Abstract:
:The present study investigated the effects of Isorhamnetin on two types of prostate cancer cells (androgen-independent and androgen-dependent) and explored its possible mechanisms underlying such effects. Treatment with Isorhamnetin significantly inhibited cell growth and induced lactate dehydrogenase (LDH) release of androgen-independent DU145 and PC3 prostate cancer cells, but exhibited almost no toxicity effect on androgen-dependent LNCaP prostate cancer cell line or normal human prostate epithelial PrEC cells, which was achieved by the induction of apoptosis in a mitochondrion-dependent intrinsic apoptotic pathway. Furthermore, Isorhamnetin inhibited cell migration and invasion in concentration-dependent manners by enhancing mesenchymal-epithelial transition (MET) and inhibiting matrix metalloproteinase (MMP) 2 (MMP-2) and MMP-9 overexpression. In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin to be a selective PI3K-Akt-mTOR pathway inhibitor. In summary, these findings propose that Isorhamnetin might be a novel therapeutic candidate for the treatment of androgen-independent prostate cancer.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Cai F,Zhang Y,Li J,Huang S,Gao Rdoi
10.1042/BSR20192826subject
Has Abstractpub_date
2020-03-27 00:00:00issue
3eissn
0144-8463issn
1573-4935pii
222067journal_volume
40pub_type
杂志文章abstract::Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsens...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121566
更新日期:1983-01-01 00:00:00
abstract::Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed (EECLS) in Wistar rats to measure its safety profile. The single do...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202345
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1027364308147
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180018
更新日期:2018-02-13 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章,评审
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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doi:10.1042/BSR20070039
更新日期:2008-10-01 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191661
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
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doi:10.1007/BF01116850
更新日期:1990-02-01 00:00:00
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121951
更新日期:1983-02-01 00:00:00
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191292
更新日期:2019-07-23 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190100
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171667
更新日期:2018-02-08 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
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abstract::Information on the prevalence and type distribution of human papillomavirus (HPV) among Malaysian women is currently limited. The present study therefore aimed to provide an updated estimate on the prevalence and type distribution of HPV among Malaysian women with and without cervical cancer. Total DNA was isolated fr...
journal_title:Bioscience reports
pub_type: 临床试验,杂志文章
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更新日期:2018-03-29 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116998
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journal_title:Bioscience reports
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150084
更新日期:2015-05-22 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181776
更新日期:2019-02-26 00:00:00
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191554
更新日期:2020-01-31 00:00:00
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journal_title:Bioscience reports
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更新日期:2017-12-12 00:00:00
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journal_title:Bioscience reports
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journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119592
更新日期:1985-03-01 00:00:00
abstract::Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesized by processive glycosyltransferases from intracellular sugar nucleotide donors. Here we demonstrate that A...
journal_title:Bioscience reports
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doi:10.1042/BSR20130053
更新日期:2013-09-04 00:00:00