The mechanism of coupling chemical and physical reactions by the calcium ATPase of sarcoplasmic reticulum and other coupled vectorial systems.

abstract：:Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms (SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed b...

journal_title：Bioscience reports

authors： Zhou X,Liao F,Zhang J,Qin Y,Xu H,Ding Z,Zhang Y,Zhang F

更新日期：2018-06-27 00:00:00

abstract：:Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during ...

journal_title：Bioscience reports

authors： Zhao H,Zhang J,Shao H,Liu J,Jin M,Chen J,Huang Y

更新日期：2017-07-20 00:00:00

abstract：:We have shown previously that Escherichia coli K92 produces two different capsular polymers known as CA (colanic acid) and PA (polysialic acid) in a thermoregulated manner. The complex Rcs phosphorelay is largely related to the regulation of CA synthesis. Through deletion of rscA and rscB genes, we show that the Rcs s...

journal_title：Bioscience reports

authors： Navasa N,Rodríguez-Aparicio L,Ferrero MÁ,Monteagudo-Mera A,Martínez-Blanco H

更新日期：2013-05-24 00:00:00

abstract：:Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...

journal_title：Bioscience reports

authors： Li B,Yuan Z,Jiang J,Rao Y

更新日期：2018-12-11 00:00:00

abstract：:An antibody was raised to the synthetic pentapeptide pGluHisProGlyLys which, in radioimmunoassay (RIA), could detect the pentapeptide at a level of 10 fmole per tube and exhibited less than 0.5 per cent cross reactivity with a series of related peptides. The RIA was used to demonstrate the presence of C-terminally ext...

journal_title：Bioscience reports

authors： Cockle SM,Smyth DG

更新日期：1986-06-01 00:00:00

abstract：:Breast cancer remains a leading cause of cancer-related mortality in women. In recent years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received increased interest as regulators of breast cancer cell adhesion and invasion. The exostosin (EXT) proteins are glycosyltransferases involved in e...

journal_title：Bioscience reports

authors： Sembajwe LF,Katta K,Grønning M,Kusche-Gullberg M

更新日期：2018-08-31 00:00:00

abstract：BACKGROUND:This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. METHOD:A total of 225 Chinese Han patients with CRC were selected as the study group, and...

journal_title：Bioscience reports

authors： Jin D,Zhang M,Hua H

更新日期：2019-01-15 00:00:00

abstract：:In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of d...

journal_title：Bioscience reports

authors： Connelly LW,Keller RK

更新日期：1984-09-01 00:00:00

abstract：:Background: Endometrial carcinoma (EC) still threatens the health of women. Thus, to explore how long intergenic non-protein coding RNA 01220 regulates the development of EC.Methods: Whole genome expression profile data of EC and paracancerous tissues in TCGA database were downloaded. LINC01220 expression in EC and pa...

journal_title：Bioscience reports

authors： Li Y,Kong C,Wu C,Wang Y,Xu B,Liang S,Ying X

更新日期：2019-07-25 00:00:00

abstract：:Heparin causes lysis of the multilamellar liposomes of all three charges, positive, neutral, and negative, and thus releases the entrapped [3H]glucose or chromate. The lytic effect of heparin is also observed in liposomes prepared from the lipids extracted from human red blood cells. Heparin is found to interact with ...

journal_title：Bioscience reports

authors： Patel HM,Parvez N,Field J,Ryman BE

更新日期：1983-01-01 00:00:00

abstract：:In the present study, we investigated the role of lncRNA SAMMSON in hepatocellular carcinoma (HCC). We found that SAMMSON was up-regulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. miR-9-3p was down-regulated in HCC tiss...

journal_title：Bioscience reports

authors： Yang S,Cai H,Hu B,Tu J

更新日期：2019-07-05 00:00:00

abstract：:Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...

journal_title：Bioscience reports

authors： Chen X,He Y,Xu A,Deng Z,Feng J,Lu F,Yuan Y

更新日期：2019-02-26 00:00:00

abstract：:Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...

journal_title：Bioscience reports

authors： Suleiman MS

更新日期：1985-08-01 00:00:00

abstract：:125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplas...

journal_title：Bioscience reports

authors： Chowdhary BK,Smith GD,Mahler R,Peters TJ

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate the functional roles and clinical significance of microRNA-148a (miR-148a) in the progression of oral squamous cell carcinoma (OSCC). METHODS:Relative expression of miR-148a in OSCC cells and tissues were detected using quantitative real-time polymerase chain reaction (...

journal_title：Bioscience reports

authors： Jia T,Ren Y,Wang F,Zhao R,Qiao B,Xing L,Ou L,Guo B

更新日期：2020-04-30 00:00:00

abstract：:NUF2 (NUF2, Ndc80 kinetochore complex component) plays an important role in kinetochore-microtubule attachment. It has been reported that NUF2 is associated with multiple human cancers. However, the functional role of NUF2 in pancreatic cancer remains unclear. In this study, we found that NUF2 expression was stronger ...

journal_title：Bioscience reports

authors： Hu P,Chen X,Sun J,Bie P,Zhang LD

更新日期：2015-01-14 00:00:00

abstract：:Purpose: Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain. The purpose of the present study was to evaluate the relationship between the damaged white matter and the impaired cognitive function in WD patients. Materials and methods: Thirty WD adolescen...

journal_title：Bioscience reports

authors： Dong T,Yang WM,Wu MC,Zhang J,Huang P,Xu CS,Wang AQ,Kuang CJ,Gao ZL

更新日期：2019-03-15 00:00:00

abstract：:Acute primary angle-closure (APAC) eyes show an early 'acute inflammatory' condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study invol...

journal_title：Bioscience reports

authors： Wang Y,Chen S,Liu Y,Huang W,Li X,Zhang X

更新日期：2018-12-07 00:00:00

abstract：AIM:IgA nephropathy (IgAN) is one of the most common chronic glomerulonephritis. Its etiology and pathogenesis remain unclear. We thus explored the immune repertoire of the B-cell receptor (BCR) and the heavy-chain complementarity-determining region 3 (CDR3) in renal tissue and peripheral blood of IgAN patients. METHO...

journal_title：Bioscience reports

authors： Chen D,Zhang Z,Yang Y,Hong Q,Li W,Zhuo L

更新日期：2019-10-30 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of hereditary, degenerative retinal disorders characterized by progressive retinal dysfunction, outer retina cell loss, and retinal tissue atrophy. It eventually leads to tunnel vision and legal, or total blindness. Here we aimed to reveal the causal gene and mutation contributing ...

journal_title：Bioscience reports

authors： Huang X,Yuan L,Xu H,Zheng W,Cao Y,Yi J,Guo Y,Yang Z,Li Y,Deng H

更新日期：2018-04-27 00:00:00

abstract：:The solvation properties of ubiquinone-10 and ubiquinol-10 in a wide variety of solvents of polarity varying from alkanes to water are reported. Greatest solubility is observed in solvents of intermediate polarity and particularly where low polarity is combined with a pronounced tendency to interact with the benzoquin...

journal_title：Bioscience reports

authors： Ondarroa M,Sharma SK,Quinn PJ

更新日期：1986-09-01 00:00:00

abstract：:Using both immunohistological study and photoaffinity labelling with radioactive azido-ATP, evidence is presented that the mitochondrial membranes of the brown adipose tissue of the human adult contain a 32 000-Mr uncoupling protein, which is probably similar to the uncoupling protein of BAT of rodents. ...

journal_title：Bioscience reports

authors： Bouillaud F,Combes-George M,Ricquier D

更新日期：1983-08-01 00:00:00

abstract：:To investigate whether the human anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibody-induced membranous nephropathy (MN) is mediated by activating lectin complement pathway. Automatic biochemical apparatus was used to assess renal function of mice. The serum levels of anti-THSD7A antibodies and complemen...

journal_title：Bioscience reports

authors： Wang Z,Wen L,Dou Y,Zhao Z

更新日期：2018-06-21 00:00:00

abstract：:Conflicting opinions were recently expressed concerning the possible effect of alpha 2-adrenergic agonists upon cyclic AMP production in pancreatic islets. In the present study, clonidine inhibited glucose-induced insulin release from rat pancreatic islets, this inhibitory effect being abolished by idazoxan. Clonidine...

journal_title：Bioscience reports

authors： Garcia-Morales P,Dufrane SP,Sener A,Valverde I,Malaisse WJ

更新日期：1984-06-01 00:00:00

abstract：:Diabetes mellitus (DM) is a potential etiology of disc degeneration. Glucagon-like peptide-1 (GLP-1) is currently regarded as a powerful treatment option for type 2 diabetes. Apart from the beneficial effects on glycaemic control, GLP-1 has been reported to exert functions in a variety of tissues on modulation of cell...

journal_title：Bioscience reports

authors： Ming-Yan Y,Jing Z,Shu-Qin G,Xiao-Liang B,Zhi-Hong L,Xue Z

更新日期：2019-08-19 00:00:00

abstract：:Chitinases catalyze the degradation of chitin, a ubiquitous polymer generated from the cell walls of fungi, shells of crustaceans, and cuticles of insects. They are gaining increasing attention in medicine, agriculture, food and drug industries, and environmental management. Their roles in the degradation of chitin fo...

journal_title：Bioscience reports

authors： Oyeleye A,Normi YM

更新日期：2018-08-29 00:00:00

abstract：:This review covers the recent progress in the elucidation of the structure of photosystem II (PSII). Because much of the structural information for this membrane protein complex has been revealed by electron microscopy (EM), the review will also consider the specific technical and interpretation problems that arise wi...

journal_title：Bioscience reports

authors： Nicholson WV,Ford RC,Holzenburg A

更新日期：1996-04-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...

journal_title：Bioscience reports

authors： Mao Z,Li H,Du B,Cui K,Xing Y,Zhao X,Zai S

更新日期：2017-11-06 00:00:00

abstract：:Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...

journal_title：Bioscience reports

authors： Wu J,Pan W,Wang C,Dong H,Xing L,Hou J,Fang S,Li H,Yang F,Yu B

更新日期：2019-07-08 00:00:00

abstract：:Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will l...

journal_title：Bioscience reports

authors： Wang H,Wei HW,Shen HC,Li ZZ,Cheng Y,Duan LS,Yin L,Yu J,Guo JR

更新日期：2020-06-26 00:00:00