Abstract:
:Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A. With CER (cation-exchange resin) and HPLC, we obtained three active components extracted from Terminaliachebula Retz, and named them TCR1, TCR2 and TCR3 respectively. These three components were evaluated with the biosensor, and it was found that the TCR3 was the most capable candidate to bind lipid A. We also studied the biological activities of TCR3 against sepsis in vitro and in vivo. in vitro, TCR3 could significantly inhibit LPS (lipopolysaccharide)-induced LAL (Limulus amoebocyte lysate)) from agglutination and decrease TNFalpha (tumour necrosis factor alpha) release from RAW264.7 cells induced by LPS in a dose-dependent manner. in vivo, TCR3 could significantly protect mice against a lethal challenge with LPS and heat-killed Escherichia coli 35218 in a dose-dependent manner. These results demonstrate that Terminaliachebula Retz is an important herb to neutralize LPS and it has the potential to serve as a treatment for sepsis.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Yao J,Zheng JS,Fu W,Zheng Jdoi
10.1042/BSR20080158subject
Has Abstractpub_date
2009-10-06 00:00:00pages
27-32issue
1eissn
0144-8463issn
1573-4935pii
BSR20080158journal_volume
30pub_type
杂志文章abstract::Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...
journal_title:Bioscience reports
pub_type: 杂志文章,收录出版
doi:10.1042/BSR20171070
更新日期:2017-11-06 00:00:00
abstract:: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182023
更新日期:2019-02-27 00:00:00
abstract::Immobilization of yeast mitochondrial RNA on nitrocellulose filters without prior alkali treatment revealed a low-MW RNA species (integral of 300 bases) which hybridizes specifically to the RNA coding strand of a DNA fragment BglII-HinfI at the 3' end of the COB-BOX gene. This RNA species (often a doublet) was found i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116301
更新日期:1981-07-01 00:00:00
abstract::The family of 5-HT4 receptors comprises 16 putative splice variants. We have previously shown that there are differences in signal transduction of the h5-HT(4a) and h5-HT(4b) receptors. In the present study, the internalization of these two splice variants following receptor stimulation was investigated with confocal ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/s10540-005-2582-5
更新日期:2004-06-01 00:00:00
abstract::eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2-3 phosphates per eNOS monomer. Phosphorylation decreases NO synthesis...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140015
更新日期:2014-09-17 00:00:00
abstract::Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific end...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201471
更新日期:2020-10-30 00:00:00
abstract::The identification of the sodium potassium pump as a Na+, K+ -ATPase is described. ...
journal_title:Bioscience reports
pub_type: 传,历史文章
doi:10.1023/a:1020196612909
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. MATERIALS AND METHODS:The data used in this research were collected from Google Scholar, Web of Science, CNKI, and ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193877
更新日期:2021-01-27 00:00:00
abstract::In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115230
更新日期:1988-08-01 00:00:00
abstract::Peptide sequencing of the complement system regulatory protein, factor H, permitted the synthesis of a mixed sequence oligonucleotide probe. Human liver cDNA libraries were screened and factor H-specific clones selected. No full-length clone was obtained, but the largest available clone, R2a, was found to encode the C...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01124790
更新日期:1987-03-01 00:00:00
abstract::CXCL8, a member of CXC chemokines, was constitutively expressed in many types of human cancers, and its overexpression has been shown to play a critical role in promoting tumorigenesis. The purpose of the present study was to determine CXCL8 expression in a commercial human liver tissue microarray, and elucidate the e...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201169
更新日期:2020-08-28 00:00:00
abstract::The effect of carbamylcholine and the calcium ionophore A23187 on catecholamine release and intracellular free calcium, [Ca2+]i, in bovine adrenal chromaffin cells was determined. At 10(-4) M carbamylcholine maximal release occurred with an accompanying increase in [Ca2+]i from a basal level of 168 nM to less than 300...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121918
更新日期:1984-07-01 00:00:00
abstract::Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190100
更新日期:2019-05-02 00:00:00
abstract::Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we assessed mitochondri...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20140151
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Glioma is the most common malignant tumor in the human central nervous system. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) promotes oncogenesis in various tumors. In the present study, we aimed to examine the role of NEAT1 in altering the properties of gliomas. METHODS:Quantitative ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200767
更新日期:2021-01-04 00:00:00
abstract::miRNAs are non-coding RNA molecules typically 18-22 nucleotides long that can suppress the expression of their target genes. Several laboratories have attempted to identify miRNAs from the pig that are involved in Salmonella infection. These bioinformatics strategies using the newly available genomic sequence are gene...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20160243
更新日期:2016-08-31 00:00:00
abstract::Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorec...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180243
更新日期:2018-12-07 00:00:00
abstract::Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
更新日期:2019-02-19 00:00:00
abstract::Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled polypeptide. Secretion of the non-glycosylated protein ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119592
更新日期:1985-03-01 00:00:00
abstract::In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201084
更新日期:2020-09-30 00:00:00
abstract::We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
更新日期:1996-02-01 00:00:00
abstract::Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116998
更新日期:1985-08-01 00:00:00
abstract::Background: As one of the most common liver disorders worldwide, non-alcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver. Long non-coding RNA-H19 was reported to modulate hepatic metabolic homeostasis in NAFLD. However, its molecular mechanism of NAFLD was not ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181722
更新日期:2019-07-15 00:00:00
abstract::Endothelin-1 (ET-1) and plasminogen activator inhibitor-1 (PAI-1) play important roles in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show higher levels of placenta growth factor (PlGF) in SCD correlate with increased plasma levels of ET-1, PAI-1, and other physiological markers of P...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150190
更新日期:2015-10-12 00:00:00
abstract::Non-Small Cell Lung Cancer (NSCLC) is responsible for the majority of deaths caused by cancer. Small C-terminal domain (CTD) phosphatases (SCP), CTDSP1, CTDSP2 and CTDSPL (CTDSPs) belong to SCP/CTDSP subfamily and are involved in many vital cellular processes and tumorigenesis. High similarity of their structures sugg...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20193094
更新日期:2019-12-20 00:00:00
abstract::The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190091
更新日期:2019-04-16 00:00:00
abstract::Glycine methyl ester, an inhibitor of transglutaminase, decreased glucose-stimulated insulin release and delayed proinsulin conversion in rat pancreatic islets pulse-labelled with L-[4-3H]phenylalanine. Sarcosine methyl ester, which does not inhibit transglutaminase activity, failed to affect insulin release and proin...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117071
更新日期:1985-07-01 00:00:00
abstract::Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116851
更新日期:1990-02-01 00:00:00
abstract::Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190304
更新日期:2019-07-08 00:00:00
abstract::Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181228
更新日期:2018-12-14 00:00:00