), is considered to be a promising adjuvant therapy for breast cancer. Although an analysis of the published literature has been performed, the exact effects and safety of Huaier Granule remains controversial. Therefore, a wide-ranging systemati...

journal_title：Bioscience reports

authors： Yao X,Wu W,Qu K,Xi W

更新日期：2020-08-28 00:00:00

abstract：:The sites and extents of bisulphite-mediated deamination of cytidine residues in HeLa-cell 5.8 S rRNA within the 5.8 S / 28 S rRNA complex have been determined. Comparison of these data with equivalent data for isolated ('unbound') 5.8 S rRNA suggests that the conformation of several cytidine residues, including inter...

journal_title：Bioscience reports

authors： Kelly JM,Goddard JP

更新日期：1981-05-01 00:00:00

abstract：:Mice and rats are animals commonly used in research and laboratory testing. Compared with other animal species, they harbor many more zoonotic agents. Hymenolepis nana (H. nana) is a common tapeworm that parasitizes both humans and rodents. Although this tapeworm is of socio-economic importance worldwide, information ...

journal_title：Bioscience reports

authors： Metwally DM,Al-Enezy HA,Al-Turaiki IM,El-Khadragy MF,Yehia HM,Al-Otaibi TT

更新日期：2019-02-08 00:00:00

abstract：:The ways in which certain inorganic elements are used in essential roles within biological systems generally are described. The two roles stressed are (1) electrolytic charge movements and (2) electronic charge movement. The value of helical proteins inside and outside membranes as mechanical coupling devices is analy...

journal_title：Bioscience reports

authors： Williams RJ

更新日期：1988-12-01 00:00:00

abstract：:In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...

journal_title：Bioscience reports

authors： Liu S,Li Y,Xu H,Wang K,Li N,Li J,Sun T,Xu Y

更新日期：2016-06-30 00:00:00

abstract：:In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids. Mutants unable to form HMP can be rescued by exogenous HMP, implying the presence of HMP transporters in the plasma membrane and plastids. Analysis of bacterial genomes reve...

journal_title：Bioscience reports

authors： Beaudoin GAW,Johnson TS,Hanson AD

更新日期：2018-03-29 00:00:00

abstract：:Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we assessed mitochondri...

journal_title：Bioscience reports

authors： Bird MJ,Wijeyeratne XW,Komen JC,Laskowski A,Ryan MT,Thorburn DR,Frazier AE

更新日期：2014-11-21 00:00:00

abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

journal_title：Bioscience reports

authors： Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

更新日期：2019-07-25 00:00:00

abstract：:The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of...

journal_title：Bioscience reports

authors： Cai F,Zhang Y,Li J,Huang S,Gao R

更新日期：2020-03-27 00:00:00