The PLUTO plastidial nucleobase transporter also transports the thiamin precursor hydroxymethylpyrimidine.

abstract：:This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...

journal_title：Bioscience reports

authors： Hidalgo C,Donoso P

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. METHODS:The robust rank aggregation method was used to mine differentially expressed genes...

journal_title：Bioscience reports

authors： Song Y,Tang W,Li H

更新日期：2021-01-29 00:00:00

abstract：:Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...

journal_title：Bioscience reports

authors： Wang J,Xu W,Zhao H,Chen J,Zhu B,Li X,Deng D,Wang J,Liu J,Yu Y,Xiao H,Wang W

更新日期：2019-03-22 00:00:00

abstract：:When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, sig...

journal_title：Bioscience reports

authors： MacManus JP,Watson DC,Yaguchi M

更新日期：1983-11-01 00:00:00

abstract：:Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels...

journal_title：Bioscience reports

authors： Wang W,Shi Y,Li J,Cui W,Yang B

更新日期：2016-04-05 00:00:00

abstract：:3D (three-dimensional) cultures are considered to be an effective method for toxicological studies; however, little evidence has been reported whether 3D cultures have an impact on hepatocellular physiology regarding lipid or glucose metabolism. In the present study, we conducted physiological characterization of hepa...

journal_title：Bioscience reports

authors： Takahashi Y,Hori Y,Yamamoto T,Urashima T,Ohara Y,Tanaka H

更新日期：2015-05-07 00:00:00

abstract：:Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed that purified recombinant YjhC forms Neu5Ac from two dehydrated forms of this compound, 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-ac...

journal_title：Bioscience reports

authors： Kentache T,Thabault L,Peracchi A,Frédérick R,Bommer GT,Van Schaftingen E

更新日期：2020-06-26 00:00:00

abstract：:Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we assessed mitochondri...

journal_title：Bioscience reports

authors： Bird MJ,Wijeyeratne XW,Komen JC,Laskowski A,Ryan MT,Thorburn DR,Frazier AE

更新日期：2014-11-21 00:00:00

abstract：:As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...

journal_title：Bioscience reports

authors： Zhang Y,Bai J,Si W,Yuan S,Li Y,Chen X

更新日期：2020-02-28 00:00:00

abstract：:A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependent hydroxylation of ...

journal_title：Bioscience reports

authors： Kim J,Barsoum IB,Loh H,Paré JF,Siemens DR,Graham CH

更新日期：2020-01-31 00:00:00

abstract：:Heterotopic ossification (HO) is the aberrant formation of mature, lamellar bone in nonosseous tissue. Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disorder that causes progressive HO in the ligaments, tendons, and muscles throughout the body. FOP is attributed to an autosomal mutation...

journal_title：Bioscience reports

authors： Lin H,Shi F,Gao J,Hua P

更新日期：2019-08-02 00:00:00

abstract：:Transfer of Bomirski amelanotic melanoma cells from in vivo to in vitro growth conditions results in occurrence of rapid melanization in their cytoplasm. The melanized cells from primary cell culture initiate tumours in hamsters, which do not contain traces of melanin and resemble typical amelanotic melanoma. ...

journal_title：Bioscience reports

authors： Słomiński A

更新日期：1983-02-01 00:00:00

abstract：:Maclurin, the potent non-specific blood-group hemagglutinin present in extracts of Maclura pomifera, has been purified by a new biospecific affinity-chromatographic procedure. Additional studies have indicated that this hemagglutinin occurs as five closely related tetrameric protein isoforms derived from two non-coval...

journal_title：Bioscience reports

authors： Hearn MT,Smith PK,Mallia AK

更新日期：1982-04-01 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...

journal_title：Bioscience reports

authors： Liu X,Cao X,Wang S,Ji G,Zhang S,Li H

更新日期：2017-01-17 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. MATERIALS AND METHODS:The data used in this research were collected from Google Scholar, Web of Science, CNKI, and ...

journal_title：Bioscience reports

authors： Wang BJ,Chen JY,Guan Y,Liu DC,Cao ZC,Kong J,Wu ZS,Wu WY

更新日期：2021-01-27 00:00:00

abstract：:Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We...

journal_title：Bioscience reports

authors： Han HF,Chen Q,Zhao WW

更新日期：2020-09-30 00:00:00

abstract：:Due to poor prognosis of glioblastoma (GBM), there is an urgent need to develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel therapeutic approach aims to target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile of GAMs correlated with patie...

journal_title：Bioscience reports

authors： Gjorgjevski M,Hannen R,Carl B,Li Y,Landmann E,Buchholz M,Bartsch JW,Nimsky C

更新日期：2019-06-20 00:00:00

abstract：:TRα1 (thyroid hormone receptor α1) is well recognized for its importance in brain development. However, due to the difficulties in predicting TREs (thyroid hormone response elements) in silico and the lack of suitable antibodies against TRα1 for ChIP (chromatin immunoprecipitation), only a few direct TRα1 target genes...

journal_title：Bioscience reports

authors： Dudazy-Gralla S,Nordström K,Hofmann PJ,Meseh DA,Schomburg L,Vennström B,Mittag J

更新日期：2013-03-13 00:00:00

abstract：:The Gram-positive bacterium Staphylococcus pseudintermedius is a leading cause of canine bacterial pyoderma, resulting in worldwide morbidity in dogs. S. pseudintermedius also causes life-threatening human infections. Furthermore, methicillin-resistant S. pseudintermedius is emerging, resembling the human health threa...

journal_title：Bioscience reports

authors： Abate F,Malito E,Cozzi R,Lo Surdo P,Maione D,Bottomley MJ

更新日期：2014-11-24 00:00:00

abstract：:Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...

journal_title：Bioscience reports

authors： Li F,Wei H,Li H,Li X,Hu C,Zhang J,Deng Y,Liao X

更新日期：2019-05-14 00:00:00

abstract：:Safflower (Carthamus tinctorius L.) serves as a reference dicot for investigation of defence mechanisms in Asteraceae due to abundant secondary metabolites and high resistance/tolerance to environmental stresses. In plants, phenylpropanoid and flavonoid pathways are considered as two central defence signalling cascade...

journal_title：Bioscience reports

authors： Dehghan S,Sadeghi M,Pöppel A,Fischer R,Lakes-Harlan R,Kavousi HR,Vilcinskas A,Rahnamaeian M

更新日期：2014-06-25 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in ca...

journal_title：Bioscience reports

authors： Ding B,Lou W,Xu L,Fan W

更新日期：2018-10-09 00:00:00

abstract：:Gamma- and delta-isomers of hexachlorocyclohexane caused marked decreases in the levels of radioactive phospholipids, and increases in the levels of [3H]arachidonate incorporated into free fatty acids in rat renal tubular cells. The increased radioactivity of free fatty acids arises from the decrease of [3H]arachidona...

journal_title：Bioscience reports

authors： Puente-Fraga JC,López-Aparicio P,Senar S,Recio MN,Pérez-Albarsanz MA

更新日期：1995-08-01 00:00:00

abstract：:125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplas...

journal_title：Bioscience reports

authors： Chowdhary BK,Smith GD,Mahler R,Peters TJ

更新日期：1983-04-01 00:00:00

abstract：:miRNAs are non-coding RNA molecules typically 18-22 nucleotides long that can suppress the expression of their target genes. Several laboratories have attempted to identify miRNAs from the pig that are involved in Salmonella infection. These bioinformatics strategies using the newly available genomic sequence are gene...

journal_title：Bioscience reports

authors： Yao M,Gao W,Yang J,Liang X,Luo J,Huang T

更新日期：2016-08-31 00:00:00

abstract：:Heparin causes lysis of the multilamellar liposomes of all three charges, positive, neutral, and negative, and thus releases the entrapped [3H]glucose or chromate. The lytic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with ...

journal_title：Bioscience reports

authors： Patel HM,Parvez N,Field J,Ryman BE

更新日期：1983-01-01 00:00:00

abstract：:The marbled rockfish Sebastiscus marmoratus is an ecologically and economically important marine fish species distributed along the northwestern Pacific coast from Japan to the Philippines. Here, next-generation sequencing was used to generate a whole genome survey dataset to provide fundamental information of its gen...

journal_title：Bioscience reports

authors： Xu SY,Song N,Xiao SJ,Gao TX

更新日期：2020-02-28 00:00:00

abstract：:Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...

journal_title：Bioscience reports

authors： Nag M,Nandi N

更新日期：1991-02-01 00:00:00

abstract：:The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membran...

journal_title：Bioscience reports

authors： Senar S,Gutierrez-Ocaña MT,Perez-Albarsanz MA,Recio MN

更新日期：1991-04-01 00:00:00